Circulating tumour cell release after cement augmentation of vertebral metastases
Cement augmentation via percutaneous vertebroplasty or kyphoplasty for treatment of spinal metastasis is a well-established treatment option. We assessed whether elevated intrametastatic pressure during cement augmentation results in an increased dissemination of tumour cells into the vascular circu...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
03 August 2017
|
| In: |
Scientific reports
Year: 2017, Jahrgang: 7 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-017-07649-z |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/s41598-017-07649-z Verlag, kostenfrei, Volltext: https://www-nature-com.ezproxy.medma.uni-heidelberg.de/articles/s41598-017-07649-z 
|
| Verfasserangaben: | Malte Mohme, Sabine Riethdorf, Marc Dreimann, Stefan Werner, Cecile L. Maire, Simon A. Joosse, Frederic Bludau, Volkmar Mueller, Rui P.L. Neves, Nikolas H. Stoecklein, Katrin Lamszus, Manfred Westphal, Klaus Pantel, Harriet Wikman and Sven O. Eicker |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1577476794 | ||
| 003 | DE-627 | ||
| 005 | 20220814190349.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180710s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41598-017-07649-z |2 doi | |
| 035 | |a (DE-627)1577476794 | ||
| 035 | |a (DE-576)507476794 | ||
| 035 | |a (DE-599)BSZ507476794 | ||
| 035 | |a (OCoLC)1341013659 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Mohme, Malte Eberhard |d 1986- |e VerfasserIn |0 (DE-588)1054323887 |0 (DE-627)791305708 |0 (DE-576)410158593 |4 aut | |
| 245 | 1 | 0 | |a Circulating tumour cell release after cement augmentation of vertebral metastases |c Malte Mohme, Sabine Riethdorf, Marc Dreimann, Stefan Werner, Cecile L. Maire, Simon A. Joosse, Frederic Bludau, Volkmar Mueller, Rui P.L. Neves, Nikolas H. Stoecklein, Katrin Lamszus, Manfred Westphal, Klaus Pantel, Harriet Wikman and Sven O. Eicker |
| 264 | 1 | |c 03 August 2017 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 10.07.2018 | ||
| 520 | |a Cement augmentation via percutaneous vertebroplasty or kyphoplasty for treatment of spinal metastasis is a well-established treatment option. We assessed whether elevated intrametastatic pressure during cement augmentation results in an increased dissemination of tumour cells into the vascular circulation. We prospectively collected blood from patients with osteolytic spinal column metastases and analysed the prevalence of circulating tumour cells (CTCs) at three time-points: preoperatively, 20 minutes after cement augmentation, and 3-5 days postoperatively. Enrolling 21 patients, including 13 breast- (61.9%), 5 lung- (23.8%), and one (4.8%) colorectal-, renal-, and prostate-carcinoma patient each, we demonstrate a significant 1.8-fold increase of EpCAM+/K+ CTCs in samples taken 20 minutes post-cement augmentation (P < 0.0001). Despite increased mechanical CTC dissemination due to cement augmentation, follow-up blood draws demonstrated that no long-term increase of CTCs was present. Array-CGH analysis revealed a specific profile of the CTC collected 20 minutes after cement augmentation. This is the first study to report that peripheral CTCs are temporarily increased due to vertebral cement augmentation procedures. Our findings provide a rationale for the development of new prophylactic strategies to reduce the increased release of CTC after cement augmentation of osteolytic spinal metastases. | ||
| 700 | 1 | |a Bludau, Frederic |d 1981- |e VerfasserIn |0 (DE-588)1019241691 |0 (DE-627)716981432 |0 (DE-576)365495026 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Scientific reports |d [London] : Springer Nature, 2011 |g 7(2017) Artikel-Nummer 7196, 9 Seiten |h Online-Ressource |w (DE-627)663366712 |w (DE-600)2615211-3 |w (DE-576)346641179 |x 2045-2322 |7 nnas |a Circulating tumour cell release after cement augmentation of vertebral metastases |
| 773 | 1 | 8 | |g volume:7 |g year:2017 |g extent:9 |a Circulating tumour cell release after cement augmentation of vertebral metastases |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41598-017-07649-z |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www-nature-com.ezproxy.medma.uni-heidelberg.de/articles/s41598-017-07649-z |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180710 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 1019241691 |a Bludau, Frederic |m 1019241691:Bludau, Frederic |d 60000 |d 62400 |e 60000PB1019241691 |e 62400PB1019241691 |k 0/60000/ |k 1/60000/62400/ |p 7 | ||
| 999 | |a KXP-PPN1577476794 |e 3017260887 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 10.07.2018"],"id":{"doi":["10.1038/s41598-017-07649-z"],"eki":["1577476794"]},"recId":"1577476794","physDesc":[{"extent":"9 S."}],"relHost":[{"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"origin":[{"publisher":"Springer Nature ; Nature Publishing Group","dateIssuedDisp":"2011-","dateIssuedKey":"2011","publisherPlace":"[London] ; London"}],"pubHistory":["1, article number 1 (2011)-"],"title":[{"title":"Scientific reports","title_sort":"Scientific reports"}],"disp":"Circulating tumour cell release after cement augmentation of vertebral metastasesScientific reports","physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["2045-2322"],"eki":["663366712"],"zdb":["2615211-3"]},"recId":"663366712","note":["Gesehen am 12.07.24"],"part":{"text":"7(2017) Artikel-Nummer 7196, 9 Seiten","volume":"7","year":"2017","extent":"9"}}],"title":[{"title":"Circulating tumour cell release after cement augmentation of vertebral metastases","title_sort":"Circulating tumour cell release after cement augmentation of vertebral metastases"}],"origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"03 August 2017"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"name":{"displayForm":["Malte Mohme, Sabine Riethdorf, Marc Dreimann, Stefan Werner, Cecile L. Maire, Simon A. Joosse, Frederic Bludau, Volkmar Mueller, Rui P.L. Neves, Nikolas H. Stoecklein, Katrin Lamszus, Manfred Westphal, Klaus Pantel, Harriet Wikman and Sven O. Eicker"]},"person":[{"role":"aut","family":"Mohme","given":"Malte Eberhard","display":"Mohme, Malte Eberhard"},{"role":"aut","given":"Frederic","family":"Bludau","display":"Bludau, Frederic"}]} | ||
| SRT | |a MOHMEMALTECIRCULATIN0320 | ||