Prediction of response and prognosis by a score including only pretherapeutic parameters in 410 neoadjuvant treated gastric cancer patients
Introduction: Response to neoadjuvant chemotherapy (NAC) is an independent prognostic factor in locally advanced gastric cancer. However, no prospectively tested pretherapeutic parameters predicting response and/or survival in gastric cancer are available in clinical routine. Patients and methods: W...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Chapter/Article Conference Paper |
| Language: | English |
| Published: |
2012
|
| In: |
Early gastrointestinal cancers
Year: 2012, Pages: 269-289 |
| DOI: | 10.1007/978-3-642-31629-6_18 |
| Subjects: | |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1007/978-3-642-31629-6_18 Verlag, Volltext: https://link.springer.com/chapter/10.1007/978-3-642-31629-6_18 
|
| Author Notes: | Lorenzen Sylvie, Blank Susanne, Ott Katja |
MARC
| LEADER | 00000caa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1576748464 | ||
| 003 | DE-627 | ||
| 005 | 20220814172101.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180621s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/978-3-642-31629-6_18 |2 doi | |
| 035 | |a (DE-627)1576748464 | ||
| 035 | |a (DE-576)506748464 | ||
| 035 | |a (DE-599)BSZ506748464 | ||
| 035 | |a (OCoLC)1341012187 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Lorenzen, Sylvie |d 1973- |e VerfasserIn |0 (DE-588)128891106 |0 (DE-627)384629202 |0 (DE-576)297385739 |4 aut | |
| 245 | 1 | 0 | |a Prediction of response and prognosis by a score including only pretherapeutic parameters in 410 neoadjuvant treated gastric cancer patients |c Lorenzen Sylvie, Blank Susanne, Ott Katja |
| 264 | 1 | |c 2012 | |
| 300 | |a 21 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a First online: 06 November 2012 | ||
| 500 | |a Original paper is published in Ann Surg Oncol. 2012 Mar 7 [Epub ahead of print] | ||
| 500 | |a Gesehen am 21.06.2018 | ||
| 520 | |a Introduction: Response to neoadjuvant chemotherapy (NAC) is an independent prognostic factor in locally advanced gastric cancer. However, no prospectively tested pretherapeutic parameters predicting response and/or survival in gastric cancer are available in clinical routine. Patients and methods: We evaluated the prognostic significance of various clinicopathologic parameters in 410 patients who were treated with NAC followed by gastrectomy. Clinical and histopathological response evaluation was performed using standardized criteria. A prognostic score was created on the basis of the variables identified in the multivariate analysis. Results: Multivariate analysis identified three pretherapeutic parameters as positive predictive factors for response and prognosis: tumor localization in the middle third of the stomach (p = 0.001), well differentiated tumors (p = 0.001) and intestinal tumor type according to Laurén’s classification (p = 0.03). From the obtained data a prognostic index was constructed, dividing the patients into three risk groups: low (n = 73), intermediate (n = 274), and poor (n = 63). The three groups had significantly different clinical (p = 0.007) and histopathological response rates (p = 0.001) and survival times, with a median survival time that was not reached in the low-risk group, 39.2 months in the intermediate-risk group and 20.5 months in the poor-risk group. The corresponding 5-year survival rates were 65.3, 41.2, and 21.2 % (p < 0.001), respectively. Conclusion: A simple scoring system based on three clinicopathologic parameters, accurately predicts response and prognosis in neoadjuvant treated gastric cancer. This system provides additional useful information that could be applied to select gastric cancer patients pretherapeutically for different treatment approaches. Prospective testing of the score in an independent patient cohort is warranted. | ||
| 655 | 7 | |a Konferenzschrift |0 (DE-588)1071861417 |0 (DE-627)826484824 |0 (DE-576)433375485 |2 gnd-content | |
| 700 | 1 | |a Blank, Susanne |d 1984- |e VerfasserIn |0 (DE-588)1014414253 |0 (DE-627)705225097 |0 (DE-576)34875714X |4 aut | |
| 700 | 1 | |a Ott, Katja |d 1971- |e VerfasserIn |0 (DE-588)118131257 |0 (DE-627)079261914 |0 (DE-576)291731244 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Early gastrointestinal cancers |d Berlin, Heidelberg : Springer Berlin Heidelberg, 2012 |g (2012), Seite 269-289 |h Online-Ressource (XII, 318 Seiten) |w (DE-627)1654502278 |w (DE-576)507548574 |z 9783642316296 |7 nnam |a Prediction of response and prognosis by a score including only pretherapeutic parameters in 410 neoadjuvant treated gastric cancer patients |
| 773 | 1 | 8 | |g year:2012 |g pages:269-289 |g extent:21 |a Prediction of response and prognosis by a score including only pretherapeutic parameters in 410 neoadjuvant treated gastric cancer patients |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/978-3-642-31629-6_18 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://link.springer.com/chapter/10.1007/978-3-642-31629-6_18 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180621 | ||
| 993 | |a ConferencePaper | ||
| 994 | |a 2012 | ||
| 998 | |g 118131257 |a Ott, Katja |m 118131257:Ott, Katja |d 910000 |d 910200 |e 910000PO118131257 |e 910200PO118131257 |k 0/910000/ |k 1/910000/910200/ |p 3 |y j | ||
| 998 | |g 1014414253 |a Blank, Susanne |m 1014414253:Blank, Susanne |d 910000 |d 910200 |e 910000PB1014414253 |e 910200PB1014414253 |k 0/910000/ |k 1/910000/910200/ |p 2 | ||
| 998 | |g 128891106 |a Lorenzen, Sylvie |m 128891106:Lorenzen, Sylvie |d 910000 |e 910000PL128891106 |k 0/910000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1576748464 |e 3013349050 | ||
| BIB | |a Y | ||
| JSO | |a {"relHost":[{"relMultPart":[{"disp":"Recent results in cancer research","title":[{"title":"Recent results in cancer research","title_sort":"Recent results in cancer research","subtitle":" = Fortschritte der Krebsforschung = Progrès dans les recherches sur le cancer"}],"type":{"bibl":"serial"},"language":["ger"],"titleTranslated":[{"translated":"Fortschritte der Krebsforschung"},{"translated":"Progrès dans les recherches sur le cancer"}],"dispAlt":"Recent results in cancer research","recId":"130187909","pubHistory":["1.1965 -"],"part":{"number_sort":["196,onli"],"number":["196"]},"origin":[{"publisherPlace":"Berlin ; Heidelberg ; New York","dateIssuedKey":"1965","publisher":"Springer","dateIssuedDisp":"1965-"}],"id":{"eki":["130187909"],"zdb":["528441-7"],"issn":["0080-0015"]}}],"origin":[{"publisherPlace":"Berlin, Heidelberg","dateIssuedKey":"2012","dateIssuedDisp":"2012","publisher":"Springer Berlin Heidelberg"}],"corporate":[{"role":"oth","display":"St. Gallen EORTC Gastrointestinal Cancer Conference (1., 2012, Sankt Gallen)"}],"part":{"text":"(2012), Seite 269-289","extent":"21","year":"2012","pages":"269-289"},"recId":"1654502278","person":[{"roleDisplay":"Hrsg.","role":"edt","family":"Otto","display":"Otto, Florian","given":"Florian"}],"title":[{"title_sort":"Early gastrointestinal cancers","title":"Early gastrointestinal cancers"}],"note":["Lizenzpflichtig"],"id":{"uri":["urn:nbn:de:1111-2012110692"],"isbn":["9783642316296"],"eki":["1654502278"]},"type":{"media":"Online-Ressource","bibl":"edited-book"},"language":["ger"],"disp":"Prediction of response and prognosis by a score including only pretherapeutic parameters in 410 neoadjuvant treated gastric cancer patientsEarly gastrointestinal cancers","physDesc":[{"extent":"Online-Ressource (XII, 318 Seiten)"}]}],"physDesc":[{"extent":"21 S."}],"type":{"media":"Online-Ressource","bibl":"chapter"},"title":[{"title":"Prediction of response and prognosis by a score including only pretherapeutic parameters in 410 neoadjuvant treated gastric cancer patients","title_sort":"Prediction of response and prognosis by a score including only pretherapeutic parameters in 410 neoadjuvant treated gastric cancer patients"}],"language":["eng"],"person":[{"roleDisplay":"VerfasserIn","role":"aut","family":"Lorenzen","display":"Lorenzen, Sylvie","given":"Sylvie"},{"family":"Blank","role":"aut","roleDisplay":"VerfasserIn","given":"Susanne","display":"Blank, Susanne"},{"display":"Ott, Katja","given":"Katja","roleDisplay":"VerfasserIn","family":"Ott","role":"aut"}],"recId":"1576748464","note":["First online: 06 November 2012","Original paper is published in Ann Surg Oncol. 2012 Mar 7 [Epub ahead of print]","Gesehen am 21.06.2018"],"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"2012"}],"id":{"eki":["1576748464"],"doi":["10.1007/978-3-642-31629-6_18"]},"name":{"displayForm":["Lorenzen Sylvie, Blank Susanne, Ott Katja"]}} | ||
| SRT | |a LORENZENSYPREDICTION2012 | ||