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Zwitterionic modification of ultrasmall iron oxide nanoparticles for reduced protein corona formation

Polyacrylic-acid-coated ultra-small super-paramagnetic iron oxide nanoparticles were surface-modified with low-molecular-weight sulfobetaines or 3-(diethylamino)propylamine in order to generate nanoparticles with zwitterionic character (ZW-NPs). The ZW-NPs proved highly resistant to serum protein co...

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Bibliographic Details
Main Authors: Pombo García, Karina (Author) , Comba, Peter (Author)
Format: Article (Journal)
Language:English
Published: 2017
In: ChemPlusChem
Year: 2017, Volume: 82, Issue: 4, Pages: 638-646
ISSN:2192-6506
DOI:10.1002/cplu.201700052
Online Access:Verlag, Volltext: http://dx.doi.org/10.1002/cplu.201700052
Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/cplu.201700052
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Author Notes:Karina Pombo‐García, Carmen L. Rühl, Raymond Lam, José A. Barreto, Ching-Seng Ang, Peter J. Scammells, Peter Comba, Leone Spiccia †, Bim Graham, Tanmaya Joshi and Holger Stephan

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520 |a Polyacrylic-acid-coated ultra-small super-paramagnetic iron oxide nanoparticles were surface-modified with low-molecular-weight sulfobetaines or 3-(diethylamino)propylamine in order to generate nanoparticles with zwitterionic character (ZW-NPs). The ZW-NPs proved highly resistant to serum protein corona formation in vitro, as revealed by atomic force microscopy, SDS-PAGE and proteomics analysis, and exhibited low cytotoxicity towards A431 and HEK293 cells. The presence of unreacted carboxylic acid groups enabled additional functionalization with fluorescent (Cy5) and radioactive [64Cu-dmptacn; dmptacn=1,4-bis(2-pyridinylmethyl)-1,4,7-triazacyclononane] moieties. Overall, the ZW-NPs represent promising platforms for the development of new multimodal diagnostic/therapeutic agents possessing “stealth” properties. 
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