Vitamin D status and epigenetic-based mortality risk score: strong independent and joint prediction of all-cause mortality in a population-based cohort study
Vitamin D deficiency and insufficiency have been established to be strongly associated with increased overall mortality and deaths from specific aging-related diseases. Recently, an epigenetic “mortality risk score” (MS) based on whole blood DNA methylation at the 10 most prominent mortality-related...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2018
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| In: |
Clinical epigenetics
Year: 2018, Jahrgang: 10 |
| ISSN: | 1868-7083 |
| DOI: | 10.1186/s13148-018-0515-y |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s13148-018-0515-y Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13148-018-0515-y 
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| Verfasserangaben: | Xu Gao, Yan Zhang, Ben Schöttker and Hermann Brenner |
| Zusammenfassung: | Vitamin D deficiency and insufficiency have been established to be strongly associated with increased overall mortality and deaths from specific aging-related diseases. Recently, an epigenetic “mortality risk score” (MS) based on whole blood DNA methylation at the 10 most prominent mortality-related cytosine-phosphate-guanine (CpG) sites has also been found to be highly related to all-cause mortality. This study aimed to explore whether vitamin D status, defined by serum 25-hydroxyvitamin D [25(OH)D] concentrations, is associated with the MS and to what extent both indicators are individually and jointly capable of predicting all-cause mortality in a general population sample of older adults. |
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| Beschreibung: | Published: 20 June 2018 Gesehen am 26.06.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1868-7083 |
| DOI: | 10.1186/s13148-018-0515-y |