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Selective attenuation of electrophysiological activity of the dentate gyrus in a social defeat mouse model

Current research on stress pathology has revealed a set of molecular and cellular mechanisms through which psychosocial stress impairs brain function. However, there are few studies that have examined how chronic stress exposure alters neuronal activity patterns at a network level. Here, we recorded...

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Bibliographic Details
Main Authors: Aoki, Yuki (Author) , Hondrich, Timm (Author)
Format: Article (Journal)
Language:English
Published: 2017
In: The journal of physiological sciences
Year: 2016, Volume: 67, Issue: 4, Pages: 507-513
ISSN:1880-6562
DOI:10.1007/s12576-016-0481-0
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1007/s12576-016-0481-0
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Author Notes:Yuki Aoki, Yuya Nishimura, Timm Hondrich, Ryota Nakayama, Hideyoshi Igata, Takuya Sasaki, Yuji Ikegaya

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520 |a Current research on stress pathology has revealed a set of molecular and cellular mechanisms through which psychosocial stress impairs brain function. However, there are few studies that have examined how chronic stress exposure alters neuronal activity patterns at a network level. Here, we recorded ensemble neuronal activity patterns of the cortico-hippocampal network from urethane-anesthetized mice that were subjected to repeated social defeat stress. In socially defeated mice, the magnitudes of local field potential signals, including theta, slow gamma, and fast gamma oscillations, were significantly reduced in the dentate gyrus, whereas they remained unchanged in the hippocampus and somatosensory cortex. In accordance with the vast majority of histological and biochemical studies, our evidence from electrophysiological investigations highlights the dentate gyrus as a key brain area that is primarily susceptible to stress-induced dysfunction. 
534 |c 2016 
650 4 |a Aggression 
650 4 |a Animals 
650 4 |a Behavior, Animal 
650 4 |a Brain Waves 
650 4 |a Dentate gyrus 
650 4 |a Dentate Gyrus 
650 4 |a Disease Models, Animal 
650 4 |a Hippocampus 
650 4 |a Male 
650 4 |a Mice, Inbred C57BL 
650 4 |a Nerve Net 
650 4 |a Network 
650 4 |a Social Behavior 
650 4 |a Social stress 
650 4 |a Somatosensory Cortex 
650 4 |a Stress, Psychological 
650 4 |a Time Factors 
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