MR relaxometry of the liver: significant elevation of T1 relaxation time in patients with liver cirrhosis
Objectives: To evaluate hepatic relaxation times T1, T2 and T2* in healthy subjects and patients with liver cirrhosis stratified by the Child-Pugh classification (CPC). Methods: Sixty-one consecutive patients were stratified by CPC (class A = 26; B = 20; C = 15) and compared with age-matched control...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2012
|
| In: |
European radiology
Year: 2012, Jahrgang: 22, Heft: 6, Pages: 1224-1232 |
| ISSN: | 1432-1084 |
| DOI: | 10.1007/s00330-012-2378-5 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1007/s00330-012-2378-5 Verlag, Volltext: https://link.springer.com/article/10.1007/s00330-012-2378-5 
|
| Verfasserangaben: | Tobias Heye, Schu-Ren Yang, Michael Bock, Sylvia Brost, Kilian Weigand, Thomas Longerich, Hans-Ulrich Kauczor, Waldemar Hosch |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1576393879 | ||
| 003 | DE-627 | ||
| 005 | 20220814164025.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180615s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00330-012-2378-5 |2 doi | |
| 035 | |a (DE-627)1576393879 | ||
| 035 | |a (DE-576)506393879 | ||
| 035 | |a (DE-599)BSZ506393879 | ||
| 035 | |a (OCoLC)1341011776 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Heye, Tobias |d 1976- |e VerfasserIn |0 (DE-588)133300943 |0 (DE-627)691326002 |0 (DE-576)271430303 |4 aut | |
| 245 | 1 | 0 | |a MR relaxometry of the liver |b significant elevation of T1 relaxation time in patients with liver cirrhosis |c Tobias Heye, Schu-Ren Yang, Michael Bock, Sylvia Brost, Kilian Weigand, Thomas Longerich, Hans-Ulrich Kauczor, Waldemar Hosch |
| 264 | 1 | |c 2012 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a First online: 03 February 2012 | ||
| 500 | |a Gesehen am 15.06.2018 | ||
| 520 | |a Objectives: To evaluate hepatic relaxation times T1, T2 and T2* in healthy subjects and patients with liver cirrhosis stratified by the Child-Pugh classification (CPC). Methods: Sixty-one consecutive patients were stratified by CPC (class A = 26; B = 20; C = 15) and compared with age-matched controls (n = 31). Relaxometry measurements were performed at 1.5 T using six saturation recovery times (200-3,000 ms) to determine liver T1, six echo times (TE 14-113 ms) for T2 and eight TE (4.8-38 ms) for T2* assessment. Signal intensities in selected regions of interest in the liver parenchyma were fitted to theoretical models with least squares minimisation algorithms to determine T1, T2 and T2*. Results: The most significant difference was the higher T1 values (852 ± 132 ms) in cirrhotic livers compared with controls (678 ± 45 ms, P < 0.0001). A less significant difference was seen for T2* (23 ± 5 vs. 26 ± 7 ms). Subdifferentiation showed a statistically significant difference between control group and individual CPC classes as well as between class C and classes A or B for T1 relaxation times. Conclusion: Measurement of T1 relaxation time can differentiate healthy subjects from patients with liver cirrhosis, and can distinguish between mild/moderate disease (CPC A/B) and advanced disease (CPC C). Key Points: Significantly elevated magnetic resonance T1 relaxation times are found in liver cirrhosis. T1 relaxation times can distinguish healthy subjects from patients with liver cirrhosis. T1 relaxation times can distinguish Child-Pugh classes A and B from C. | ||
| 700 | 1 | |a Yang, Schu-Ren |d 1985- |e VerfasserIn |0 (DE-588)1045187836 |0 (DE-627)77389439X |0 (DE-576)398837821 |4 aut | |
| 700 | 1 | |a Bock, Michael |e VerfasserIn |0 (DE-588)1140749323 |0 (DE-627)898660335 |0 (DE-576)494021470 |4 aut | |
| 700 | 1 | |a Brost, Sylvia |d 1980- |e VerfasserIn |0 (DE-588)133772454 |0 (DE-627)556365828 |0 (DE-576)300089503 |4 aut | |
| 700 | 1 | |a Weigand, Kilian |d 1976- |e VerfasserIn |0 (DE-588)133961508 |0 (DE-627)558836844 |0 (DE-576)278316697 |4 aut | |
| 700 | 1 | |a Longerich, Thomas |d 1974- |e VerfasserIn |0 (DE-588)128494514 |0 (DE-627)373916124 |0 (DE-576)297178059 |4 aut | |
| 700 | 1 | |a Kauczor, Hans-Ulrich |d 1962- |e VerfasserIn |0 (DE-588)139267123 |0 (DE-627)70327113X |0 (DE-576)310955327 |4 aut | |
| 700 | 1 | |a Hosch, Waldemar P. |d 1969- |e VerfasserIn |0 (DE-588)11585696X |0 (DE-627)691639205 |0 (DE-576)290116562 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European radiology |d Berlin : Springer, 1991 |g 22(2012), 6, Seite 1224-1232 |h Online-Ressource |w (DE-627)268757526 |w (DE-600)1472718-3 |w (DE-576)103868070 |x 1432-1084 |7 nnas |a MR relaxometry of the liver significant elevation of T1 relaxation time in patients with liver cirrhosis |
| 773 | 1 | 8 | |g volume:22 |g year:2012 |g number:6 |g pages:1224-1232 |g extent:9 |a MR relaxometry of the liver significant elevation of T1 relaxation time in patients with liver cirrhosis |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00330-012-2378-5 |x Verlag |3 Volltext |
| 856 | 4 | 0 | |u https://link.springer.com/article/10.1007/s00330-012-2378-5 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180615 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 11585696X |a Hosch, Waldemar P. |m 11585696X:Hosch, Waldemar P. |d 910000 |d 911400 |e 910000PH11585696X |e 911400PH11585696X |k 0/910000/ |k 1/910000/911400/ |p 8 |y j | ||
| 998 | |g 139267123 |a Kauczor, Hans-Ulrich |m 139267123:Kauczor, Hans-Ulrich |d 910000 |d 911400 |e 910000PK139267123 |e 911400PK139267123 |k 0/910000/ |k 1/910000/911400/ |p 7 | ||
| 998 | |g 128494514 |a Longerich, Thomas |m 128494514:Longerich, Thomas |d 910000 |d 912000 |e 910000PL128494514 |e 912000PL128494514 |k 0/910000/ |k 1/910000/912000/ |p 6 | ||
| 998 | |g 133961508 |a Weigand, Kilian |m 133961508:Weigand, Kilian |d 910000 |d 910100 |e 910000PW133961508 |e 910100PW133961508 |k 0/910000/ |k 1/910000/910100/ |p 5 | ||
| 998 | |g 133772454 |a Brost, Sylvia |m 133772454:Brost, Sylvia |d 910000 |d 910100 |e 910000PB133772454 |e 910100PB133772454 |k 0/910000/ |k 1/910000/910100/ |p 4 | ||
| 998 | |g 1140749323 |a Bock, Michael |m 1140749323:Bock, Michael |d 50000 |e 50000PB1140749323 |k 0/50000/ |p 3 | ||
| 998 | |g 1045187836 |a Yang, Schu-Ren |m 1045187836:Yang, Schu-Ren |d 910000 |d 911400 |e 910000PY1045187836 |e 911400PY1045187836 |k 0/910000/ |k 1/910000/911400/ |p 2 | ||
| 998 | |g 133300943 |a Heye, Tobias |m 133300943:Heye, Tobias |d 910000 |d 911400 |e 910000PH133300943 |e 911400PH133300943 |k 0/910000/ |k 1/910000/911400/ |p 1 |x j | ||
| 999 | |a KXP-PPN1576393879 |e 3012725520 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"9 S."}],"recId":"1576393879","relHost":[{"disp":"MR relaxometry of the liver significant elevation of T1 relaxation time in patients with liver cirrhosisEuropean radiology","recId":"268757526","physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"European radiology","title":"European radiology","subtitle":"official organ of the European Association of Radiology"}],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 06.02.2018","Ungezählte Beil.: Supplement"],"origin":[{"publisherPlace":"Berlin ; Heidelberg","dateIssuedKey":"1991","dateIssuedDisp":"1991-","publisher":"Springer"}],"id":{"eki":["268757526"],"issn":["1432-1084","1613-3757"],"zdb":["1472718-3"]},"part":{"volume":"22","year":"2012","issue":"6","extent":"9","text":"22(2012), 6, Seite 1224-1232","pages":"1224-1232"},"pubHistory":["1.1991 -"],"titleAlt":[{"title":"European radiology / Supplement"},{"title":"European radiology supplements"}],"corporate":[{"role":"isb","display":"European Association of Radiology"}]}],"person":[{"family":"Heye","role":"aut","given":"Tobias","display":"Heye, Tobias"},{"given":"Schu-Ren","role":"aut","family":"Yang","display":"Yang, Schu-Ren"},{"family":"Bock","role":"aut","given":"Michael","display":"Bock, Michael"},{"display":"Brost, Sylvia","family":"Brost","role":"aut","given":"Sylvia"},{"role":"aut","given":"Kilian","family":"Weigand","display":"Weigand, Kilian"},{"display":"Longerich, Thomas","family":"Longerich","role":"aut","given":"Thomas"},{"family":"Kauczor","role":"aut","given":"Hans-Ulrich","display":"Kauczor, Hans-Ulrich"},{"display":"Hosch, Waldemar P.","role":"aut","given":"Waldemar P.","family":"Hosch"}],"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"2012"}],"note":["First online: 03 February 2012","Gesehen am 15.06.2018"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"title":[{"title_sort":"MR relaxometry of the liver","title":"MR relaxometry of the liver","subtitle":"significant elevation of T1 relaxation time in patients with liver cirrhosis"}],"name":{"displayForm":["Tobias Heye, Schu-Ren Yang, Michael Bock, Sylvia Brost, Kilian Weigand, Thomas Longerich, Hans-Ulrich Kauczor, Waldemar Hosch"]},"id":{"doi":["10.1007/s00330-012-2378-5"],"eki":["1576393879"]}} | ||
| SRT | |a HEYETOBIASMRRELAXOME2012 | ||