Clusters of spreading depolarizations are associated with disturbed cerebral metabolism in patients with aneurysmal subarachnoid hemorrhage
Background and Purpose—We studied the dynamics of extracellular brain tissue concentrations of glucose, lactate, pyruvate, and glutamate during the occurrence of spreading depolarizations (SDs) in patients with aneurysmal subarachnoid hemorrhage. Methods—In this prospective observational study, pati...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2013
|
| In: |
Stroke
Year: 2012, Jahrgang: 44, Heft: 1, Pages: 220-223 |
| ISSN: | 1524-4628 |
| DOI: | 10.1161/STROKEAHA.112.672352 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1161/STROKEAHA.112.672352 Verlag, Volltext: http://stroke.ahajournals.org/content/44/1/220 
|
| Verfasserangaben: | Oliver W. Sakowitz, Edgar Santos, Alexandra Nagel, Kara L. Krajewski, Daniel N. Hertle, Peter Vajkoczy, Jens P. Dreier, Andreas W. Unterberg, Asita S. Sarrafzadeh |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1576457958 | ||
| 003 | DE-627 | ||
| 005 | 20220814165122.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180618r20132012xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1161/STROKEAHA.112.672352 |2 doi | |
| 035 | |a (DE-627)1576457958 | ||
| 035 | |a (DE-576)506457958 | ||
| 035 | |a (DE-599)BSZ506457958 | ||
| 035 | |a (OCoLC)1341011779 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Sakowitz, Oliver |d 1971- |e VerfasserIn |0 (DE-588)123767075 |0 (DE-627)706419928 |0 (DE-576)293869189 |4 aut | |
| 245 | 1 | 0 | |a Clusters of spreading depolarizations are associated with disturbed cerebral metabolism in patients with aneurysmal subarachnoid hemorrhage |c Oliver W. Sakowitz, Edgar Santos, Alexandra Nagel, Kara L. Krajewski, Daniel N. Hertle, Peter Vajkoczy, Jens P. Dreier, Andreas W. Unterberg, Asita S. Sarrafzadeh |
| 264 | 1 | |c 2013 | |
| 300 | |a 4 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Originally published 6 Dec 2012 | ||
| 500 | |a Gesehen am 18.06.2018 | ||
| 520 | |a Background and Purpose—We studied the dynamics of extracellular brain tissue concentrations of glucose, lactate, pyruvate, and glutamate during the occurrence of spreading depolarizations (SDs) in patients with aneurysmal subarachnoid hemorrhage. Methods—In this prospective observational study, patients with aneurysmal subarachnoid hemorrhage received multimodal cerebral monitoring, including intracranial pressure, cerebral microdialysis, and subdural electrocorticography. Results—Seven of the 17 recruited patients had intracerebral hemorrhage, acute ischemia and severe brain oedema leading to acute ischemic neurological deficits associated with early disturbance of metabolism at the recording site. They displayed a total of 130 SDs. The remaining 10 patients without acute ischemic neurological deficits exhibited 138 single SDs and 68 SDs in clusters. In patients without acute ischemic neurological deficits, clustered SDs were associated with a significant transient decrease in glucose and increase in lactate compared with baseline during the first 140 minutes after SDs. Moreover, the number of clustered SDs correlated with the outcome (R=−0.659; P<0.01). Conclusion—SDs can propagate in nonischemic human brain tissue. Clusters of SDs are related to metabolic changes suggestive of ongoing secondary damage in primarily nonischemic brain tissue. | ||
| 534 | |c 2012 | ||
| 650 | 4 | |a aneurysms | |
| 650 | 4 | |a cerebrovascular disease | |
| 650 | 4 | |a delayed cerebral ischemia | |
| 650 | 4 | |a energy metabolism | |
| 650 | 4 | |a focal ischemia | |
| 650 | 4 | |a glucose | |
| 650 | 4 | |a spreading depolarization | |
| 700 | 1 | |a Santos, Edgar |d 1982- |e VerfasserIn |0 (DE-588)1048580407 |0 (DE-627)780674537 |0 (DE-576)402410882 |4 aut | |
| 700 | 1 | |a Krajewski, Kara Leigh |d 1982- |e VerfasserIn |0 (DE-588)143524496 |0 (DE-627)647311895 |0 (DE-576)337520224 |4 aut | |
| 700 | 1 | |a Hertle, Daniel |e VerfasserIn |0 (DE-588)1126661627 |0 (DE-627)881250503 |0 (DE-576)484643452 |4 aut | |
| 700 | 1 | |a Vajkoczy, Peter |d 1968- |e VerfasserIn |0 (DE-588)115313885 |0 (DE-627)537492593 |0 (DE-576)289826012 |4 aut | |
| 700 | 1 | |a Unterberg, Andreas |e VerfasserIn |0 (DE-588)1032681187 |0 (DE-627)738641200 |0 (DE-576)168441233 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Stroke |d New York, NY : Association, 1970 |g 44(2013), 1, Seite 220-223 |h Online-Ressource |w (DE-627)266879985 |w (DE-600)1467823-8 |w (DE-576)075145731 |x 1524-4628 |7 nnas |a Clusters of spreading depolarizations are associated with disturbed cerebral metabolism in patients with aneurysmal subarachnoid hemorrhage |
| 773 | 1 | 8 | |g volume:44 |g year:2013 |g number:1 |g pages:220-223 |g extent:4 |a Clusters of spreading depolarizations are associated with disturbed cerebral metabolism in patients with aneurysmal subarachnoid hemorrhage |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1161/STROKEAHA.112.672352 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://stroke.ahajournals.org/content/44/1/220 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180618 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 1032681187 |a Unterberg, Andreas |m 1032681187:Unterberg, Andreas |d 910000 |d 911200 |e 910000PU1032681187 |e 911200PU1032681187 |k 0/910000/ |k 1/910000/911200/ |p 8 | ||
| 998 | |g 1126661627 |a Hertle, Daniel |m 1126661627:Hertle, Daniel |d 910000 |d 911200 |e 910000PH1126661627 |e 911200PH1126661627 |k 0/910000/ |k 1/910000/911200/ |p 5 | ||
| 998 | |g 143524496 |a Krajewski, Kara Leigh |m 143524496:Krajewski, Kara Leigh |d 910000 |d 911200 |e 910000PK143524496 |e 911200PK143524496 |k 0/910000/ |k 1/910000/911200/ |p 4 | ||
| 998 | |g 1048580407 |a Santos, Edgar |m 1048580407:Santos, Edgar |d 910000 |d 911200 |e 910000PS1048580407 |e 911200PS1048580407 |k 0/910000/ |k 1/910000/911200/ |p 2 | ||
| 998 | |g 123767075 |a Sakowitz, Oliver |m 123767075:Sakowitz, Oliver |d 910000 |d 911200 |e 910000PS123767075 |e 911200PS123767075 |k 0/910000/ |k 1/910000/911200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1576457958 |e 3012865705 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1576457958","name":{"displayForm":["Oliver W. Sakowitz, Edgar Santos, Alexandra Nagel, Kara L. Krajewski, Daniel N. Hertle, Peter Vajkoczy, Jens P. Dreier, Andreas W. Unterberg, Asita S. Sarrafzadeh"]},"note":["Originally published 6 Dec 2012","Gesehen am 18.06.2018"],"origin":[{"dateIssuedDisp":"2013","dateIssuedKey":"2013"}],"language":["eng"],"person":[{"role":"aut","display":"Sakowitz, Oliver","given":"Oliver","family":"Sakowitz"},{"family":"Santos","given":"Edgar","display":"Santos, Edgar","role":"aut"},{"family":"Krajewski","given":"Kara Leigh","display":"Krajewski, Kara Leigh","role":"aut"},{"family":"Hertle","given":"Daniel","display":"Hertle, Daniel","role":"aut"},{"role":"aut","display":"Vajkoczy, Peter","given":"Peter","family":"Vajkoczy"},{"given":"Andreas","family":"Unterberg","role":"aut","display":"Unterberg, Andreas"}],"id":{"eki":["1576457958"],"doi":["10.1161/STROKEAHA.112.672352"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"4 S."}],"relHost":[{"corporate":[{"role":"isb","display":"American Heart Association"}],"disp":"Clusters of spreading depolarizations are associated with disturbed cerebral metabolism in patients with aneurysmal subarachnoid hemorrhageStroke","note":["Gesehen am 29.06.04"],"title":[{"title":"Stroke","subtitle":"journal of the American Heart Association","title_sort":"Stroke"}],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"origin":[{"publisherPlace":"New York, NY ; Philadelphia, Pa.","dateIssuedKey":"1970","publisher":"Association ; Lippincott Williams & Wilkins","dateIssuedDisp":"1970-"}],"recId":"266879985","pubHistory":["1.1970 -"],"part":{"text":"44(2013), 1, Seite 220-223","pages":"220-223","issue":"1","extent":"4","year":"2013","volume":"44"},"id":{"eki":["266879985"],"zdb":["1467823-8"],"issn":["1524-4628"]},"type":{"media":"Online-Ressource","bibl":"periodical"}}],"title":[{"title":"Clusters of spreading depolarizations are associated with disturbed cerebral metabolism in patients with aneurysmal subarachnoid hemorrhage","title_sort":"Clusters of spreading depolarizations are associated with disturbed cerebral metabolism in patients with aneurysmal subarachnoid hemorrhage"}]} | ||
| SRT | |a SAKOWITZOLCLUSTERSOF2013 | ||