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Tumor-platelet interaction in solid tumors

Elevated platelet counts in patients diagnosed with malignant tumors were first described more than 100 years ago. Today it is well known that in many types of solid tumors, thrombocytosis at the time of diagnosis is associated with shorter survival. From this well-documented clinical correlation be...

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Bibliographic Details
Main Authors: Bürgy, Daniel (Author) , Wenz, Frederik (Author) , Groden, Christoph (Author) , Brockmann, Marc Alexander (Author)
Format: Article (Journal)
Language:English
Published: 19 January 2012
In: International journal of cancer
Year: 2012, Volume: 130, Issue: 12, Pages: 2747-2760
ISSN:1097-0215
DOI:10.1002/ijc.27441
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1002/ijc.27441
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.27441
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Author Notes:Daniel Buergy, Frederik Wenz, Christoph Groden and Marc A. Brockmann

MARC

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520 |a Elevated platelet counts in patients diagnosed with malignant tumors were first described more than 100 years ago. Today it is well known that in many types of solid tumors, thrombocytosis at the time of diagnosis is associated with shorter survival. From this well-documented clinical correlation between platelet count and prognosis of solid tumors, the following questions arise: (i) Are the increased platelet counts the reason for shortened survival as platelet-secreted cytokines might boost tumor growth and angiogenesis? (ii) Do platelets affect tumor metastasis thereby shortening survival time? or (iii) Are increased platelet counts simply an epiphenomenon of tumor growth with larger tumors resulting in higher platelet counts and shorter survival times? We address these three questions within our review of the current literature to provide a comprehensive overview of the current concepts in tumor-platelet interaction. 
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