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Systemische Amyloidosen

Amyloidoses are rare protein folding disorders, in which proteins are deposited as insoluble fibrillar aggregates due to a conformational change. This can occur in a local or systemic form. Systemic amyloidoses are life-threatening complications of monoclonal gammopathy, chronic inflammatory disease...

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Bibliographic Details
Main Authors: Schönland, Stefan (Author) , Blank, Norbert (Author) , Kristen, Arnt (Author) , Beimler, Jörg (Author) , Ganten, Tom M. (Author) , Hegenbart, Ute (Author)
Format: Article (Journal)
Language:German
Published: 2012
In: Der Internist
Year: 2011, Volume: 53, Issue: 1, Pages: 51-64
ISSN:1432-1289
DOI:10.1007/s00108-011-2952-y
Online Access:Verlag, Volltext: http://dx.doi.org/10.1007/s00108-011-2952-y
Verlag, Volltext: https://link.springer.com/article/10.1007/s00108-011-2952-y
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Author Notes:S. Schönland, N. Blank, A.V. Kristen, J. Beimler, T. Ganten, U. Hegenbart
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Summary:Amyloidoses are rare protein folding disorders, in which proteins are deposited as insoluble fibrillar aggregates due to a conformational change. This can occur in a local or systemic form. Systemic amyloidoses are life-threatening complications of monoclonal gammopathy, chronic inflammatory diseases or within hereditary diseases. The causative treatment of amyloidosis is the reduction of the amyloid precursor protein by chemotherapy, anti-inflammatory treatment, or liver transplantation. Early diagnosis of the disease is essential in order to effectively treat patients and avoid further deterioration of organ functions.
Item Description:Gesehen am 11.07.2018
Online publiziert: 27. Oktober 2011
Physical Description:Online Resource
ISSN:1432-1289
DOI:10.1007/s00108-011-2952-y

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