Azole-resistant invasive aspergillosis in a patient with acute myeloid leukaemia in Germany
We report the first culture-proven case of invasive aspergillosis (IA) caused by azole-resistant Aspergillus fumigatus in a patient with acute myeloid leukaemia in Germany. IA presented as breakthrough infection under posaconazole prophylaxis. Analysis of the resistance mechanism revealed the TR/L98...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
6 September 2012
|
| In: |
Eurosurveillance
Year: 2012, Volume: 17, Issue: 36 |
| ISSN: | 1560-7917 |
| DOI: | 10.2807/ese.17.36.20262-en |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.2807/ese.17.36.20262-en Verlag, kostenfrei, Volltext: https://www.eurosurveillance.org/content/10.2807/ese.17.36.20262-en 
|
| Author Notes: | A Hamprecht, D Buchheidt, JJ Vehreschild, OA Cornely, B Spiess, G Plum, TV Halbsguth, N Kutsch, D Stippel, P Kahl, T Persigehl, A Steinbach, B Bos, M Hallek, MJ Vehreschild |
| Summary: | We report the first culture-proven case of invasive aspergillosis (IA) caused by azole-resistant Aspergillus fumigatus in a patient with acute myeloid leukaemia in Germany. IA presented as breakthrough infection under posaconazole prophylaxis. Analysis of the resistance mechanism revealed the TR/L98H mutation in the cyp51A gene, which indicates an environmental origin of the strain. This case underscores the need for monitoring azole resistance in Aspergillus spp. and for routine susceptibility testing of moulds. |
|---|---|
| Item Description: | Gesehen am 02.07.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1560-7917 |
| DOI: | 10.2807/ese.17.36.20262-en |