STZ causes depletion of immune cells in sciatic nerve and dorsal root ganglion in experimental diabetes
Streptozotocin (STZ) treatment, a common model for inducing diabetes in rodent models, induces thermal hyperalgesia and neuronal toxicity independently of hyperglycemia by oxidizing and activating TRPA1 and TRPV1. Following treatment with STZ, CD45+ immune cells were found to be depleted in sciatic...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2017
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| In: |
Journal of neuroimmunology
Year: 2017, Volume: 306, Pages: 76-82 |
| ISSN: | 1872-8421 |
| DOI: | 10.1016/j.jneuroim.2017.03.008 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.jneuroim.2017.03.008 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S016557281630248X 
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| Author Notes: | Asa S. Hidmark, Peter P. Nawroth, Thomas Fleming |
| Summary: | Streptozotocin (STZ) treatment, a common model for inducing diabetes in rodent models, induces thermal hyperalgesia and neuronal toxicity independently of hyperglycemia by oxidizing and activating TRPA1 and TRPV1. Following treatment with STZ, CD45+ immune cells were found to be depleted in sciatic nerve (SN) and DRG in mice, prior to hyperglycemia. Macrophages were also lost in DRG and NFκB-p65-activation was increased in SN macrophages. Immune cells were significantly reduced in both SN and DRG up to three weeks, post-treatment. Loss of PNS-resident macrophages in response to STZ-mediated toxicity may affect the regenerative capacity of the nerve in response to further injury caused by diabetes. |
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| Item Description: | Available online 11 March 2017 Gesehen am 15.06.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1872-8421 |
| DOI: | 10.1016/j.jneuroim.2017.03.008 |