High evening cortisol level is associated with low TBS and increased prevalent vertebral fractures: OsteoLaus study
Context: Increased evening cortisol levels have been implicated in bone mineral density (BMD) loss. The effect on bone microarchitecture and fracture risk has never been studied. Objective: To study the relationship between salivary cortisol circadian rhythm and (1) trabecular bone score (TBS) and (...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
1 July 2017
|
| In: |
The journal of clinical endocrinology & metabolism
Year: 2017, Volume: 102, Issue: 7, Pages: 2628-2636 |
| ISSN: | 1945-7197 |
| DOI: | 10.1210/jc.2016-3804 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1210/jc.2016-3804 Verlag, kostenfrei, Volltext: https://academic-oup-com.ezproxy.medma.uni-heidelberg.de/jcem/article/102/7/2628/3100442 
|
| Author Notes: | Elena Gonzalez Rodriguez, Olivier Lamy, Delphine Stoll, Marie Metzger, Martin Preisig, Christine Kuehner, Peter Vollenweider, Pedro Marques-Vidal, Gérard Waeber, Bérengère Aubry-Rozier, and Didier Hans |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1576272516 | ||
| 003 | DE-627 | ||
| 005 | 20220814161140.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180612s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1210/jc.2016-3804 |2 doi | |
| 035 | |a (DE-627)1576272516 | ||
| 035 | |a (DE-576)506272516 | ||
| 035 | |a (DE-599)BSZ506272516 | ||
| 035 | |a (OCoLC)1341011500 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Gonzalez Rodriguez, Elena |e VerfasserIn |0 (DE-588)1160950873 |0 (DE-627)1024335402 |0 (DE-576)50627232X |4 aut | |
| 245 | 1 | 0 | |a High evening cortisol level is associated with low TBS and increased prevalent vertebral fractures |b OsteoLaus study |c Elena Gonzalez Rodriguez, Olivier Lamy, Delphine Stoll, Marie Metzger, Martin Preisig, Christine Kuehner, Peter Vollenweider, Pedro Marques-Vidal, Gérard Waeber, Bérengère Aubry-Rozier, and Didier Hans |
| 264 | 1 | |c 1 July 2017 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a First published online 4 April 2017 | ||
| 500 | |a Gesehen am 12.06.2018 | ||
| 520 | |a Context: Increased evening cortisol levels have been implicated in bone mineral density (BMD) loss. The effect on bone microarchitecture and fracture risk has never been studied. Objective: To study the relationship between salivary cortisol circadian rhythm and (1) trabecular bone score (TBS) and (2) fracture prevalence. Design, Setting, Patients, and Interventions: Cross-sectional study including 608 women >50 years old (mean = 65.5) from the OsteoLaus cohort. Data included the FRAX© questionnaire, BMD, TBS and vertebral fracture (VFx) assessment by dual X-ray absorptiometry, and measures of salivary cortisol (awakening, 30 minutes thereafter, 11 am, and 8 pm). Results: In the multivariate model, participants in the highest tertile of 8 pm salivary cortisol (sc-8 pm) (mean = 5.7 ± 2.5 nmol/L) vs lowest tertile (1.7 ± 0.4 nmol/L) had lower TBS values (1.27 vs 1.29; P = 0.02), more prevalent VFx grades 2 and 3 (odds ratio = 5.34; P = 0.012), low-trauma fractures (odds ratio = 1.80; P = 0.036), and major osteoporotic fractures (odds ratio = 1.96; P = 0.042), without difference in lumbar spine BMD (0.91 vs 0.92 g/cm2; P = 0.431). VFx prevalence was associated with sc-8 pm and TBS independently of each other and of other risk factors. The cut-point for sc-8 pm correlating with the presence of >1 VFx was 3.62 nmol/L (sensitivity 0.74, specificity 0.66). Conclusions: High sc-8 pm is associated with low TBS and an increased prevalence of radiologic VFx independently of other risk factors. Measurement of sc-8 pm may add relevant information in the assessment of fracture risk. | ||
| 700 | 1 | |a Kühner, Christine |d 1957- |e VerfasserIn |0 (DE-588)118141120 |0 (DE-627)079267777 |0 (DE-576)291736238 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of clinical endocrinology & metabolism |d Oxford : Oxford University Press, 1941 |g 102(2017), 7, Seite 2628-2636 |h Online-Ressource |w (DE-627)323606261 |w (DE-600)2026217-6 |w (DE-576)094425523 |x 1945-7197 |7 nnas |a High evening cortisol level is associated with low TBS and increased prevalent vertebral fractures OsteoLaus study |
| 773 | 1 | 8 | |g volume:102 |g year:2017 |g number:7 |g pages:2628-2636 |g extent:9 |a High evening cortisol level is associated with low TBS and increased prevalent vertebral fractures OsteoLaus study |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1210/jc.2016-3804 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://academic-oup-com.ezproxy.medma.uni-heidelberg.de/jcem/article/102/7/2628/3100442 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180612 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 118141120 |a Kühner, Christine |m 118141120:Kühner, Christine |d 60000 |e 60000PK118141120 |k 0/60000/ |p 6 | ||
| 999 | |a KXP-PPN1576272516 |e 3012507698 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1576272516","id":{"eki":["1576272516"],"doi":["10.1210/jc.2016-3804"]},"note":["First published online 4 April 2017","Gesehen am 12.06.2018"],"physDesc":[{"extent":"9 S."}],"person":[{"roleDisplay":"VerfasserIn","display":"Gonzalez Rodriguez, Elena","role":"aut","family":"Gonzalez Rodriguez","given":"Elena"},{"role":"aut","display":"Kühner, Christine","roleDisplay":"VerfasserIn","given":"Christine","family":"Kühner"}],"name":{"displayForm":["Elena Gonzalez Rodriguez, Olivier Lamy, Delphine Stoll, Marie Metzger, Martin Preisig, Christine Kuehner, Peter Vollenweider, Pedro Marques-Vidal, Gérard Waeber, Bérengère Aubry-Rozier, and Didier Hans"]},"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 30.03.2017"],"pubHistory":["1.1941 -"],"name":{"displayForm":["Endocrine Society"]},"id":{"eki":["323606261"],"zdb":["2026217-6"],"issn":["1945-7197"]},"recId":"323606261","corporate":[{"roleDisplay":"Herausgebendes Organ","role":"isb","display":"Endocrine Society"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"titleAlt":[{"title":"JCEM"},{"title":"The Journal of clinical endocrinology"}],"title":[{"title":"The journal of clinical endocrinology & metabolism","title_sort":"journal of clinical endocrinology & metabolism","subtitle":"JCEM"}],"origin":[{"publisherPlace":"Oxford ; Bethesda, Md.","dateIssuedKey":"1941","dateIssuedDisp":"1941-","publisher":"Oxford University Press ; Endocrine Society"}],"disp":"High evening cortisol level is associated with low TBS and increased prevalent vertebral fractures OsteoLaus studyThe journal of clinical endocrinology & metabolism","part":{"text":"102(2017), 7, Seite 2628-2636","volume":"102","extent":"9","pages":"2628-2636","year":"2017","issue":"7"},"language":["eng"]}],"origin":[{"dateIssuedDisp":"1 July 2017","dateIssuedKey":"2017"}],"title":[{"title":"High evening cortisol level is associated with low TBS and increased prevalent vertebral fractures","title_sort":"High evening cortisol level is associated with low TBS and increased prevalent vertebral fractures","subtitle":"OsteoLaus study"}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"}} | ||
| SRT | |a GONZALEZROHIGHEVENIN1201 | ||