Improved detection of alcohol consumption using the novel marker phosphatidylethanol in the transplant setting: results of a prospective study
Phosphatidylethanol (PEth) is a new, highly specific alcohol marker. The aim of this study was to assess its diagnostic value in the liver transplant setting. In 51 pre- and 61 post-transplant patients with underlying alcoholic liver disease PEth, ethanol, methanol, carbohydrate-deficient transferri...
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| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2017
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| In: |
Transplant international
Year: 2017, Volume: 30, Issue: 6, Pages: 611-620 |
| ISSN: | 1432-2277 |
| DOI: | 10.1111/tri.12949 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1111/tri.12949
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| Author Notes: | Hilke Andresen-Streichert, Yannick Beres, Wolfgang Weinmann, Alexandra Schröck, Alexander Müller, Gisela Skopp, Sven Pischke, Eik Vettorazzi, Ansgar Lohse, Björn Nashan & Martina Sterneck |
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| 245 | 1 | 0 | |a Improved detection of alcohol consumption using the novel marker phosphatidylethanol in the transplant setting |b results of a prospective study |c Hilke Andresen-Streichert, Yannick Beres, Wolfgang Weinmann, Alexandra Schröck, Alexander Müller, Gisela Skopp, Sven Pischke, Eik Vettorazzi, Ansgar Lohse, Björn Nashan & Martina Sterneck |
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| 520 | |a Phosphatidylethanol (PEth) is a new, highly specific alcohol marker. The aim of this study was to assess its diagnostic value in the liver transplant setting. In 51 pre- and 61 post-transplant patients with underlying alcoholic liver disease PEth, ethanol, methanol, carbohydrate-deficient transferrin (CDT), and ethyl glucuronide in urine (uEtG) and hair (hEtG) were tested and compared with patients' questionnaire reports. Twenty-eight (25%) patients tested positive for at least one alcohol marker. PEth alone revealed alcohol consumption in 18% of patients. With respect to detection of alcohol intake in the preceding week, PEth showed a 100% sensitivity. PEth testing was more sensitive than the determination of ethanol, methanol, CDT or uEtG alone [sensitivity 25% (confidence interval (CI) 95%, 7-52%), 25% (7-52%), 21% (6-45%) and 71% (41-91%), respectively], or ethanol, methanol and uEtG taken in combination with 73% (45-92%). Specificity of all markers was 92% or higher. Additional testing of hEtG revealed alcohol consumption in seven patients, not being positive for any other marker. Phosphatidylethanol was a highly specific and sensitive marker for detection of recent alcohol consumption in pre- and post-transplant patients. The additional determination of hEtG was useful in disclosing alcohol consumption 3-6 months retrospectively. | ||
| 650 | 4 | |a Alcohol Drinking | |
| 650 | 4 | |a alcoholic liver disease | |
| 650 | 4 | |a Biomarkers | |
| 650 | 4 | |a carbohydrate-deficient transferrin | |
| 650 | 4 | |a cirrhosis | |
| 650 | 4 | |a Ethanol | |
| 650 | 4 | |a ethyl glucuronide | |
| 650 | 4 | |a False Positive Reactions | |
| 650 | 4 | |a Glucuronates | |
| 650 | 4 | |a Glycerophospholipids | |
| 650 | 4 | |a Hair | |
| 650 | 4 | |a Liver Diseases, Alcoholic | |
| 650 | 4 | |a Liver Transplantation | |
| 650 | 4 | |a Methanol | |
| 650 | 4 | |a phosphatidylethanol | |
| 650 | 4 | |a Prospective Studies | |
| 650 | 4 | |a Retrospective Studies | |
| 650 | 4 | |a Sensitivity and Specificity | |
| 650 | 4 | |a Surveys and Questionnaires | |
| 650 | 4 | |a Transferrin | |
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