FOXM1 predicts overall and disease specific survival in muscle-invasive urothelial carcinoma and presents a differential expression between bladder cancer subtypes
Forkhead box M1 (FOXM1) is a late cell cycle gene that plays a crucial role in carcinogenesis and chemotherapeutic drug resistance. In this study, the impact of FOXM1 expression on patient outcome was investigated for the first time in formalin fixed and paraffin embedded (FFPE) samples of chemother...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
April 24, 2017
|
| In: |
OncoTarget
Year: 2017, Jahrgang: 8, Heft: 29, Pages: 47595-47606 |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.17394 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.18632/oncotarget.17394 Verlag, kostenfrei, Volltext: http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=17394&path[]=55649 
|
| Verfasserangaben: | Sebastien Rinaldetti, Ralph Markus Wirtz, Thomas Stefan Worst, Markus Eckstein, Cleo Aaron Weiss, Johannes Breyer, Wolfgang Otto, Christian Bolenz, Arndt Hartmann and Philipp Erben |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1576116883 | ||
| 003 | DE-627 | ||
| 005 | 20230427042926.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180606s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.18632/oncotarget.17394 |2 doi | |
| 035 | |a (DE-627)1576116883 | ||
| 035 | |a (DE-576)506116883 | ||
| 035 | |a (DE-599)BSZ506116883 | ||
| 035 | |a (OCoLC)1341011082 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Rinaldetti, Sébastien |d 1988- |e VerfasserIn |0 (DE-588)1073669157 |0 (DE-627)829329730 |0 (DE-576)435254952 |4 aut | |
| 245 | 1 | 0 | |a FOXM1 predicts overall and disease specific survival in muscle-invasive urothelial carcinoma and presents a differential expression between bladder cancer subtypes |c Sebastien Rinaldetti, Ralph Markus Wirtz, Thomas Stefan Worst, Markus Eckstein, Cleo Aaron Weiss, Johannes Breyer, Wolfgang Otto, Christian Bolenz, Arndt Hartmann and Philipp Erben |
| 264 | 1 | |c April 24, 2017 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 06.06.2018 | ||
| 520 | |a Forkhead box M1 (FOXM1) is a late cell cycle gene that plays a crucial role in carcinogenesis and chemotherapeutic drug resistance. In this study, the impact of FOXM1 expression on patient outcome was investigated for the first time in formalin fixed and paraffin embedded (FFPE) samples of chemotherapy naïve muscle-invasive bladder cancer (MIBC) patients. Expression analyses were performed on the Mannheim cohort (n=84) and validated on the independent Chungbuk cohort (n=61). In a Cox’ proportional hazards model, a distinct FOXM1 expression cut-off dividing both cohorts in a ‘high-risk’ and ‘low-risk’ group has been determined. Multivariate analyses showed that FOXM1 is an independent risk factor for outcome prediction superior to the TNM system. The FOXM1 ‘high-risk’ group had a 4- to 7-fold increased risk of death (p<0.03) and presented further an overexpression of MKI67. Recent studies showed that MIBCs can be subclassified in breast cancer-like subtypes: basal, luminal and p53-like. Here we demonstrated that FOXM1 was differentially expressed between MIBC subtypes concordant to its subtype specific expression in breast cancer. Since the proto-oncogene FOXM1 is known to play an important role in cisplatin resistance and to be a promising drug target, this study supports FOXM1 as a crucial biomarker in the personalization of MIBC therapy and urges prospective translational studies. | ||
| 700 | 1 | |a Worst, Thomas |d 1985- |e VerfasserIn |0 (DE-588)1028335679 |0 (DE-627)73058500X |0 (DE-576)375827501 |4 aut | |
| 700 | 1 | |a Weis, Cleo-Aron Thias |d 1985- |e VerfasserIn |0 (DE-588)1062803752 |0 (DE-627)806961198 |0 (DE-576)42022730X |4 aut | |
| 700 | 1 | |a Erben, Philipp |d 1973- |e VerfasserIn |0 (DE-588)128501014 |0 (DE-627)373920997 |0 (DE-576)297181661 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t OncoTarget |d [Erscheinungsort nicht ermittelbar] : Impact Journals LLC, 2010 |g 8(2017), 29, Seite 47595-47606 |h Online-Ressource |w (DE-627)63035975X |w (DE-600)2560162-3 |w (DE-576)325343764 |x 1949-2553 |7 nnas |a FOXM1 predicts overall and disease specific survival in muscle-invasive urothelial carcinoma and presents a differential expression between bladder cancer subtypes |
| 773 | 1 | 8 | |g volume:8 |g year:2017 |g number:29 |g pages:47595-47606 |g extent:12 |a FOXM1 predicts overall and disease specific survival in muscle-invasive urothelial carcinoma and presents a differential expression between bladder cancer subtypes |
| 856 | 4 | 0 | |u http://dx.doi.org/10.18632/oncotarget.17394 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=17394&path[]=55649 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180606 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 128501014 |a Erben, Philipp |m 128501014:Erben, Philipp |d 60000 |d 63100 |e 60000PE128501014 |e 63100PE128501014 |k 0/60000/ |k 1/60000/63100/ |p 10 |y j | ||
| 998 | |g 1062803752 |a Weis, Cleo-Aron Thias |m 1062803752:Weis, Cleo-Aron Thias |d 60000 |d 63400 |e 60000PW1062803752 |e 63400PW1062803752 |k 0/60000/ |k 1/60000/63400/ |p 5 | ||
| 998 | |g 1028335679 |a Worst, Thomas |m 1028335679:Worst, Thomas |d 60000 |d 63100 |e 60000PW1028335679 |e 63100PW1028335679 |k 0/60000/ |k 1/60000/63100/ |p 3 | ||
| 998 | |g 1073669157 |a Rinaldetti, Sébastien |m 1073669157:Rinaldetti, Sébastien |d 60000 |d 61200 |e 60000PR1073669157 |e 61200PR1073669157 |k 0/60000/ |k 1/60000/61200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1576116883 |e 3011788219 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Sebastien Rinaldetti, Ralph Markus Wirtz, Thomas Stefan Worst, Markus Eckstein, Cleo Aaron Weiss, Johannes Breyer, Wolfgang Otto, Christian Bolenz, Arndt Hartmann and Philipp Erben"]},"physDesc":[{"extent":"12 S."}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 06.06.2018"],"origin":[{"dateIssuedDisp":"April 24, 2017","dateIssuedKey":"2017"}],"title":[{"title":"FOXM1 predicts overall and disease specific survival in muscle-invasive urothelial carcinoma and presents a differential expression between bladder cancer subtypes","title_sort":"FOXM1 predicts overall and disease specific survival in muscle-invasive urothelial carcinoma and presents a differential expression between bladder cancer subtypes"}],"recId":"1576116883","language":["eng"],"id":{"doi":["10.18632/oncotarget.17394"],"eki":["1576116883"]},"relHost":[{"id":{"eki":["63035975X"],"zdb":["2560162-3"],"issn":["1949-2553"]},"recId":"63035975X","language":["eng"],"title":[{"title_sort":"OncoTarget","title":"OncoTarget","subtitle":"open access impact journal"}],"pubHistory":["1.2010,Mai -"],"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 16.08.2018"],"origin":[{"dateIssuedDisp":"2010-","dateIssuedKey":"2010","publisher":"Impact Journals LLC","publisherPlace":"[Erscheinungsort nicht ermittelbar]"}],"part":{"volume":"8","text":"8(2017), 29, Seite 47595-47606","year":"2017","pages":"47595-47606","issue":"29","extent":"12"},"physDesc":[{"extent":"Online-Ressource"}],"disp":"FOXM1 predicts overall and disease specific survival in muscle-invasive urothelial carcinoma and presents a differential expression between bladder cancer subtypesOncoTarget"}],"person":[{"family":"Rinaldetti","given":"Sébastien","roleDisplay":"VerfasserIn","role":"aut","display":"Rinaldetti, Sébastien"},{"display":"Worst, Thomas","family":"Worst","given":"Thomas","role":"aut","roleDisplay":"VerfasserIn"},{"display":"Weis, Cleo-Aron Thias","family":"Weis","given":"Cleo-Aron Thias","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Erben, Philipp","role":"aut","roleDisplay":"VerfasserIn","given":"Philipp","family":"Erben"}]} | ||
| SRT | |a RINALDETTIFOXM1PREDI2420 | ||