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Diabetes mellitus and bone metabolism

Diabetes mellitus and bone metabolism affect mesenchymal tissues and have numerous epidemiological and pathophysiological associations in common. Diabetes mellitus affects bone metabolism and increases fracture risk. The pathophysiological mechanims how type 1 and type 2 diabetes impair bone metabol...

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Main Authors: Kasperk, Christian (Author) , Georgescu, Carmen (Author) , Nawroth, Peter Paul (Author)
Format: Article (Journal)
Language:English
Published: 2017
In: Experimental and clinical endocrinology & diabetes
Year: 2017, Volume: 125, Issue: 4, Pages: 213-217
ISSN:1439-3646
DOI:10.1055/s-0042-123036
Online Access:Verlag, Volltext: http://dx.doi.org/10.1055/s-0042-123036
Verlag, Volltext: https://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-123036
Verlag, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-123036
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Author Notes:Christian Kasperk, Carmen Georgescu, Peter Nawroth

MARC

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520 |a Diabetes mellitus and bone metabolism affect mesenchymal tissues and have numerous epidemiological and pathophysiological associations in common. Diabetes mellitus affects bone metabolism and increases fracture risk. The pathophysiological mechanims how type 1 and type 2 diabetes impair bone metabolism and bone strength may differ which is outlined in this review. Direct metabolic effects in additon to centrally controlled endocrine loops exert suppressive effects on bone formation and may also stimulate bone Resorption. Decreased bone formation in combination with increased bone resorption strongly increases fracture risk.</p> 
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