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Evidence for the subsynaptic zone as a preferential site for CHRN recycling at neuromuscular junctions

Vertebrate skeletal muscle contraction is mediated by nicotinic acetylcholine receptors (CHRN). Endocytosis and recycling of CHRN regulate their proper abundance at nerve-muscle synapses, i.e. neuromuscular junctions. Recent work showed that RAB5 is essential for CHRN endocytosis. Here, using in viv...

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Hauptverfasser: Wild, Franziska (VerfasserIn) , Khan, Muzamil Majid (VerfasserIn) , Rudolf, Rüdiger (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2019
In: Small GTPases
Year: 2017, Jahrgang: 10, Heft: 5, Pages: 1-8
ISSN:2154-1256
DOI:10.1080/21541248.2017.1324939
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1080/21541248.2017.1324939
Verlag, Volltext: https://doi.org/10.1080/21541248.2017.1324939
Volltext
Verfasserangaben:Franziska Wild, Muzamil Majid Khan, Rüdiger Rudolf

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520 |a Vertebrate skeletal muscle contraction is mediated by nicotinic acetylcholine receptors (CHRN). Endocytosis and recycling of CHRN regulate their proper abundance at nerve-muscle synapses, i.e. neuromuscular junctions. Recent work showed that RAB5 is essential for CHRN endocytosis. Here, using in vivo-imaging of endocytosed CHRN and RAB-GFP fusion proteins, we deliver evidence for differential effects of RAB5-GFP, RAB4-GFP, and RAB11-GFP on CHRN endocytosis. Furthermore, while newly endocytosed CHRN colocalized with RAB5-GFP over large stretches of muscle fibers, RAB4-GFP and RAB11-GFP colocalized with endocytosed CHRN almost exclusively at neuromuscular junctions. In agreement with previous findings, this data suggests the existence of a specialized subsynaptic zone that is particularly relevant for CHRN recycling. 
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