Buchumschlag

Active Wnt proteins are secreted on exosomes

Wnt signalling has important roles during development and in many diseases. As morphogens, hydrophobic Wnt proteins exert their function over a distance to induce patterning and cell differentiation decisions. Recent studies have identified several factors that are required for the secretion of Wnt...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Groß, Julia Christina (VerfasserIn) , Chaudhary, Varun (VerfasserIn) , Bartscherer, Kerstin (VerfasserIn) , Boutros, Michael (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2012
In: Nature cell biology
Year: 2012, Jahrgang: 14, Heft: 10, Pages: 1036-1045
ISSN:1476-4679
DOI:10.1038/ncb2574
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1038/ncb2574
Verlag, Volltext: https://www.nature.com/articles/ncb2574
Volltext
Verfasserangaben:Julia Christina Gross, Varun Chaudhary, Kerstin Bartscherer, and Michael Boutros

MARC

LEADER 00000caa a2200000 c 4500
001 1576139700
003 DE-627
005 20220814154927.0
007 cr uuu---uuuuu
008 180607s2012 xx |||||o 00| ||eng c
024 7 |a 10.1038/ncb2574  |2 doi 
035 |a (DE-627)1576139700 
035 |a (DE-576)506139700 
035 |a (DE-599)BSZ506139700 
035 |a (OCoLC)1341011207 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 30  |2 sdnb 
100 1 |a Groß, Julia Christina  |d 1980-  |e VerfasserIn  |0 (DE-588)139632840  |0 (DE-627)703407155  |0 (DE-576)31252224X  |4 aut 
245 1 0 |a Active Wnt proteins are secreted on exosomes  |c Julia Christina Gross, Varun Chaudhary, Kerstin Bartscherer, and Michael Boutros 
264 1 |c 2012 
300 |a 10 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Published online 16 September 2012 
500 |a Gesehen am 07.06.2018 
520 |a Wnt signalling has important roles during development and in many diseases. As morphogens, hydrophobic Wnt proteins exert their function over a distance to induce patterning and cell differentiation decisions. Recent studies have identified several factors that are required for the secretion of Wnt proteins; however, how Wnts travel in the extracellular space remains a largely unresolved question. Here we show that Wnts are secreted on exosomes both during Drosophila development and in human cells. We demonstrate that exosomes carry Wnts on their surface to induce Wnt signalling activity in target cells. Together with the cargo receptor Evi/WIs, Wnts are transported through endosomal compartments onto exosomes, a process that requires the R-SNARE Ykt6. Our study demonstrates an evolutionarily conserved functional role of extracellular vesicular transport of Wnt proteins. 
700 1 |a Chaudhary, Varun  |e VerfasserIn  |0 (DE-588)1161677356  |0 (DE-627)1025142519  |0 (DE-576)506800784  |4 aut 
700 1 |a Bartscherer, Kerstin  |e VerfasserIn  |0 (DE-588)135715040  |0 (DE-627)570562104  |0 (DE-576)300604157  |4 aut 
700 1 |a Boutros, Michael  |e VerfasserIn  |0 (DE-588)1023031132  |0 (DE-627)717350045  |0 (DE-576)366291831  |4 aut 
773 0 8 |i Enthalten in  |t Nature cell biology  |d New York, NY : Nature America, 1999  |g 14(2012), 10, Seite 1036-1045  |h Online-Ressource  |w (DE-627)303393726  |w (DE-600)1494945-3  |w (DE-576)08088718X  |x 1476-4679  |7 nnas  |a Active Wnt proteins are secreted on exosomes 
773 1 8 |g volume:14  |g year:2012  |g number:10  |g pages:1036-1045  |g extent:10  |a Active Wnt proteins are secreted on exosomes 
856 4 0 |u http://dx.doi.org/10.1038/ncb2574  |x Verlag  |x Resolving-System  |3 Volltext 
856 4 0 |u https://www.nature.com/articles/ncb2574  |x Verlag  |3 Volltext 
951 |a AR 
992 |a 20180607 
993 |a Article 
994 |a 2012 
998 |g 1023031132  |a Boutros, Michael  |m 1023031132:Boutros, Michael  |d 60000  |e 60000PB1023031132  |k 0/60000/  |p 4  |y j 
998 |g 135715040  |a Bartscherer, Kerstin  |m 135715040:Bartscherer, Kerstin  |p 3 
998 |g 1161677356  |a Chaudhary, Varun  |m 1161677356:Chaudhary, Varun  |d 60000  |d 999810  |e 60000PC1161677356  |e 999810PC1161677356  |k 0/60000/  |k 1/60000/999810/  |p 2 
998 |g 139632840  |a Groß, Julia Christina  |m 139632840:Groß, Julia Christina  |d 60000  |d 999810  |e 60000PG139632840  |e 999810PG139632840  |k 0/60000/  |k 1/60000/999810/  |p 1  |x j 
999 |a KXP-PPN1576139700  |e 3012045937 
BIB |a Y 
SER |a journal 
JSO |a {"origin":[{"dateIssuedDisp":"2012","dateIssuedKey":"2012"}],"person":[{"family":"Groß","given":"Julia Christina","role":"aut","display":"Groß, Julia Christina"},{"role":"aut","given":"Varun","family":"Chaudhary","display":"Chaudhary, Varun"},{"role":"aut","given":"Kerstin","family":"Bartscherer","display":"Bartscherer, Kerstin"},{"display":"Boutros, Michael","family":"Boutros","role":"aut","given":"Michael"}],"relHost":[{"origin":[{"dateIssuedDisp":"1999-","dateIssuedKey":"1999","publisherPlace":"New York, NY","publisher":"Nature America"}],"title":[{"title":"Nature cell biology","title_sort":"Nature cell biology"}],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 02.03.05"],"recId":"303393726","physDesc":[{"extent":"Online-Ressource"}],"disp":"Active Wnt proteins are secreted on exosomesNature cell biology","pubHistory":["1.1999 -"],"titleAlt":[{"title":"Cell biology"}],"id":{"zdb":["1494945-3"],"issn":["1476-4679"],"eki":["303393726"]},"part":{"extent":"10","text":"14(2012), 10, Seite 1036-1045","issue":"10","pages":"1036-1045","volume":"14","year":"2012"}}],"title":[{"title_sort":"Active Wnt proteins are secreted on exosomes","title":"Active Wnt proteins are secreted on exosomes"}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Published online 16 September 2012","Gesehen am 07.06.2018"],"recId":"1576139700","physDesc":[{"extent":"10 S."}],"name":{"displayForm":["Julia Christina Gross, Varun Chaudhary, Kerstin Bartscherer, and Michael Boutros"]},"id":{"eki":["1576139700"],"doi":["10.1038/ncb2574"]}} 
SRT |a GROSSJULIAACTIVEWNTP2012 

Ähnliche Einträge