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Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability

Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tumor with largely unknown biology. Here, the authors perform genome- and epigenome-wide analyses from normal and ACC pancreatic tissue that identify aberrations in genome stability and cell cycle control.

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Bibliographic Details
Main Authors: Jäkel, Cornelia (Author) , Bergmann, Frank (Author) , Strobel, Oliver (Author) , Hank, Thomas (Author) , Schirmacher, Peter (Author)
Format: Article (Journal)
Language:English
Published: 06 November 2017
In: Nature Communications
Year: 2017, Volume: 8, Issue: 1
ISSN:2041-1723
DOI:10.1038/s41467-017-01118-x
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/s41467-017-01118-x
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-017-01118-x
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Author Notes:Cornelia Jäkel, Frank Bergmann, Reka Toth, Yassen Assenov, Daniel van der Duin, Oliver Strobel, Thomas Hank, Günter Klöppel, Craig Dorrell, Markus Grompe, Joshua Moss, Yuval Dor, Peter Schirmacher, Christoph Plass, Odilia Popanda, Peter Schmezer
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Summary:Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tumor with largely unknown biology. Here, the authors perform genome- and epigenome-wide analyses from normal and ACC pancreatic tissue that identify aberrations in genome stability and cell cycle control.
Item Description:Gesehen am 18.06.2018
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-017-01118-x

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