Mesenchymal stromal cells (MSCs): science and f(r)iction
Due to their multi-lineage differentiation capacity, support of haematopoiesis, immunomodulation and secretion of proregenerative factors, mesenchymal stem/stromal cells (MSCs) are in the focus of intense research since decades. The literature is replete with reports on their potential in preclinica...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2012
|
| In: |
Journal of molecular medicine
Year: 2012, Jahrgang: 90, Heft: 7, Pages: 773-782 |
| ISSN: | 1432-1440 |
| DOI: | 10.1007/s00109-012-0915-y |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1007/s00109-012-0915-y Verlag, Volltext: https://link.springer.com/article/10.1007/s00109-012-0915-y 
|
| Verfasserangaben: | Karen Bieback, Patrick Wuchter, Daniel Besser, Werner Franke, Matthias Becker, Michael Ott, Martin Pacher, Nan Ma, Christof Stamm, Harald Klüter, Albrecht Müller, Anthony D. Ho for the START-MSC consortium |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1576815757 | ||
| 003 | DE-627 | ||
| 005 | 20220814173503.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180625s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00109-012-0915-y |2 doi | |
| 035 | |a (DE-627)1576815757 | ||
| 035 | |a (DE-576)506815757 | ||
| 035 | |a (DE-599)BSZ506815757 | ||
| 035 | |a (OCoLC)1341012348 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bieback, Karen |d 1972- |e VerfasserIn |0 (DE-588)124509991 |0 (DE-627)376254653 |0 (DE-576)294206604 |4 aut | |
| 245 | 1 | 0 | |a Mesenchymal stromal cells (MSCs) |b science and f(r)iction |c Karen Bieback, Patrick Wuchter, Daniel Besser, Werner Franke, Matthias Becker, Michael Ott, Martin Pacher, Nan Ma, Christof Stamm, Harald Klüter, Albrecht Müller, Anthony D. Ho for the START-MSC consortium |
| 264 | 1 | |c 2012 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published online: 31 May 2012 | ||
| 500 | |a Gesehen am 25.06.2018 | ||
| 520 | |a Due to their multi-lineage differentiation capacity, support of haematopoiesis, immunomodulation and secretion of proregenerative factors, mesenchymal stem/stromal cells (MSCs) are in the focus of intense research since decades. The literature is replete with reports on their potential in preclinical model systems. However, the heterogeneity of the primary cell population as starting material and the diverse protocols for isolation and cultivation are hampering progress in their clinical application. Consensus on common standards and harmonised isolation and characterisation protocols are important to ensure safety and efficacy. This review focuses on the recent scientific evidence of clinically relevant properties and on the speculative cardiomyogenic and hepatic differentiation potential of MSCs. Special emphasis is put on the importance of standardisation and harmonisation in clinical-scale manufacturing. | ||
| 700 | 1 | |a Wuchter, Patrick |d 1975- |e VerfasserIn |0 (DE-588)123450284 |0 (DE-627)082563624 |0 (DE-576)184642574 |4 aut | |
| 700 | 1 | |a Klüter, Harald |e VerfasserIn |0 (DE-588)1026722470 |0 (DE-627)727105132 |0 (DE-576)372016677 |4 aut | |
| 700 | 1 | |a Ho, Anthony Dick |d 1948- |e VerfasserIn |0 (DE-588)108692477 |0 (DE-627)504904205 |0 (DE-576)19010466X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of molecular medicine |d Berlin : Springer, 1995 |g 90(2012), 7, Seite 773-782 |h Online-Ressource |w (DE-627)254630804 |w (DE-600)1462132-0 |w (DE-576)079420028 |x 1432-1440 |7 nnas |a Mesenchymal stromal cells (MSCs) science and f(r)iction |
| 773 | 1 | 8 | |g volume:90 |g year:2012 |g number:7 |g pages:773-782 |g extent:10 |a Mesenchymal stromal cells (MSCs) science and f(r)iction |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00109-012-0915-y |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://link.springer.com/article/10.1007/s00109-012-0915-y |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180625 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 108692477 |a Ho, Anthony Dick |m 108692477:Ho, Anthony Dick |d 910000 |d 910100 |e 910000PH108692477 |e 910100PH108692477 |k 0/910000/ |k 1/910000/910100/ |p 12 |y j | ||
| 998 | |g 1026722470 |a Klüter, Harald |m 1026722470:Klüter, Harald |d 60000 |d 63500 |d 60000 |e 60000PK1026722470 |e 63500PK1026722470 |e 60000PK1026722470 |k 0/60000/ |k 1/60000/63500/ |k 0/60000/ |p 10 | ||
| 998 | |g 123450284 |a Wuchter, Patrick |m 123450284:Wuchter, Patrick |d 910000 |d 910100 |e 910000PW123450284 |e 910100PW123450284 |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 998 | |g 124509991 |a Bieback, Karen |m 124509991:Bieback, Karen |d 60000 |d 63500 |d 60000 |e 60000PB124509991 |e 63500PB124509991 |e 60000PB124509991 |k 0/60000/ |k 1/60000/63500/ |k 0/60000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1576815757 |e 301367749X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"2012","dateIssuedKey":"2012"}],"note":["Published online: 31 May 2012","Gesehen am 25.06.2018"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title":"Mesenchymal stromal cells (MSCs)","title_sort":"Mesenchymal stromal cells (MSCs)","subtitle":"science and f(r)iction"}],"language":["eng"],"recId":"1576815757","name":{"displayForm":["Karen Bieback, Patrick Wuchter, Daniel Besser, Werner Franke, Matthias Becker, Michael Ott, Martin Pacher, Nan Ma, Christof Stamm, Harald Klüter, Albrecht Müller, Anthony D. Ho for the START-MSC consortium"]},"physDesc":[{"extent":"10 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"part":{"pages":"773-782","issue":"7","extent":"10","volume":"90","text":"90(2012), 7, Seite 773-782","year":"2012"},"disp":"Mesenchymal stromal cells (MSCs) science and f(r)ictionJournal of molecular medicine","pubHistory":["Volume 73, issue 1 (January 1995)-"],"title":[{"title_sort":"Journal of molecular medicine","title":"Journal of molecular medicine"}],"language":["eng"],"recId":"254630804","origin":[{"publisherPlace":"Berlin ; Heidelberg ; New York, NY","publisher":"Springer","dateIssuedKey":"1995","dateIssuedDisp":"1995-"}],"note":["Gesehen am 14.03.25"],"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"issn":["1432-1440"],"zdb":["1462132-0"],"eki":["254630804"]}}],"person":[{"role":"aut","roleDisplay":"VerfasserIn","given":"Karen","family":"Bieback","display":"Bieback, Karen"},{"display":"Wuchter, Patrick","family":"Wuchter","given":"Patrick","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Klüter, Harald","role":"aut","roleDisplay":"VerfasserIn","family":"Klüter","given":"Harald"},{"display":"Ho, Anthony Dick","roleDisplay":"VerfasserIn","role":"aut","family":"Ho","given":"Anthony Dick"}],"id":{"eki":["1576815757"],"doi":["10.1007/s00109-012-0915-y"]}} | ||
| SRT | |a BIEBACKKARMESENCHYMA2012 | ||