Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity
Electrophysiological and behavioral experiments in mice reveal that a cGMP-dependent kinase amplifies neurotransmitter release from peripheral pain sensors, potentiates spinal synapses, and leads to exaggerated pain.
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2012
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| In: |
PLoS biology
Year: 2012, Jahrgang: 10, Heft: 3 |
| ISSN: | 1545-7885 |
| DOI: | 10.1371/journal.pbio.1001283 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1371/journal.pbio.1001283 Verlag, kostenfrei, Volltext: http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001283 |
| Verfasserangaben: | Ceng Luo, Vijayan Gangadharan, Kiran Kumar Bali, Rou-Gang Xie, Nitin Agarwal, Martina Kurejova, Anke Tappe-Theodor, Irmgard Tegeder, Susanne Feil, Gary Lewin, Erika Polgar, Andrew J. Todd, Jens Schlossmann, Franz Hofmann, Da-Lu Liu, San-Jue Hu, Robert Feil, Thomas Kuner, Rohini Kuner |
| Zusammenfassung: | Electrophysiological and behavioral experiments in mice reveal that a cGMP-dependent kinase amplifies neurotransmitter release from peripheral pain sensors, potentiates spinal synapses, and leads to exaggerated pain. |
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| Beschreibung: | Published March 13, 2012 Gesehen am 26.06.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1545-7885 |
| DOI: | 10.1371/journal.pbio.1001283 |