Regulation of DNA-End resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair
Summary: DNA double-strand break (DSB) signaling and repair are critical for cell viability, and rely on highly coordinated pathways whose molecular organization is still incompletely understood. Here, we show that heterogeneous nuclear ribonucleoprotein U-like (hnRNPUL) proteins 1 and 2 play key ro...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2012
|
| In: |
Molecular cell
Year: 2012, Jahrgang: 45, Heft: 4, Pages: 505-516 |
| ISSN: | 1097-4164 |
| DOI: | 10.1016/j.molcel.2011.12.035 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1016/j.molcel.2011.12.035 Verlag, kostenfrei, Volltext: http://www.sciencedirect.com/science/article/pii/S1097276512000457 
|
| Verfasserangaben: | Sophie E. Polo, Andrew N. Blackford, J. Ross Chapman, Linda Baskcomb, Serge Gravel, Andre Rusch, Anoushka Thomas, Rachel Blundred, Philippa Smith, Julia Kzhyshkowska, Thomas Dobner, A. Malcolm R. Taylor, Andrew S. Turnell, Grant S. Stewart, Roger J. Grand and Stephen P. Jackson |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1576399761 | ||
| 003 | DE-627 | ||
| 005 | 20250206095648.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180615s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.molcel.2011.12.035 |2 doi | |
| 035 | |a (DE-627)1576399761 | ||
| 035 | |a (DE-576)506399761 | ||
| 035 | |a (DE-599)BSZ506399761 | ||
| 035 | |a (OCoLC)1341011532 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Polo, Sophie E. |e VerfasserIn |0 (DE-588)1161193766 |0 (DE-627)1024608956 |0 (DE-576)506399605 |4 aut | |
| 245 | 1 | 0 | |a Regulation of DNA-End resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair |c Sophie E. Polo, Andrew N. Blackford, J. Ross Chapman, Linda Baskcomb, Serge Gravel, Andre Rusch, Anoushka Thomas, Rachel Blundred, Philippa Smith, Julia Kzhyshkowska, Thomas Dobner, A. Malcolm R. Taylor, Andrew S. Turnell, Grant S. Stewart, Roger J. Grand and Stephen P. Jackson |
| 264 | 1 | |c 2012 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online 23 February | ||
| 500 | |a Gesehen am 15.06.2018 | ||
| 520 | |a Summary: DNA double-strand break (DSB) signaling and repair are critical for cell viability, and rely on highly coordinated pathways whose molecular organization is still incompletely understood. Here, we show that heterogeneous nuclear ribonucleoprotein U-like (hnRNPUL) proteins 1 and 2 play key roles in cellular responses to DSBs. We identify human hnRNPUL1 and -2 as binding partners for the DSB sensor complex MRE11-RAD50-NBS1 (MRN) and demonstrate that hnRNPUL1 and -2 are recruited to DNA damage in an interdependent manner that requires MRN. Moreover, we show that hnRNPUL1 and -2 stimulate DNA-end resection and promote ATR-dependent signaling and DSB repair by homologous recombination, thereby contributing to cell survival upon exposure to DSB-inducing agents. Finally, we establish that hnRNPUL1 and -2 function downstream of MRN and CtBP-interacting protein (CtIP) to promote recruitment of the BLM helicase to DNA breaks. Collectively, these results provide insights into how mammalian cells respond to DSBs. | ||
| 700 | 1 | |a Kzhyshkowska, Julia |d 1967- |e VerfasserIn |0 (DE-588)102414271X |0 (DE-627)719213754 |0 (DE-576)368002233 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Molecular cell |d [Cambridge, Mass.] : Cell Press, 1997 |g 45(2012), 4, Seite 505-516 |h Online-Ressource |w (DE-627)320416097 |w (DE-600)2001948-8 |w (DE-576)090881362 |x 1097-4164 |7 nnas |a Regulation of DNA-End resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair |
| 773 | 1 | 8 | |g volume:45 |g year:2012 |g number:4 |g pages:505-516 |g extent:12 |a Regulation of DNA-End resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.molcel.2011.12.035 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S1097276512000457 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180615 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 102414271X |a Kzhyshkowska, Julia |m 102414271X:Kzhyshkowska, Julia |d 60000 |d 61900 |e 60000PK102414271X |e 61900PK102414271X |k 0/60000/ |k 1/60000/61900/ |p 10 | ||
| 999 | |a KXP-PPN1576399761 |e 3012733434 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"12 S."}],"recId":"1576399761","note":["Available online 23 February","Gesehen am 15.06.2018"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"title":[{"title_sort":"Regulation of DNA-End resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair","title":"Regulation of DNA-End resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair"}],"relHost":[{"pubHistory":["1.1997/98 -"],"origin":[{"publisher":"Cell Press ; Elsevier","dateIssuedKey":"1997","publisherPlace":"[Cambridge, Mass.] ; New York, NY","dateIssuedDisp":"1997-"}],"part":{"extent":"12","text":"45(2012), 4, Seite 505-516","issue":"4","pages":"505-516","volume":"45","year":"2012"},"title":[{"title":"Molecular cell","title_sort":"Molecular cell"}],"id":{"zdb":["2001948-8"],"eki":["320416097"],"issn":["1097-4164"]},"note":["Gesehen am 01.08.25"],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"320416097","physDesc":[{"extent":"Online-Ressource"}],"disp":"Regulation of DNA-End resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repairMolecular cell"}],"person":[{"display":"Polo, Sophie E.","family":"Polo","given":"Sophie E.","role":"aut"},{"given":"Julia","role":"aut","family":"Kzhyshkowska","display":"Kzhyshkowska, Julia"}],"origin":[{"dateIssuedDisp":"2012","dateIssuedKey":"2012"}],"id":{"doi":["10.1016/j.molcel.2011.12.035"],"eki":["1576399761"]},"name":{"displayForm":["Sophie E. Polo, Andrew N. Blackford, J. Ross Chapman, Linda Baskcomb, Serge Gravel, Andre Rusch, Anoushka Thomas, Rachel Blundred, Philippa Smith, Julia Kzhyshkowska, Thomas Dobner, A. Malcolm R. Taylor, Andrew S. Turnell, Grant S. Stewart, Roger J. Grand and Stephen P. Jackson"]}} | ||
| SRT | |a POLOSOPHIEREGULATION2012 | ||