Omega-6 fatty acids: opposing associations with risk : the Ludwigshafen Risk and Cardiovascular Health Study
Background: Omega-6 polyunsaturated fatty acids (omega-6 PUFA) are recommended in European cardiovascular prevention guidelines. However, individual fatty acids have distinct biological functions, and there have been conflicting reports about the association of omega-6 PUFA with cardiovascular risk....
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2017
|
| In: |
Journal of clinical lipidology
Year: 2017, Jahrgang: 11, Heft: 4, Pages: 1082-1090.e14 |
| ISSN: | 1876-4789 |
| DOI: | 10.1016/j.jacl.2017.05.003 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.jacl.2017.05.003 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S193328741730329X 
|
| Verfasserangaben: | Graciela E. Delgado, MSc, Winfried März, MD, Stefan Lorkowski, PhD, Clemens von Schacky, MD, Marcus E. Kleber, PhD |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1577188365 | ||
| 003 | DE-627 | ||
| 005 | 20240316100448.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180702s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jacl.2017.05.003 |2 doi | |
| 035 | |a (DE-627)1577188365 | ||
| 035 | |a (DE-576)507188365 | ||
| 035 | |a (DE-599)BSZ507188365 | ||
| 035 | |a (OCoLC)1341013217 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Delgado Gonzales de Kleber, Graciela |d 1960- |e VerfasserIn |0 (DE-588)1070236403 |0 (DE-627)823400379 |0 (DE-576)429882386 |4 aut | |
| 245 | 1 | 0 | |a Omega-6 fatty acids |b opposing associations with risk : the Ludwigshafen Risk and Cardiovascular Health Study |c Graciela E. Delgado, MSc, Winfried März, MD, Stefan Lorkowski, PhD, Clemens von Schacky, MD, Marcus E. Kleber, PhD |
| 264 | 1 | |c 2017 | |
| 300 | |a 23 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online 1 June 2017 | ||
| 500 | |a Gesehen am 02.07.2018 | ||
| 520 | |a Background: Omega-6 polyunsaturated fatty acids (omega-6 PUFA) are recommended in European cardiovascular prevention guidelines. However, individual fatty acids have distinct biological functions, and there have been conflicting reports about the association of omega-6 PUFA with cardiovascular risk. Objective: The aim of our study was to investigate the association of individual omega-6 fatty acids with mortality in a cohort of patients referred for coronary angiography. Methods: Omega-6 PUFA proportions were measured in erythrocytes at baseline in a total of 3259 patients participating in the Ludwigshafen Risk and Cardiovascular Health Study using the HS-Omega-3 Index method. Associations of omega-6 PUFA with mortality were analyzed by Cox regression with adjustment for conventional risk factors. Results: During a median follow-up of 10.0 years, 975 patients (29.9%) died, 614 patients (18.8%) from cardiovascular causes. γ-Linolenic acid was inversely associated with all-cause and cardiovascular mortalities in models adjusted for cardiovascular risk factors with hazard ratios of 0.88 (0.82-0.95) and 0.86 (0.79-0.95) per 1-standard deviation increase, respectively. Adrenic acid and docosapentaenoic acid ω-6 were both directly associated with risk with hazard ratio of 1.10 (1.30-1.18) and 1.12 (1.05-1.19) for all-cause mortality, respectively. No association was found for arachidonic acid. Conclusions: We observed opposing associations of individual omega-6 PUFA with mortality risk. While LA and γ-linolenic acid were associated with reduced risk, there was a direct association for adrenic acid and docosapentaenoic acid. These differences do not support the use of omega-6 PUFA concentrations as a single combined metric, and the prognostic value of each individual member should be examined separately. | ||
| 650 | 4 | |a Risk factors | |
| 650 | 4 | |a Arachidonic acid | |
| 650 | 4 | |a Linoleic acid | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Nutrition | |
| 650 | 4 | |a Omega-6 fatty acids | |
| 700 | 1 | |a März, Winfried |d 1958- |e VerfasserIn |0 (DE-588)1027603599 |0 (DE-627)729463605 |0 (DE-576)373454635 |4 aut | |
| 700 | 1 | |a Kleber, Marcus E. |d 1974- |e VerfasserIn |0 (DE-588)1030135177 |0 (DE-627)734830440 |0 (DE-576)377941379 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of clinical lipidology |d Amsterdam [u.a.] : Elsevier, 2007 |g 11(2017), 4, Seite 1082-1090.e14 |h Online-Ressource |w (DE-627)534059252 |w (DE-600)2365061-8 |w (DE-576)284926973 |x 1876-4789 |7 nnas |a Omega-6 fatty acids opposing associations with risk : the Ludwigshafen Risk and Cardiovascular Health Study |
| 773 | 1 | 8 | |g volume:11 |g year:2017 |g number:4 |g pages:1082-1090.e14 |g extent:23 |a Omega-6 fatty acids opposing associations with risk : the Ludwigshafen Risk and Cardiovascular Health Study |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.jacl.2017.05.003 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S193328741730329X |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180702 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 1030135177 |a Kleber, Marcus E. |m 1030135177:Kleber, Marcus E. |d 60000 |d 61400 |e 60000PK1030135177 |e 61400PK1030135177 |k 0/60000/ |k 1/60000/61400/ |p 5 |y j | ||
| 998 | |g 1027603599 |a März, Winfried |m 1027603599:März, Winfried |d 60000 |d 61400 |e 60000PM1027603599 |e 61400PM1027603599 |k 0/60000/ |k 1/60000/61400/ |p 2 | ||
| 998 | |g 1070236403 |a Delgado Gonzales de Kleber, Graciela |m 1070236403:Delgado Gonzales de Kleber, Graciela |d 60000 |d 61400 |e 60000PD1070236403 |e 61400PD1070236403 |k 0/60000/ |k 1/60000/61400/ |p 1 |x j | ||
| 999 | |a KXP-PPN1577188365 |e 3015526448 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"2017","dateIssuedKey":"2017"}],"note":["Available online 1 June 2017","Gesehen am 02.07.2018"],"recId":"1577188365","name":{"displayForm":["Graciela E. Delgado, MSc, Winfried März, MD, Stefan Lorkowski, PhD, Clemens von Schacky, MD, Marcus E. Kleber, PhD"]},"relHost":[{"language":["eng"],"title":[{"subtitle":"official journal of the National Lipid Association","title":"Journal of clinical lipidology","title_sort":"Journal of clinical lipidology"}],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Omega-6 fatty acids opposing associations with risk : the Ludwigshafen Risk and Cardiovascular Health StudyJournal of clinical lipidology","note":["Gesehen am 15.06.07"],"pubHistory":["1.2007 -"],"part":{"text":"11(2017), 4, Seite 1082-1090.e14","issue":"4","pages":"1082-1090.e14","year":"2017","extent":"23","volume":"11"},"id":{"zdb":["2365061-8"],"issn":["1876-4789"],"eki":["534059252"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"534059252","origin":[{"publisher":"Elsevier","dateIssuedDisp":"2007-","dateIssuedKey":"2007","publisherPlace":"Amsterdam [u.a.]"}]}],"title":[{"title":"Omega-6 fatty acids","subtitle":"opposing associations with risk : the Ludwigshafen Risk and Cardiovascular Health Study","title_sort":"Omega-6 fatty acids"}],"id":{"eki":["1577188365"],"doi":["10.1016/j.jacl.2017.05.003"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"23 S."}],"language":["eng"],"person":[{"given":"Graciela","family":"Delgado Gonzales de Kleber","role":"aut","display":"Delgado Gonzales de Kleber, Graciela"},{"display":"März, Winfried","role":"aut","family":"März","given":"Winfried"},{"role":"aut","display":"Kleber, Marcus E.","given":"Marcus E.","family":"Kleber"}]} | ||
| SRT | |a DELGADOGONOMEGA6FATT2017 | ||