Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity
Electrophysiological and behavioral experiments in mice reveal that a cGMP-dependent kinase amplifies neurotransmitter release from peripheral pain sensors, potentiates spinal synapses, and leads to exaggerated pain.
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| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2012
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| In: |
PLoS biology
Year: 2012, Volume: 10, Issue: 3 |
| ISSN: | 1545-7885 |
| DOI: | 10.1371/journal.pbio.1001283 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1371/journal.pbio.1001283 Verlag, kostenfrei, Volltext: http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001283 
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| Author Notes: | Ceng Luo, Vijayan Gangadharan, Kiran Kumar Bali, Rou-Gang Xie, Nitin Agarwal, Martina Kurejova, Anke Tappe-Theodor, Irmgard Tegeder, Susanne Feil, Gary Lewin, Erika Polgar, Andrew J. Todd, Jens Schlossmann, Franz Hofmann, Da-Lu Liu, San-Jue Hu, Robert Feil, Thomas Kuner, Rohini Kuner |
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| 520 | |a Electrophysiological and behavioral experiments in mice reveal that a cGMP-dependent kinase amplifies neurotransmitter release from peripheral pain sensors, potentiates spinal synapses, and leads to exaggerated pain. | ||
| 650 | 4 | |a Behavioral conditioning | |
| 650 | 4 | |a Hyperalgesia | |
| 650 | 4 | |a Hypersensitivity | |
| 650 | 4 | |a Neurons | |
| 650 | 4 | |a Nociceptors | |
| 650 | 4 | |a Phosphorylation | |
| 650 | 4 | |a Spinal cord | |
| 650 | 4 | |a Synapses | |
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