The Drosophila Hox gene ultrabithorax acts in both muscles and motoneurons to orchestrate formation of specific neuromuscular connections
Hox genes are known to specify motoneuron pools in the developing vertebrate spinal cord and to control motoneuronal targeting in several species. However, the mechanisms controlling axial diversification of muscle innervation patterns are still largely unknown. We present data showing that the Dros...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2017
|
| In: |
Development
Year: 2016, Jahrgang: 144, Heft: 1, Pages: 139-150 |
| ISSN: | 1477-9129 |
| DOI: | 10.1242/dev.143875 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1242/dev.143875 Verlag, kostenfrei, Volltext: http://dev.biologists.org/content/144/1/139 
|
| Verfasserangaben: | Christian Hessinger, Gerhard M. Technau and Ana Rogulja-Ortmann |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1576326063 | ||
| 003 | DE-627 | ||
| 005 | 20220814162431.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180613r20172016xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1242/dev.143875 |2 doi | |
| 035 | |a (DE-627)1576326063 | ||
| 035 | |a (DE-576)506326063 | ||
| 035 | |a (DE-599)BSZ506326063 | ||
| 035 | |a (OCoLC)1341011647 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Hessinger, Christian |d 1985- |e VerfasserIn |0 (DE-588)1117829812 |0 (DE-627)871683520 |0 (DE-576)479291675 |4 aut | |
| 245 | 1 | 4 | |a The Drosophila Hox gene ultrabithorax acts in both muscles and motoneurons to orchestrate formation of specific neuromuscular connections |c Christian Hessinger, Gerhard M. Technau and Ana Rogulja-Ortmann |
| 264 | 1 | |c 2017 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published as accepted manuscript 2 December 2016 and published as research article online January 3, 2017 | ||
| 500 | |a Gesehen am 13.06.2018 | ||
| 520 | |a Hox genes are known to specify motoneuron pools in the developing vertebrate spinal cord and to control motoneuronal targeting in several species. However, the mechanisms controlling axial diversification of muscle innervation patterns are still largely unknown. We present data showing that the Drosophila Hox gene Ultrabithorax (Ubx) acts in the late embryo to establish target specificity of ventrally projecting RP motoneurons. In abdominal segments A2 to A7, RP motoneurons innervate the ventrolateral muscles VL1-4, with VL1 and VL2 being innervated in a Wnt4-dependent manner. In Ubx mutants, these motoneurons fail to make correct contacts with muscle VL1, a phenotype partially resembling that of the Wnt4 mutant. We show that Ubx regulates expression of Wnt4 in muscle VL2 and that it interacts with the Wnt4 response pathway in the respective motoneurons. Ubx thus orchestrates the interaction between two cell types, muscles and motoneurons, to regulate establishment of the ventrolateral neuromuscular network. | ||
| 534 | |c 2016 | ||
| 700 | 1 | |a Technau, Gerhard |d 1951- |e VerfasserIn |0 (DE-588)1163969583 |0 (DE-627)1028358342 |0 (DE-576)508290430 |4 aut | |
| 700 | 1 | |a Rogulja-Ortmann, Ana |d 1972- |e VerfasserIn |0 (DE-588)140040994 |0 (DE-627)615244130 |0 (DE-576)314307176 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Development |d Cambridge : The Company of Biologists, 1987 |g 144(2017), 1, Seite 139-150 |h Online-Ressource |w (DE-627)31982439X |w (DE-600)2007916-3 |w (DE-576)090893131 |x 1477-9129 |7 nnas |a The Drosophila Hox gene ultrabithorax acts in both muscles and motoneurons to orchestrate formation of specific neuromuscular connections |
| 773 | 1 | 8 | |g volume:144 |g year:2017 |g number:1 |g pages:139-150 |g extent:12 |a The Drosophila Hox gene ultrabithorax acts in both muscles and motoneurons to orchestrate formation of specific neuromuscular connections |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1242/dev.143875 |x Verlag |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://dev.biologists.org/content/144/1/139 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180613 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 140040994 |a Rogulja-Ortmann, Ana |m 140040994:Rogulja-Ortmann, Ana |d 700000 |d 721000 |e 700000PR140040994 |e 721000PR140040994 |k 0/700000/ |k 1/700000/721000/ |p 3 |y j | ||
| 999 | |a KXP-PPN1576326063 |e 301260846X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"eki":["1576326063"],"doi":["10.1242/dev.143875"]},"origin":[{"dateIssuedDisp":"2017","dateIssuedKey":"2017"}],"name":{"displayForm":["Christian Hessinger, Gerhard M. Technau and Ana Rogulja-Ortmann"]},"relHost":[{"title":[{"title_sort":"Development","title":"Development"}],"disp":"The Drosophila Hox gene ultrabithorax acts in both muscles and motoneurons to orchestrate formation of specific neuromuscular connectionsDevelopment","type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 26.06.2025"],"recId":"31982439X","corporate":[{"roleDisplay":"Herausgebendes Organ","display":"The Company of Biologists","role":"isb"}],"language":["eng"],"pubHistory":["Volume 99, 1 (January 1987)-"],"titleAlt":[{"title":"Development <Cambridge>"}],"part":{"volume":"144","text":"144(2017), 1, Seite 139-150","extent":"12","year":"2017","issue":"1","pages":"139-150"},"name":{"displayForm":["Company of Biologists"]},"origin":[{"publisherPlace":"Cambridge","dateIssuedDisp":"1987-","publisher":"The Company of Biologists","dateIssuedKey":"1987"}],"id":{"eki":["31982439X"],"zdb":["2007916-3"],"issn":["1477-9129"]},"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"extent":"12 S."}],"title":[{"title_sort":"Drosophila Hox gene ultrabithorax acts in both muscles and motoneurons to orchestrate formation of specific neuromuscular connections","title":"The Drosophila Hox gene ultrabithorax acts in both muscles and motoneurons to orchestrate formation of specific neuromuscular connections"}],"person":[{"role":"aut","display":"Hessinger, Christian","roleDisplay":"VerfasserIn","given":"Christian","family":"Hessinger"},{"display":"Technau, Gerhard","roleDisplay":"VerfasserIn","role":"aut","family":"Technau","given":"Gerhard"},{"family":"Rogulja-Ortmann","given":"Ana","display":"Rogulja-Ortmann, Ana","roleDisplay":"VerfasserIn","role":"aut"}],"recId":"1576326063","language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Published as accepted manuscript 2 December 2016 and published as research article online January 3, 2017","Gesehen am 13.06.2018"]} | ||
| SRT | |a HESSINGERCDROSOPHILA2017 | ||