Diabetes mellitus and bone metabolism
Diabetes mellitus and bone metabolism affect mesenchymal tissues and have numerous epidemiological and pathophysiological associations in common. Diabetes mellitus affects bone metabolism and increases fracture risk. The pathophysiological mechanims how type 1 and type 2 diabetes impair bone metabol...
Gespeichert in:
| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2017
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| In: |
Experimental and clinical endocrinology & diabetes
Year: 2017, Jahrgang: 125, Heft: 4, Pages: 213-217 |
| ISSN: | 1439-3646 |
| DOI: | 10.1055/s-0042-123036 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1055/s-0042-123036 Verlag, Volltext: https://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-123036 Verlag, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-123036 
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| Verfasserangaben: | Christian Kasperk, Carmen Georgescu, Peter Nawroth |
| Zusammenfassung: | Diabetes mellitus and bone metabolism affect mesenchymal tissues and have numerous epidemiological and pathophysiological associations in common. Diabetes mellitus affects bone metabolism and increases fracture risk. The pathophysiological mechanims how type 1 and type 2 diabetes impair bone metabolism and bone strength may differ which is outlined in this review. Direct metabolic effects in additon to centrally controlled endocrine loops exert suppressive effects on bone formation and may also stimulate bone Resorption. Decreased bone formation in combination with increased bone resorption strongly increases fracture risk.</p> |
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| Beschreibung: | Publikationsdatum: 10.Januar 2017 (eFirst) Gesehen am 02.07.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1439-3646 |
| DOI: | 10.1055/s-0042-123036 |