Nichtautonome Effekte des Onkogens YAP in der Hepatokarzinogenese
BackgroundThe transcriptional coactivator yes-associated protein (YAP) is a strong oncogene in liver cancer development.ObjectivesTo investigate if and how YAP-induced paracrine-acting factors are regulated in hepatocytes and liver cancer cells.Material and MethodsTranscriptome analysis and proteomi...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Deutsch |
| Veröffentlicht: |
2017
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| In: |
Der Pathologe
Year: 2017, Jahrgang: 38, Pages: 175-179 |
| ISSN: | 1432-1963 |
| DOI: | 10.1007/s00292-017-0361-2 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1007/s00292-017-0361-2 Verlag, Volltext: http://link.springer.com/article/10.1007/s00292-017-0361-2 
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| Verfasserangaben: | S. Marquard, S. Thomann, S. M. E. Weiler, C. Sticht, N. Gretz, P. Schirmacher, K. Breuhahn |
MARC
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| 520 | |a BackgroundThe transcriptional coactivator yes-associated protein (YAP) is a strong oncogene in liver cancer development.ObjectivesTo investigate if and how YAP-induced paracrine-acting factors are regulated in hepatocytes and liver cancer cells.Material and MethodsTranscriptome analysis and proteomics of murine wildtype and YAP-transgenic hepatocytes were performed to identify paracrine-acting proteins. Molecular and biochemical techniques were used to examine the mechanisms of YAP-dependent gene regulation. Gene expression data from HCC (hepatocellular carcinoma) patients was evaluated.ResultsSeveral YAP-dependent, secreted factors (e. g. CXCL10, GDF15, PDGFB) were identified. YAP regulates these factors through transcription factors of the TEAD (TEA domain) protein family. Moreover, the dysregulation of the YAP-target genes is often associated with poor HCC patient prognosis.ConclusionsYAP induces the expression of paracrine-acting factors that may affect the tumor microenvironment and therefore support carcinogenesis. This multicellular network could allow the development of novel and specific perturbation approaches. | ||
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