Buchumschlag

Mathematical model of chimeric anti-gene receptor (CAR) T cell therapy with presence of cytokine

In this paper, we reconstruct a mathematical model of therapy by CAR T cells for acute lymphoblastic leukemia (ALL) With injection of modified T cells to body, then some signs such as fever, nausea and etc appear. These signs occur for the sake of cytokine release syndrome (CRS). This syndrome has a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Mostolizadeh, Reihaneh (VerfasserIn) , Afsharnezhad, Zahra (VerfasserIn) , Marciniak-Czochra, Anna (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2018
In: Numerical algebra, control and optimization
Year: 2018, Jahrgang: 8, Heft: 1, Pages: 63-80
ISSN:2155-3297
DOI:10.3934/naco.2018004
Online-Zugang:Resolving-System, Volltext: http://dx.doi.org/10.3934/naco.2018004
Volltext
Verfasserangaben:Reihaneh Mostolizadeh, Zahra Afsharnezhad, Anna Marciniak-Czochra

MARC

LEADER 00000caa a2200000 c 4500
001 1576927180
003 DE-627
005 20220814180152.0
007 cr uuu---uuuuu
008 180627s2018 xx |||||o 00| ||eng c
024 7 |a 10.3934/naco.2018004  |2 doi 
035 |a (DE-627)1576927180 
035 |a (DE-576)506927180 
035 |a (DE-599)BSZ506927180 
035 |a (OCoLC)1341012960 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 27  |2 sdnb 
100 1 |a Mostolizadeh, Reihaneh  |e VerfasserIn  |0 (DE-588)116183690X  |0 (DE-627)102529727X  |0 (DE-576)50692629X  |4 aut 
245 1 0 |a Mathematical model of chimeric anti-gene receptor (CAR) T cell therapy with presence of cytokine  |c Reihaneh Mostolizadeh, Zahra Afsharnezhad, Anna Marciniak-Czochra 
264 1 |c 2018 
300 |a 18 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 27.06.0218 
520 |a In this paper, we reconstruct a mathematical model of therapy by CAR T cells for acute lymphoblastic leukemia (ALL) With injection of modified T cells to body, then some signs such as fever, nausea and etc appear. These signs occur for the sake of cytokine release syndrome (CRS). This syndrome has a direct effect on result and satisfaction of therapy. So, the presence of cytokine will be played an important role in modelling process of therapy (CAR T cells). Therefore, the model will include the CAR T cells, B healthy and cancer cells, other circulating lymphocytes in blood, and cytokine. We analyse stability conditions of therapy Without any control, the dynamic model evidences sub-clinical or clinical decay, chronic destabilization, singularity immediately after a few hours and finally, it depends on the initial conditions. Hence, we try to show by which conditions, therapy will be effective. For this aim, we apply optimal control theory. 
700 1 |a Afsharnezhad, Zahra  |e VerfasserIn  |0 (DE-588)1161837191  |0 (DE-627)1025297830  |0 (DE-576)506926850  |4 aut 
700 1 |a Marciniak-Czochra, Anna  |d 1974-  |e VerfasserIn  |0 (DE-588)1044379626  |0 (DE-627)771928432  |0 (DE-576)397031505  |4 aut 
773 0 8 |i Enthalten in  |t Numerical algebra, control and optimization  |d Springfield, Mo. : AIMS, 2011  |g 8(2018), 1, Seite 63-80  |h Online-Ressource  |w (DE-627)722236735  |w (DE-600)2677552-9  |w (DE-576)432940308  |x 2155-3297  |7 nnas  |a Mathematical model of chimeric anti-gene receptor (CAR) T cell therapy with presence of cytokine 
773 1 8 |g volume:8  |g year:2018  |g number:1  |g pages:63-80  |g extent:18  |a Mathematical model of chimeric anti-gene receptor (CAR) T cell therapy with presence of cytokine 
856 4 0 |u http://dx.doi.org/10.3934/naco.2018004  |x Resolving-System  |x Verlag  |3 Volltext 
951 |a AR 
992 |a 20180627 
993 |a Article 
994 |a 2018 
998 |g 1044379626  |a Marciniak-Czochra, Anna  |m 1044379626:Marciniak-Czochra, Anna  |d 110000  |d 110200  |d 110000  |d 110400  |e 110000PM1044379626  |e 110200PM1044379626  |e 110000PM1044379626  |e 110400PM1044379626  |k 0/110000/  |k 1/110000/110200/  |k 0/110000/  |k 1/110000/110400/  |p 3  |y j 
999 |a KXP-PPN1576927180  |e 3014344060 
BIB |a Y 
SER |a journal 
JSO |a {"person":[{"family":"Mostolizadeh","display":"Mostolizadeh, Reihaneh","role":"aut","given":"Reihaneh"},{"role":"aut","given":"Zahra","display":"Afsharnezhad, Zahra","family":"Afsharnezhad"},{"display":"Marciniak-Czochra, Anna","family":"Marciniak-Czochra","role":"aut","given":"Anna"}],"origin":[{"dateIssuedDisp":"2018","dateIssuedKey":"2018"}],"note":["Gesehen am 27.06.0218"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title":"Mathematical model of chimeric anti-gene receptor (CAR) T cell therapy with presence of cytokine","title_sort":"Mathematical model of chimeric anti-gene receptor (CAR) T cell therapy with presence of cytokine"}],"language":["eng"],"name":{"displayForm":["Reihaneh Mostolizadeh, Zahra Afsharnezhad, Anna Marciniak-Czochra"]},"physDesc":[{"extent":"18 S."}],"recId":"1576927180","relHost":[{"corporate":[{"role":"isb","display":"American Institute of Mathematical Sciences"}],"disp":"Mathematical model of chimeric anti-gene receptor (CAR) T cell therapy with presence of cytokineNumerical algebra, control and optimization","note":["Gesehen am 08.07.24","Fortsetzung der Druck-Ausgabe"],"titleAlt":[{"title":"NACO"}],"origin":[{"publisherPlace":"Springfield, Mo.","dateIssuedDisp":"2011-","publisher":"AIMS","dateIssuedKey":"2011"}],"title":[{"subtitle":"(NACO)","title_sort":"Numerical algebra, control and optimization","title":"Numerical algebra, control and optimization"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"pages":"63-80","text":"8(2018), 1, Seite 63-80","year":"2018","volume":"8","extent":"18","issue":"1"},"language":["eng"],"name":{"displayForm":["American Institute of Mathematical Sciences"]},"physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["1.2011 -"],"recId":"722236735","id":{"zdb":["2677552-9"],"eki":["722236735"],"issn":["2155-3297"]}}],"id":{"eki":["1576927180"],"doi":["10.3934/naco.2018004"]}} 
SRT |a MOSTOLIZADMATHEMATIC2018 

Ähnliche Einträge