RNA mediated toll-like receptor stimulation in health and disease
Besides their well known functions in storage and translation of information nucleic acids have emerged as a target of pattern recognition receptors that drive activation of innate immunity. Due to the paucity of building block monomers used in nucleic acids, discrimination of host and microbial nuc...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
23 May 2012
|
| In: |
RNA biology
Year: 2012, Jahrgang: 9, Heft: 6, Pages: 828-842 |
| ISSN: | 1555-8584 |
| DOI: | 10.4161/rna.20206 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.4161/rna.20206 Verlag, Volltext: https://doi.org/10.4161/rna.20206 
|
| Verfasserangaben: | Alexander H. Dalpke & Mark Helm |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1577474031 | ||
| 003 | DE-627 | ||
| 005 | 20230426230627.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180710s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.4161/rna.20206 |2 doi | |
| 035 | |a (DE-627)1577474031 | ||
| 035 | |a (DE-576)507474031 | ||
| 035 | |a (DE-599)BSZ507474031 | ||
| 035 | |a (OCoLC)1341013553 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Dalpke, Alexander |d 1971- |e VerfasserIn |0 (DE-588)123821878 |0 (DE-627)706438523 |0 (DE-576)293894272 |4 aut | |
| 245 | 1 | 0 | |a RNA mediated toll-like receptor stimulation in health and disease |c Alexander H. Dalpke & Mark Helm |
| 264 | 1 | |c 23 May 2012 | |
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 10.07.2018 | ||
| 520 | |a Besides their well known functions in storage and translation of information nucleic acids have emerged as a target of pattern recognition receptors that drive activation of innate immunity. Due to the paucity of building block monomers used in nucleic acids, discrimination of host and microbial nucleic acids as a means of self/foreign discrimination is a complicated task. Pattern recognition receptors rely on discrimination by sequence, structural features and spatial compartmentalization to differentiate microbial derived nucleic acids from host ones. Microbial nucleic acid detection is important for the sensing of infectious danger and initiating an immune response to microbial attack. Failures in the underlying recognitions systems can have severe consequences: thus, inefficient recognition of microbial nucleic acids may increase susceptibility to infectious diseases. On the other hand, excessive immune responses as a result of failed self/foreign discrimination are associated with autoimmune diseases. This review gives a general overview over the underlying concepts of nucleic acid sensing by Toll-like receptors. Within this general framework, we focus on bacterial RNA and synthetic RNA oligomers. | ||
| 650 | 4 | |a autoimmunity | |
| 650 | 4 | |a infections | |
| 650 | 4 | |a innate immunity | |
| 650 | 4 | |a modifications | |
| 650 | 4 | |a Nucleic acids | |
| 650 | 4 | |a toll-like receptor | |
| 700 | 1 | |a Helm, Mark |d 1969- |e VerfasserIn |0 (DE-588)132228076 |0 (DE-627)519546229 |0 (DE-576)25150431X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t RNA biology |d Philadelphia, Pa. : Taylor & Francis, 2004 |g 9(2012), 6, Seite 828-842 |h Online-Ressource |w (DE-627)393747174 |w (DE-600)2159587-2 |w (DE-576)321220188 |x 1555-8584 |7 nnas |a RNA mediated toll-like receptor stimulation in health and disease |
| 773 | 1 | 8 | |g volume:9 |g year:2012 |g number:6 |g pages:828-842 |g extent:15 |a RNA mediated toll-like receptor stimulation in health and disease |
| 856 | 4 | 0 | |u http://dx.doi.org/10.4161/rna.20206 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://doi.org/10.4161/rna.20206 |x Verlag |x Resolving-System |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180710 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 132228076 |a Helm, Mark |m 132228076:Helm, Mark |p 2 |y j | ||
| 998 | |g 123821878 |a Dalpke, Alexander |m 123821878:Dalpke, Alexander |d 910000 |d 911700 |e 910000PD123821878 |e 911700PD123821878 |k 0/910000/ |k 1/910000/911700/ |p 1 |x j | ||
| 999 | |a KXP-PPN1577474031 |e 3017257673 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1577474031","title":[{"title_sort":"RNA mediated toll-like receptor stimulation in health and disease","title":"RNA mediated toll-like receptor stimulation in health and disease"}],"name":{"displayForm":["Alexander H. Dalpke & Mark Helm"]},"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"physDesc":[{"extent":"15 S."}],"note":["Gesehen am 10.07.2018"],"person":[{"given":"Alexander","display":"Dalpke, Alexander","role":"aut","roleDisplay":"VerfasserIn","family":"Dalpke"},{"display":"Helm, Mark","role":"aut","given":"Mark","family":"Helm","roleDisplay":"VerfasserIn"}],"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"23 May 2012"}],"id":{"eki":["1577474031"],"doi":["10.4161/rna.20206"]},"relHost":[{"id":{"zdb":["2159587-2"],"eki":["393747174"],"issn":["1555-8584"]},"origin":[{"publisherPlace":"Philadelphia, Pa. ; Georgetown, Tex.","dateIssuedDisp":"2004-","publisher":"Taylor & Francis ; Landes Bioscience","dateIssuedKey":"2004"}],"note":["Gesehen am 17.08.2020"],"physDesc":[{"extent":"Online-Ressource"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"pubHistory":["1.2004 -"],"part":{"extent":"15","volume":"9","issue":"6","year":"2012","pages":"828-842","text":"9(2012), 6, Seite 828-842"},"disp":"RNA mediated toll-like receptor stimulation in health and diseaseRNA biology","title":[{"title_sort":"RNA biology","title":"RNA biology"}],"recId":"393747174"}]} | ||
| SRT | |a DALPKEALEXRNAMEDIATE2320 | ||