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Hepcidin is regulated by promoter-associated histone acetylation and HDAC3

Hepcidin controls systemic iron levels by inhibiting intestinal iron absorption and iron recycling. Here, Pasricha et al. demonstrate that the hepcidin-chromatin locus displays HDAC3-mediated reversible epigenetic modifications during both erythropoiesis and iron deficiency.

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Bibliographic Details
Main Authors: Pasricha, Sant-Rayn (Author) , Mleczko-Sanecka, Katarzyna (Author) , Da Silva, Ana Rita (Author) , Muckenthaler, Martina (Author)
Format: Article (Journal)
Language:English
Published: 2017
In: Nature Communications
Year: 2017, Volume: 8, Issue: 1
ISSN:2041-1723
DOI:10.1038/s41467-017-00500-z
Online Access:Verlag, Volltext: http://dx.doi.org/10.1038/s41467-017-00500-z
Verlag, Volltext: https://www.nature.com/articles/s41467-017-00500-z
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Author Notes:Sant-Rayn Pasricha, Pei Jin Lim, Tiago L. Duarte, Carla Casu, Dorenda Oosterhuis, Katarzyna Mleczko-Sanecka, Maria Suciu, Ana Rita Da Silva, Kinda Al-Hourani, João Arezes, Kirsty McHugh, Sarah Gooding, Joe N. Frost, Katherine Wray, Ana Santos, Graça Porto, Emmanouela Repapi, Nicki Gray, Simon J. Draper, Neil Ashley, Elizabeth Soilleux, Peter Olinga, Martina U. Muckenthaler, Jim R. Hughes, Stefano Rivella, Thomas A. Milne, Andrew E. Armitage &Hal Drakesmith

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