Multiple essential roles for primary cilia in heart development
The primary cilium is a microtubule-based, plasma membrane-ensheathed protrusion projecting from the basal bodies of almost all cell types in the mammalian body. In the past several years a plethora of papers has indicated a crucial role for primary cilia in the development of a wide variety of orga...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2012
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| In: |
Cilia
Year: 2012, Jahrgang: 1, Pages: 23 |
| ISSN: | 2046-2530 |
| DOI: | 10.1186/2046-2530-1-23 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/2046-2530-1-23 Verlag, kostenfrei, Volltext: https://doi.org/10.1186/2046-2530-1-23 
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| Verfasserangaben: | Marc August Willaredt, Karin Gorgas, Humphrey A.R. Gardner, Kerry L. Tucker |
| Zusammenfassung: | The primary cilium is a microtubule-based, plasma membrane-ensheathed protrusion projecting from the basal bodies of almost all cell types in the mammalian body. In the past several years a plethora of papers has indicated a crucial role for primary cilia in the development of a wide variety of organs. We have investigated heart development in cobblestone, a hypomorphic allele of the gene encoding the intraflagellar transport protein Ift88, and uncovered a number of the most common congenital heart defects seen in newborn humans. |
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| Beschreibung: | Published: 11 December 2012 Gesehen am 18.06.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 2046-2530 |
| DOI: | 10.1186/2046-2530-1-23 |