Different forms of AMPA receptor mediated LTP and their correlation to the spatial working memory formation
Spatial working memory (SWM) and the classical, tetanus-induced long-term potentiation (LTP) at hippocampal CA3/CA1 synapses are dependent on L-α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPARs) containing GluA1 subunits as demonstrated by knockout mice lacking GluA1. In GluA1 knock...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
04 July 2017
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| In: |
Frontiers in molecular neuroscience
Year: 2017, Jahrgang: 10 |
| ISSN: | 1662-5099 |
| DOI: | 10.3389/fnmol.2017.00214 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.3389/fnmol.2017.00214 Verlag, kostenfrei, Volltext: https://www.frontiersin.org/articles/10.3389/fnmol.2017.00214/full 
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| Verfasserangaben: | Derya R. Shimshek, Thorsten Bus, Bettina Schupp, Vidar Jensen, Verena Marx, Liliana E. Layer, Georg Köhr and Rolf Sprengel |
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| 520 | |a Spatial working memory (SWM) and the classical, tetanus-induced long-term potentiation (LTP) at hippocampal CA3/CA1 synapses are dependent on L-α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPARs) containing GluA1 subunits as demonstrated by knockout mice lacking GluA1. In GluA1 knockout mice LTP and SWM deficits could be partially recovered by transgenic re-installation of full-length GluA1 in principle forebrain neurons. Here we partially restored hippocampal LTP in GluA1-deficient mice by forebrain-specific depletion of the GluA2 gene, by the activation of a hypomorphic GluA2(Q) allele and by transgenic expression of PDZ-site truncated GFP-GluA1(TG). In none of these three mouse lines, the partial LTP recovery improved the SWM performance of GluA1-deficient mice suggesting a specific function of intact GluA1/2 receptors and the GluA1 intracellular carboxyl-terminus in SWM and its associated behavior. | ||
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| 650 | 4 | |a long-term potentiation (LTP) | |
| 650 | 4 | |a spatial reference memory (SRM) | |
| 650 | 4 | |a spatial working memory (SWM) | |
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