Potential relevance of shear stress for slit diaphragm and podocyte function
Filtrate flow through the glomerular barrier produces shear stresses that tend to disconnect podocytes from the glomerular basement membrane. Forces are highest within the filtration slits. The slit diaphragm mechanically balances the lateral components of the shear stresses on opposing foot process...
Gespeichert in:
| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2017
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| In: |
Kidney international
Year: 2017, Jahrgang: 91, Heft: 6, Pages: 1283-1286 |
| ISSN: | 1523-1755 |
| DOI: | 10.1016/j.kint.2017.02.032 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.kint.2017.02.032 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0085253817301746 
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| Verfasserangaben: | Wilhelm Kriz, Kevin V. Lemley |
| Zusammenfassung: | Filtrate flow through the glomerular barrier produces shear stresses that tend to disconnect podocytes from the glomerular basement membrane. Forces are highest within the filtration slits. The slit diaphragm mechanically balances the lateral components of the shear stresses on opposing foot processes, preventing widening of the slit. |
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| Beschreibung: | Available online 11 May 2017 Gesehen am 28.06.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1523-1755 |
| DOI: | 10.1016/j.kint.2017.02.032 |