Integrins are required for tissue organization and restriction of neurogenesis in regenerating planarians
Skip to Next Section: Tissue regeneration depends on proliferative cells and on cues that regulate cell division, differentiation, patterning and the restriction of these processes once regeneration is complete. In planarians, flatworms with high regenerative potential, muscle cells express some of...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2017
|
| In: |
Development
Year: 2017, Jahrgang: 144, Heft: 5, Pages: 795-807 |
| ISSN: | 1477-9129 |
| DOI: | 10.1242/dev.139774 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1242/dev.139774 Verlag, kostenfrei, Volltext: http://dev.biologists.org/content/144/5/795 
|
| Verfasserangaben: | Florian Seebeck, Martin März, Anna-Wiebke Meyer, Hanna Reuter, Matthias C. Vogg, Martin Stehling, Karina Mildner, Dagmar Zeuschner, Franziska Rabert and Kerstin Bartscherer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1576823806 | ||
| 003 | DE-627 | ||
| 005 | 20220814173750.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180625s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1242/dev.139774 |2 doi | |
| 035 | |a (DE-627)1576823806 | ||
| 035 | |a (DE-576)506823806 | ||
| 035 | |a (DE-599)BSZ506823806 | ||
| 035 | |a (OCoLC)1341012809 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Seebeck, Florian |d 1985- |e VerfasserIn |0 (DE-588)1122488181 |0 (DE-627)875699782 |0 (DE-576)481342303 |4 aut | |
| 245 | 1 | 0 | |a Integrins are required for tissue organization and restriction of neurogenesis in regenerating planarians |c Florian Seebeck, Martin März, Anna-Wiebke Meyer, Hanna Reuter, Matthias C. Vogg, Martin Stehling, Karina Mildner, Dagmar Zeuschner, Franziska Rabert and Kerstin Bartscherer |
| 264 | 1 | |c 2017 | |
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published online February 28, 2017 | ||
| 500 | |a Gesehen am 25.06.2018 | ||
| 520 | |a Skip to Next Section: Tissue regeneration depends on proliferative cells and on cues that regulate cell division, differentiation, patterning and the restriction of these processes once regeneration is complete. In planarians, flatworms with high regenerative potential, muscle cells express some of these instructive cues. Here, we show that members of the integrin family of adhesion molecules are required for the integrity of regenerating tissues, including the musculature. Remarkably, in regenerating β1-integrin RNAi planarians, we detected increased numbers of mitotic cells and progenitor cell types, as well as a reduced ability of stem cells and lineage-restricted progenitor cells to accumulate at wound sites. These animals also formed ectopic spheroid structures of neural identity in regenerating heads. Interestingly, those polarized assemblies comprised a variety of neural cells and underwent continuous growth. Our study indicates that integrin-mediated cell adhesion is required for the regenerative formation of organized tissues and for restricting neurogenesis during planarian regeneration. | ||
| 700 | 1 | |a März, Martin |e VerfasserIn |0 (DE-588)1018476016 |0 (DE-627)682852570 |0 (DE-576)353922773 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Development |d Cambridge : The Company of Biologists, 1987 |g 144(2017), 5, Seite 795-807 |h Online-Ressource |w (DE-627)31982439X |w (DE-600)2007916-3 |w (DE-576)090893131 |x 1477-9129 |7 nnas |a Integrins are required for tissue organization and restriction of neurogenesis in regenerating planarians |
| 773 | 1 | 8 | |g volume:144 |g year:2017 |g number:5 |g pages:795-807 |g extent:13 |a Integrins are required for tissue organization and restriction of neurogenesis in regenerating planarians |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1242/dev.139774 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://dev.biologists.org/content/144/5/795 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180625 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 1018476016 |a März, Martin |m 1018476016:März, Martin |d 60000 |d 62300 |e 60000PM1018476016 |e 62300PM1018476016 |k 0/60000/ |k 1/60000/62300/ |p 2 | ||
| 999 | |a KXP-PPN1576823806 |e 3013705248 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.1242/dev.139774"],"eki":["1576823806"]},"origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"2017"}],"name":{"displayForm":["Florian Seebeck, Martin März, Anna-Wiebke Meyer, Hanna Reuter, Matthias C. Vogg, Martin Stehling, Karina Mildner, Dagmar Zeuschner, Franziska Rabert and Kerstin Bartscherer"]},"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1477-9129"],"eki":["31982439X"],"zdb":["2007916-3"]},"origin":[{"dateIssuedKey":"1987","publisher":"The Company of Biologists","dateIssuedDisp":"1987-","publisherPlace":"Cambridge"}],"name":{"displayForm":["Company of Biologists"]},"titleAlt":[{"title":"Development <Cambridge>"}],"part":{"extent":"13","text":"144(2017), 5, Seite 795-807","volume":"144","pages":"795-807","issue":"5","year":"2017"},"pubHistory":["Volume 99, 1 (January 1987)-"],"language":["eng"],"corporate":[{"display":"The Company of Biologists","roleDisplay":"Herausgebendes Organ","role":"isb"}],"recId":"31982439X","note":["Gesehen am 26.06.2025"],"disp":"Integrins are required for tissue organization and restriction of neurogenesis in regenerating planariansDevelopment","type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title":"Development","title_sort":"Development"}]}],"physDesc":[{"extent":"13 S."}],"title":[{"title_sort":"Integrins are required for tissue organization and restriction of neurogenesis in regenerating planarians","title":"Integrins are required for tissue organization and restriction of neurogenesis in regenerating planarians"}],"person":[{"role":"aut","display":"Seebeck, Florian","roleDisplay":"VerfasserIn","given":"Florian","family":"Seebeck"},{"given":"Martin","family":"März","role":"aut","display":"März, Martin","roleDisplay":"VerfasserIn"}],"recId":"1576823806","language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Published online February 28, 2017","Gesehen am 25.06.2018"]} | ||
| SRT | |a SEEBECKFLOINTEGRINSA2017 | ||