Buchumschlag

Impact of spontaneous donor hypothermia on graft outcomes after kidney transplantation

A previous donor intervention trial found that therapeutic hypothermia reduced delayed graft function (DGF) after kidney transplantation. This retrospective cohort study nested in the randomized dopamine trial (ClinicalTrials.gov identifier: NCT000115115) investigates the effects of spontaneous dono...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Schnülle, Peter (VerfasserIn) , Mundt, Heiko (VerfasserIn) , Drüschler, Felix (VerfasserIn) , Schmitt, Wilhelm (VerfasserIn) , Yard, Benito A. (VerfasserIn) , Krämer, Bernhard (VerfasserIn) , Benck, Urs Tobias (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2018
In: American journal of transplantation
Year: 2017, Jahrgang: 18, Heft: 3, Pages: 704-714
ISSN:1600-6143
DOI:10.1111/ajt.14541
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1111/ajt.14541
Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/ajt.14541
Volltext
Verfasserangaben:P. Schnuelle, H.M. Mundt, F. Drüschler, W.H. Schmitt, B.A. Yard, B.K. Krämer, U. Benck

MARC

LEADER 00000caa a2200000 c 4500
001 1577261461
003 DE-627
005 20220814183320.0
007 cr uuu---uuuuu
008 180704r20182017xx |||||o 00| ||eng c
024 7 |a 10.1111/ajt.14541  |2 doi 
035 |a (DE-627)1577261461 
035 |a (DE-576)507261461 
035 |a (DE-599)BSZ507261461 
035 |a (OCoLC)1341013206 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Schnülle, Peter  |d 1957-  |e VerfasserIn  |0 (DE-588)1028873905  |0 (DE-627)731785282  |0 (DE-576)376314907  |4 aut 
245 1 0 |a Impact of spontaneous donor hypothermia on graft outcomes after kidney transplantation  |c P. Schnuelle, H.M. Mundt, F. Drüschler, W.H. Schmitt, B.A. Yard, B.K. Krämer, U. Benck 
264 1 |c 2018 
300 |a 11 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 04.07.2018 
520 |a A previous donor intervention trial found that therapeutic hypothermia reduced delayed graft function (DGF) after kidney transplantation. This retrospective cohort study nested in the randomized dopamine trial (ClinicalTrials.gov identifier: NCT000115115) investigates the effects of spontaneous donor hypothermia (core body temperature <36°C) on initial kidney graft function, and evaluates 5-year graft survival. Hypothermia assessed by a singular measurement in the intensive care unit 4-20 hours before procurement was associated with less DGF after kidney transplantation (odds ratio [OR] 0.56, 95% confidence interval [CI] 0.34-0.91). The benefit was greater when need for more than a single posttransplant dialysis session was analyzed (OR 0.48, 95%CI 0.28-0.82). Donor dopamine ameliorated dialysis requirement independently from hypothermia in a temporal relationship with exposure (OR 0.93, 95%CI 0.87-0.98, per hour). A lower core body temperature in the donor was associated with lower serum creatinine levels before procurement, which may reflect lower systemic inflammation and attenuated renal injury from brain death. Despite a considerable effect on DGF, our study failed to demonstrate a graft survival advantage (hazard ratio [HR] 0.83, 95%CI 0.54-1.27), whereas dopamine treatment was associated with improved long-term outcome (HR 0.95, 95%CI 0.91-0.99 per hour). 
534 |c 2017 
650 4 |a clinical research/practice 
650 4 |a delayed graft function (DGF) 
650 4 |a donors and donation: donation after brain death (DBD) 
650 4 |a graft survival 
650 4 |a kidney (allograft) function/dysfunction 
650 4 |a kidney transplantation/nephrology 
650 4 |a organ procurement 
650 4 |a organ procurement and allocation 
700 1 |a Mundt, Heiko  |d 1982-  |e VerfasserIn  |0 (DE-588)1025476972  |0 (DE-627)722370571  |0 (DE-576)370386884  |4 aut 
700 1 |a Drüschler, Felix  |e VerfasserIn  |0 (DE-588)1162207027  |0 (DE-627)1025676955  |0 (DE-576)507262506  |4 aut 
700 1 |a Schmitt, Wilhelm  |d 1960-  |e VerfasserIn  |0 (DE-588)1048670813  |0 (DE-627)780888235  |0 (DE-576)402969502  |4 aut 
700 1 |a Yard, Benito A.  |d 1961-  |e VerfasserIn  |0 (DE-588)1025110633  |0 (DE-627)721145892  |0 (DE-576)369951735  |4 aut 
700 1 |a Krämer, Bernhard  |d 1957-  |e VerfasserIn  |0 (DE-588)14017589X  |0 (DE-627)70358927X  |0 (DE-576)314926852  |4 aut 
700 1 |a Benck, Urs Tobias  |d 1966-  |e VerfasserIn  |0 (DE-588)130899143  |0 (DE-627)707596653  |0 (DE-576)298403293  |4 aut 
773 0 8 |i Enthalten in  |t American journal of transplantation  |d [Amsterdam] : Elsevier, 2001  |g 18(2018), 3, Seite 704-714  |h Online-Ressource  |w (DE-627)328318353  |w (DE-600)2045621-9  |w (DE-576)094404267  |x 1600-6143  |7 nnas  |a Impact of spontaneous donor hypothermia on graft outcomes after kidney transplantation 
773 1 8 |g volume:18  |g year:2018  |g number:3  |g pages:704-714  |g extent:11  |a Impact of spontaneous donor hypothermia on graft outcomes after kidney transplantation 
856 4 0 |u http://dx.doi.org/10.1111/ajt.14541  |x Verlag  |x Resolving-System  |3 Volltext 
856 4 0 |u https://onlinelibrary.wiley.com/doi/abs/10.1111/ajt.14541  |x Verlag  |3 Volltext 
951 |a AR 
992 |a 20180704 
993 |a Article 
994 |a 2018 
998 |g 130899143  |a Benck, Urs Tobias  |m 130899143:Benck, Urs Tobias  |d 60000  |d 61400  |e 60000PB130899143  |e 61400PB130899143  |k 0/60000/  |k 1/60000/61400/  |p 7  |y j 
998 |g 14017589X  |a Krämer, Bernhard  |m 14017589X:Krämer, Bernhard  |d 60000  |d 61400  |e 60000PK14017589X  |e 61400PK14017589X  |k 0/60000/  |k 1/60000/61400/  |p 6 
998 |g 1025110633  |a Yard, Benito A.  |m 1025110633:Yard, Benito A.  |d 60000  |d 61400  |e 60000PY1025110633  |e 61400PY1025110633  |k 0/60000/  |k 1/60000/61400/  |p 5 
998 |g 1048670813  |a Schmitt, Wilhelm  |m 1048670813:Schmitt, Wilhelm  |d 60000  |d 61400  |e 60000PS1048670813  |e 61400PS1048670813  |k 0/60000/  |k 1/60000/61400/  |p 4 
998 |g 1162207027  |a Drüschler, Felix  |m 1162207027:Drüschler, Felix  |d 910000  |e 910000PD1162207027  |k 0/910000/  |p 3 
998 |g 1025476972  |a Mundt, Heiko  |m 1025476972:Mundt, Heiko  |d 60000  |d 61400  |e 60000PM1025476972  |e 61400PM1025476972  |k 0/60000/  |k 1/60000/61400/  |p 2 
998 |g 1028873905  |a Schnülle, Peter  |m 1028873905:Schnülle, Peter  |d 60000  |d 61400  |e 60000PS1028873905  |e 61400PS1028873905  |k 0/60000/  |k 1/60000/61400/  |p 1  |x j 
999 |a KXP-PPN1577261461  |e 3016085283 
BIB |a Y 
SER |a journal 
JSO |a {"origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"2018"}],"relHost":[{"note":["Gesehen am 16.06.25"],"physDesc":[{"extent":"Online-Ressource"}],"part":{"pages":"704-714","year":"2018","issue":"3","text":"18(2018), 3, Seite 704-714","extent":"11","volume":"18"},"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title_sort":"American journal of transplantation","subtitle":"official journal of the American Society of Transplant Surgeons (ASTS) and the American Society of Transplantation (AST)","title":"American journal of transplantation"}],"disp":"Impact of spontaneous donor hypothermia on graft outcomes after kidney transplantationAmerican journal of transplantation","language":["eng"],"recId":"328318353","id":{"doi":["10.1111/(ISSN)1600-6143"],"issn":["1600-6143"],"eki":["328318353"],"zdb":["2045621-9"]},"pubHistory":["1.2001 -"],"origin":[{"dateIssuedKey":"2001","publisherPlace":"[Amsterdam] ; Copenhagen ; Oxford [u.a.] ; Oxford [u.a.]","dateIssuedDisp":"2001-","publisher":"Elsevier ; Munksgaard ; Blackwell ; Wiley-Blackwell"}]}],"physDesc":[{"extent":"11 S."}],"note":["Gesehen am 04.07.2018"],"language":["eng"],"id":{"eki":["1577261461"],"doi":["10.1111/ajt.14541"]},"recId":"1577261461","name":{"displayForm":["P. Schnuelle, H.M. Mundt, F. Drüschler, W.H. Schmitt, B.A. Yard, B.K. Krämer, U. Benck"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"role":"aut","family":"Schnülle","given":"Peter","roleDisplay":"VerfasserIn","display":"Schnülle, Peter"},{"given":"Heiko","roleDisplay":"VerfasserIn","display":"Mundt, Heiko","family":"Mundt","role":"aut"},{"role":"aut","family":"Drüschler","display":"Drüschler, Felix","roleDisplay":"VerfasserIn","given":"Felix"},{"family":"Schmitt","display":"Schmitt, Wilhelm","roleDisplay":"VerfasserIn","given":"Wilhelm","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Benito A.","display":"Yard, Benito A.","family":"Yard"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Bernhard","display":"Krämer, Bernhard","family":"Krämer"},{"role":"aut","given":"Urs Tobias","roleDisplay":"VerfasserIn","display":"Benck, Urs Tobias","family":"Benck"}],"title":[{"title":"Impact of spontaneous donor hypothermia on graft outcomes after kidney transplantation","title_sort":"Impact of spontaneous donor hypothermia on graft outcomes after kidney transplantation"}]} 
SRT |a SCHNUELLEPIMPACTOFSP2018 

Ähnliche Einträge