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Soluble TREM-1 as a diagnostic and prognostic biomarker in patients with septic shock: an observational clinical study

Objectives: The impact of TREM-1-mediated inflammation was investigated in different inflammatory settings.Methods: Secondary analyses of an observational clinical pilot study, including 60 patients with septic shock, 30 postoperative controls and 30 healthy volunteers.Results: Plasma levels of sTRE...

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Main Authors: Brenner, Thorsten (Author) , Uhle, Florian (Author) , Fleming, Thomas (Author) , Wieland, Matthias (Author) , Schmoch, Thomas (Author) , Schmitt, Felix (Author) , Schmidt, Karsten (Author) , Živković, Aleksandar (Author) , Bruckner, Thomas (Author) , Weigand, Markus A. (Author) , Hofer, Stefan (Author)
Format: Article (Journal)
Language:English
Published: 2017
In: Biomarkers
Year: 2017, Volume: 22, Issue: 1, Pages: 63-69
ISSN:1366-5804
DOI:10.1080/1354750X.2016.1204005
Online Access:Verlag, Volltext: http://dx.doi.org/10.1080/1354750X.2016.1204005
Verlag, Volltext: https://doi.org/10.1080/1354750X.2016.1204005
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Author Notes:Thorsten Brenner, Florian Uhle, Thomas Fleming, Matthias Wieland, Thomas Schmoch, Felix Schmitt, Karsten Schmidt, Aleksandar R. Zivkovic, Thomas Bruckner, Markus A. Weigand & Stefan Hofer
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Summary:Objectives: The impact of TREM-1-mediated inflammation was investigated in different inflammatory settings.Methods: Secondary analyses of an observational clinical pilot study, including 60 patients with septic shock, 30 postoperative controls and 30 healthy volunteers.Results: Plasma levels of sTREM-1 were found to identify patients with septic shock more effectively than procalcitonin and C-reactive protein. Moreover, sTREM-1 was identified to be an early predictor for survival in patients with septic shock.Conclusion: Due to its diagnostic as well as prognostic value in sepsis syndrome, implementation of sTREM-1 measurements in routine diagnostics should be taken into account.
Item Description:Published online: 06 Jul 2016
Gesehen am 09.07.2018
Physical Description:Online Resource
ISSN:1366-5804
DOI:10.1080/1354750X.2016.1204005

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