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The influence of surgical technique on early posttransplant atrial fibrillation: comparison of biatrial, bicaval, and total orthotopic heart transplantation

Purpose Early posttransplant atrial fibrillation (AF) has been associated with worse clinical outcomes after heart transplantation (HTX). The type of surgical technique may constitute a relevant risk factor for AF. Patients and methods This retrospective single-center study included 530 adult patien...

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Hauptverfasser: Rivinius, Rasmus (VerfasserIn) , Helmschrott, Matthias (VerfasserIn) , Ruhparwar, Arjang (VerfasserIn) , Erbel, Christian (VerfasserIn) , Gleißner, Christian A. (VerfasserIn) , Darche, Fabrice Fernand (VerfasserIn) , Thomas, Dierk (VerfasserIn) , Bruckner, Thomas (VerfasserIn) , Katus, Hugo (VerfasserIn) , Dösch, Andreas (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 8 March 2017
In: Therapeutics and clinical risk management
Year: 2017, Jahrgang: 13, Pages: 287-297
ISSN:1178-203X
DOI:10.2147/TCRM.S126869
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.2147/TCRM.S126869
Verlag, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352240/
Volltext
Verfasserangaben:Rasmus Rivinius, Matthias Helmschrott, Arjang Ruhparwar, Christian Erbel, Christian A Gleissner, Fabrice F Darche, Dierk Thomas, Tom Bruckner, Hugo A Katus, Andreas O Doesch
Beschreibung
Zusammenfassung:Purpose Early posttransplant atrial fibrillation (AF) has been associated with worse clinical outcomes after heart transplantation (HTX). The type of surgical technique may constitute a relevant risk factor for AF. Patients and methods This retrospective single-center study included 530 adult patients. Patients were stratified by surgical technique (biatrial, bicaval, or total orthotopic HTX) and early posttransplant heart rhythm (AF or sinus rhythm). Univariate and multivariate analyses were performed to evaluate risk factors for AF. Results A total of 161 patients received biatrial HTX (30.4%), 115 bicaval HTX (21.7%), and 254 total orthotopic HTX (47.9%). Sixty-one of 530 patients developed early posttransplant AF (11.5%). Patients with AF showed a statistically inferior 5-year survival compared to those with sinus rhythm (P<0.0001). Total orthotopic HTX had the lowest rate of AF (total orthotopic HTX [6.3%], bicaval HTX [14.8%], biatrial HTX [17.4%], P=0.0012). Multivariate analysis showed pretransplant valvular heart disease (P=0.0372), posttransplant enlarged left atrium (P=0.0066), posttransplant mitral regurgitation (P=0.0370), and non-total orthotopic HTX (P=0.0112) as risk factors for AF. Conclusion Early posttransplant AF was associated with increased mortality (P<0.0001). Total orthotopic HTX showed the lowest rate of AF compared to biatrial or bicaval HTX (P=0.0012).
Beschreibung:Gesehen am 04.07.2018
Beschreibung:Online Resource
ISSN:1178-203X
DOI:10.2147/TCRM.S126869

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