Dorsal root ganglia hypertrophy as in vivo correlate of oxaliplatin-induced polyneuropathy
PURPOSE: To investigate in vivo morphological and functional correlates of oxaliplatin-induced peripheral neuropathy (OXA-PNP) by magnetic resonance neurography (MRN). METHODS: Twenty patients (7 female, 13 male, 58.9±10.0 years) with mild to moderate OXA-PNP and 20 matched controls (8 female, 12 ma...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
August 24, 2017
|
| In: |
PLOS ONE
Year: 2017, Volume: 12, Issue: 8 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0183845 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1371/journal.pone.0183845
|
| Author Notes: | Leonidas Apostolidis, Daniel Schwarz, Annie Xia, Markus Weiler, Andreas Heckel, Tim Godel, Sabine Heiland, Heinz-Peter Schlemmer, Dirk Jäger, Martin Bendszus, Philipp Bäumer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1577220161 | ||
| 003 | DE-627 | ||
| 005 | 20220814182643.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180703s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1371/journal.pone.0183845 |2 doi | |
| 035 | |a (DE-627)1577220161 | ||
| 035 | |a (DE-576)507220161 | ||
| 035 | |a (DE-599)BSZ507220161 | ||
| 035 | |a (OCoLC)1341013299 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Apostolidis, Leonidas |d 1981- |e VerfasserIn |0 (DE-588)139136932 |0 (DE-627)703220594 |0 (DE-576)309798590 |4 aut | |
| 245 | 1 | 0 | |a Dorsal root ganglia hypertrophy as in vivo correlate of oxaliplatin-induced polyneuropathy |c Leonidas Apostolidis, Daniel Schwarz, Annie Xia, Markus Weiler, Andreas Heckel, Tim Godel, Sabine Heiland, Heinz-Peter Schlemmer, Dirk Jäger, Martin Bendszus, Philipp Bäumer |
| 264 | 1 | |c August 24, 2017 | |
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 03.07.2018 | ||
| 520 | |a PURPOSE: To investigate in vivo morphological and functional correlates of oxaliplatin-induced peripheral neuropathy (OXA-PNP) by magnetic resonance neurography (MRN). METHODS: Twenty patients (7 female, 13 male, 58.9±10.0 years) with mild to moderate OXA-PNP and 20 matched controls (8 female, 12 male, 55.7±15.6 years) were prospectively enrolled. All patients underwent a detailed neurophysiological examination prior to neuroimaging. A standardized imaging protocol at 3.0 Tesla included the lumbosacral plexus and both sciatic nerves and their branches using T2-weighted fat-saturated sequences and diffusion tensor imaging. Quantitative assessment included volumetry of the dorsal root ganglia (DRG), sciatic nerve normalized T2 (nT2) signal and caliber, and fractional anisotropy (FA), mean diffusivity (MD), axial (AD) and radial diffusivity (RD). Additional qualitative evaluation of sciatic, peroneal, and tibial nerves evaluated the presence, degree, and distribution of nerve lesions. RESULTS: DRG hypertrophy in OXA-PNP patients (207.3±47.7mm3 vs. 153.0±47.1mm3 in controls, p = 0.001) was found as significant morphological correlate of the sensory neuronopathy. In contrast, peripheral nerves only exhibited minor morphological alterations qualitatively. Quantitatively, sciatic nerve caliber (27.3±6.7mm2 vs. 27.4±7.4mm2, p = 0.80) and nT2 signal were not significantly changed in patients (1.32±0.22 vs. 1.22±0.26, p = 0.16). AD, RD, and MD showed a non-significant decrease in patients, while FA was unchanged. CONCLUSION: OXA-PNP manifests with morphological and functional correlates that can be detected in vivo by MRN. We report hypertrophy of the DRG that stands in contrast to experimental and postmortem studies. DRG volume should be further investigated as a biomarker in other sensory peripheral neuropathies and ganglionopathies. | ||
| 650 | 4 | |a Aged | |
| 650 | 4 | |a Diffusion Tensor Imaging | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Ganglia, Spinal | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Magnetic Resonance Imaging | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a Organoplatinum Compounds | |
| 650 | 4 | |a Polyneuropathies | |
| 700 | 1 | |a Schwarz, Daniel |d 1983- |e VerfasserIn |0 (DE-588)1104866781 |0 (DE-627)862224926 |0 (DE-576)472943065 |4 aut | |
| 700 | 1 | |a Xia, Annie |d 1990- |e VerfasserIn |0 (DE-588)1153849623 |0 (DE-627)1015401708 |0 (DE-576)500603693 |4 aut | |
| 700 | 1 | |a Weiler, Markus |d 1972- |e VerfasserIn |0 (DE-588)123920256 |0 (DE-627)706474236 |0 (DE-576)293943079 |4 aut | |
| 700 | 1 | |a Heckel, Andreas |d 1978- |e VerfasserIn |0 (DE-588)141015535 |0 (DE-627)623823683 |0 (DE-576)321788192 |4 aut | |
| 700 | 1 | |a Godel, Tim |d 1985- |e VerfasserIn |0 (DE-588)1153513471 |0 (DE-627)1014950384 |0 (DE-576)500281394 |4 aut | |
| 700 | 1 | |a Heiland, Sabine |e VerfasserIn |0 (DE-588)106732626X |0 (DE-627)818624450 |0 (DE-576)426561368 |4 aut | |
| 700 | 1 | |a Jäger, Dirk |d 1964- |e VerfasserIn |0 (DE-588)1032507535 |0 (DE-627)738505323 |0 (DE-576)380074125 |4 aut | |
| 700 | 1 | |a Bendszus, Martin |e VerfasserIn |0 (DE-588)1032676426 |0 (DE-627)738634131 |0 (DE-576)175567697 |4 aut | |
| 700 | 1 | |a Bäumer, Philipp |d 1981- |e VerfasserIn |0 (DE-588)138369836 |0 (DE-627)696555735 |0 (DE-576)307128032 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t PLOS ONE |d San Francisco, California, US : PLOS, 2006 |g 12(2017,8) Artikel-Nummer e0183845, 15 Seiten |h Online-Ressource |w (DE-627)523574592 |w (DE-600)2267670-3 |w (DE-576)281331979 |x 1932-6203 |7 nnas |a Dorsal root ganglia hypertrophy as in vivo correlate of oxaliplatin-induced polyneuropathy |
| 773 | 1 | 8 | |g volume:12 |g year:2017 |g number:8 |g extent:15 |a Dorsal root ganglia hypertrophy as in vivo correlate of oxaliplatin-induced polyneuropathy |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1371/journal.pone.0183845 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180703 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 138369836 |a Bäumer, Philipp |m 138369836:Bäumer, Philipp |d 50000 |e 50000PB138369836 |k 0/50000/ |p 11 |y j | ||
| 998 | |g 1032676426 |a Bendszus, Martin |m 1032676426:Bendszus, Martin |d 910000 |d 911100 |e 910000PB1032676426 |e 911100PB1032676426 |k 0/910000/ |k 1/910000/911100/ |p 10 | ||
| 998 | |g 1032507535 |a Jäger, Dirk |m 1032507535:Jäger, Dirk |d 910000 |e 910000PJ1032507535 |k 0/910000/ |p 9 | ||
| 998 | |g 106732626X |a Heiland, Sabine |m 106732626X:Heiland, Sabine |d 910000 |d 911100 |e 910000PH106732626X |e 911100PH106732626X |k 0/910000/ |k 1/910000/911100/ |p 7 | ||
| 998 | |g 1153513471 |a Godel, Tim |m 1153513471:Godel, Tim |d 910000 |d 911100 |e 910000PG1153513471 |e 911100PG1153513471 |k 0/910000/ |k 1/910000/911100/ |p 6 | ||
| 998 | |g 141015535 |a Heckel, Andreas |m 141015535:Heckel, Andreas |d 910000 |d 911100 |e 910000PH141015535 |e 911100PH141015535 |k 0/910000/ |k 1/910000/911100/ |p 5 | ||
| 998 | |g 123920256 |a Weiler, Markus |m 123920256:Weiler, Markus |d 910000 |d 911100 |e 910000PW123920256 |e 911100PW123920256 |k 0/910000/ |k 1/910000/911100/ |p 4 | ||
| 998 | |g 1153849623 |a Xia, Annie |m 1153849623:Xia, Annie |d 910000 |d 911100 |e 910000PX1153849623 |e 911100PX1153849623 |k 0/910000/ |k 1/910000/911100/ |p 3 | ||
| 998 | |g 1104866781 |a Schwarz, Daniel |m 1104866781:Schwarz, Daniel |d 910000 |d 911100 |e 910000PS1104866781 |e 911100PS1104866781 |k 0/910000/ |k 1/910000/911100/ |p 2 | ||
| 998 | |g 139136932 |a Apostolidis, Leonidas |m 139136932:Apostolidis, Leonidas |d 910000 |e 910000PA139136932 |k 0/910000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1577220161 |e 3015902962 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"Dorsal root ganglia hypertrophy as in vivo correlate of oxaliplatin-induced polyneuropathy","title":"Dorsal root ganglia hypertrophy as in vivo correlate of oxaliplatin-induced polyneuropathy"}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedDisp":"August 24, 2017","dateIssuedKey":"2017"}],"recId":"1577220161","physDesc":[{"extent":"15 S."}],"id":{"doi":["10.1371/journal.pone.0183845"],"eki":["1577220161"]},"note":["Gesehen am 03.07.2018"],"relHost":[{"title":[{"title":"PLOS ONE","title_sort":"PLOS ONE"}],"language":["eng"],"part":{"extent":"15","text":"12(2017,8) Artikel-Nummer e0183845, 15 Seiten","year":"2017","volume":"12","issue":"8"},"pubHistory":["1.2006 -"],"name":{"displayForm":["Public Library of Science"]},"disp":"Dorsal root ganglia hypertrophy as in vivo correlate of oxaliplatin-induced polyneuropathyPLOS ONE","physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["523574592"],"zdb":["2267670-3"],"issn":["1932-6203"]},"corporate":[{"display":"Public Library of Science","role":"isb"}],"note":["Schreibweise des Titels bis 2012: PLoS ONE","Gesehen am 20.03.19"],"origin":[{"publisherPlace":"San Francisco, California, US ; Lawrence, Kan.","dateIssuedKey":"2006","dateIssuedDisp":"2006-","publisher":"PLOS ; PLoS"}],"recId":"523574592","type":{"media":"Online-Ressource","bibl":"periodical"}}],"name":{"displayForm":["Leonidas Apostolidis, Daniel Schwarz, Annie Xia, Markus Weiler, Andreas Heckel, Tim Godel, Sabine Heiland, Heinz-Peter Schlemmer, Dirk Jäger, Martin Bendszus, Philipp Bäumer"]},"person":[{"family":"Apostolidis","given":"Leonidas","role":"aut","display":"Apostolidis, Leonidas"},{"family":"Schwarz","role":"aut","given":"Daniel","display":"Schwarz, Daniel"},{"display":"Xia, Annie","role":"aut","given":"Annie","family":"Xia"},{"family":"Weiler","given":"Markus","role":"aut","display":"Weiler, Markus"},{"family":"Heckel","role":"aut","given":"Andreas","display":"Heckel, Andreas"},{"role":"aut","given":"Tim","display":"Godel, Tim","family":"Godel"},{"family":"Heiland","role":"aut","given":"Sabine","display":"Heiland, Sabine"},{"display":"Jäger, Dirk","given":"Dirk","role":"aut","family":"Jäger"},{"role":"aut","given":"Martin","display":"Bendszus, Martin","family":"Bendszus"},{"family":"Bäumer","given":"Philipp","role":"aut","display":"Bäumer, Philipp"}]} | ||
| SRT | |a APOSTOLIDIDORSALROOT2420 | ||