Blood oxygenation level-dependent (BOLD) MRI of human skeletal muscle at 1.5 and 3 T
Purpose: To evaluate the dependence of skeletal muscle blood oxygenation level-dependent (BOLD) effect and time course characteristics on magnetic field strength in healthy volunteers using an ischemia/reactive hyperemia paradigm. Materials and Methods: Two consecutive skeletal muscle BOLD magnetic...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2012
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| In: |
Journal of magnetic resonance imaging
Year: 2012, Volume: 35, Issue: 5, Pages: 1227-1232 |
| ISSN: | 1522-2586 |
| DOI: | 10.1002/jmri.23583 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1002/jmri.23583 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jmri.23583 
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| Author Notes: | Sasan Partovi, Anja-Carina Schulte, Bjoern Jacobi, Markus Klarhöfer, Alan B. Lumsden, Matthias Loebe, Mark G. Davies, Georg P. Noon, Christof Karmonik, Lisa Zipp, Georg Bongartz, and Deniz Bilecen |
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| 245 | 1 | 0 | |a Blood oxygenation level-dependent (BOLD) MRI of human skeletal muscle at 1.5 and 3 T |c Sasan Partovi, Anja-Carina Schulte, Bjoern Jacobi, Markus Klarhöfer, Alan B. Lumsden, Matthias Loebe, Mark G. Davies, Georg P. Noon, Christof Karmonik, Lisa Zipp, Georg Bongartz, and Deniz Bilecen |
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| 500 | |a First published: 13 January 2012 | ||
| 500 | |a Gesehen am 26.06.2018 | ||
| 520 | |a Purpose: To evaluate the dependence of skeletal muscle blood oxygenation level-dependent (BOLD) effect and time course characteristics on magnetic field strength in healthy volunteers using an ischemia/reactive hyperemia paradigm. Materials and Methods: Two consecutive skeletal muscle BOLD magnetic resonance imaging (MRI) measurements in eight healthy volunteers were performed on 1.5 T and 3.0 T whole-body MRI scanners. For both measurements a fat-saturated multi-shot multiecho gradient-echo EPI sequence was applied. Temporary vascular occlusion was induced by suprasystolic cuff compression of the thigh. T2* time courses were obtained from two different calf muscles and characterized by typical curve parameters. Ischemia- and hyperemia-induced changes in R2* (ΔR2*) were calculated for both muscles in each volunteer at the two field strengths. Results: Skeletal muscle BOLD changes are dependent on magnetic field strength as the ratio ΔR2*(3.0 T)/ΔR2*(1.5 T) was found to range between 1.6 and 2.2. Regarding time course characteristics, significantly higher relative T2* changes were found in both muscles at 3.0 T. Conclusion: The present study shows an approximately linear field strength dependence of ΔR2* in the skeletal muscle in response to ischemia and reactive hyperemia. Using higher magnetic fields is advisable for future BOLD imaging studies of peripheral limb pathologies. J. Magn. Reson. Imaging 2012;35:1227-1232. © 2012 Wiley Periodicals, Inc. | ||
| 650 | 4 | |a blood oxygenation level-dependent (BOLD) | |
| 650 | 4 | |a BOLD effect | |
| 650 | 4 | |a functional magnetic resonance imaging (fMRI) | |
| 650 | 4 | |a ischemia/reactive hyperemia paradigm | |
| 650 | 4 | |a magnetic field strength | |
| 650 | 4 | |a MRI | |
| 650 | 4 | |a skeletal muscle | |
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