Corticosteroid resistance in sepsis is influenced by microRNA-124-induced downregulation of glucocorticoid receptor-α*
Acquired glucocorticoid resistance frequently complicates the therapy of sepsis. It leads to an exaggerated proinflammatory response and has been related to altered expression profiles of glucocorticoid receptor isoforms glucocorticoid receptor-α (mediating anti-inflammatory effects) and glucocortic...
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2012/10/01
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| In: |
Critical care medicine
Year: 2012, Jahrgang: 40, Heft: 10, Pages: 2745-2753 |
| ISSN: | 1530-0293 |
| DOI: | 10.1097/CCM.0b013e31825b8ebc |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1097/CCM.0b013e31825b8ebc Verlag, Volltext: https://journals.lww.com/ccmjournal/Abstract/2012/10000/Corticosteroid_resistance_in_sepsis_is_influenced.1.aspx 
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| Verfasserangaben: | Carola Ledderose, Patrick Möhnle, Elisabeth Limbeck, Stefanie Schütz, Florian Weis, Jessica Rink, Josef Briegel, Simone Kreth |
| Zusammenfassung: | Acquired glucocorticoid resistance frequently complicates the therapy of sepsis. It leads to an exaggerated proinflammatory response and has been related to altered expression profiles of glucocorticoid receptor isoforms glucocorticoid receptor-α (mediating anti-inflammatory effects) and glucocorticoid receptor-β (acting as a dominant negative inhibitor). We investigated the impact of glucocorticoid receptor isoforms on glucocorticoid effects in human T-cells. We hypothesized that 1) changes of the ratio of glucocorticoid receptor isoforms impact glucocorticoid resistance and 2) glucocorticoid receptor-α expression is controlled by microRNA-mediated gene silencing. |
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| Beschreibung: | Gesehen am 04.06.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1530-0293 |
| DOI: | 10.1097/CCM.0b013e31825b8ebc |