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Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate

An oncometabolite produced by tumor cells acts as a paracrine immunosuppressant dampening antitumor T cell responses in glioma.

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Bibliographic Details
Main Authors: Bunse, Lukas (Author) , Pusch, Stefan (Author) , Bunse, Theresa (Author) , Sahm, Felix (Author) , Sonner, Jana K. (Author) , Deumelandt, Katrin (Author) , Uhlig, Stefanie (Author) , Keßler, Tobias (Author) , Breckwoldt, Michael O. (Author) , Meyer, Jochen (Author) , Habel, Antje (Author) , Poschet, Gernot (Author) , Ratliff, Miriam (Author) , Schrimpf, Daniel (Author) , Okun, Jürgen G. (Author) , Herold-Mende, Christel (Author) , Bieback, Karen (Author) , Hänggi, Daniel (Author) , Deimling, Andreas von (Author) , Wick, Wolfgang (Author) , Platten, Michael (Author)
Format: Article (Journal)
Language:English
Published: 09 July 2018
In: Nature medicine
Year: 2018, Volume: 24, Pages: 1192-1203
ISSN:1546-170X
DOI:10.1038/s41591-018-0095-6
Online Access:Verlag, Volltext: http://dx.doi.org/10.1038/s41591-018-0095-6
Verlag, Volltext: https://www.nature.com/articles/s41591-018-0095-6
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Author Notes:Lukas Bunse, Stefan Pusch, Theresa Bunse, Felix Sahm, Khwab Sanghvi, Mirco Friedrich, Dalia Alansary, Jana K. Sonner, Edward Green, Katrin Deumelandt, Michael Kilian, Cyril Neftel, Stefanie Uhlig, Tobias Kessler, Anna von Landenberg, Anna S. Berghoff, Kelly Marsh, Mya Steadman, Dongwei Zhu, Brandon Nicolay, Benedikt Wiestler, Michael O. Breckwoldt, Ruslan Al-Ali, Simone Karcher-Bausch, Matthias Bozza, Iris Oezen, Magdalena Kramer, Jochen Meyer, Antje Habel, Jessica Eisel, Gernot Poschet, Michael Weller, Matthias Preusser, Minou Nadji-Ohl, Niklas Thon, Michael C. Burger, Patrick N. Harter, Miriam Ratliff, Richard Harbottle, Axel Benner, Daniel Schrimpf, Jürgen Okun, Christel Herold-Mende, Sevin Turcan, Stefan Kaulfuss, Holger Hess‐Stumpp, Karen Bieback, Daniel P. Cahill, Karl H. Plate, Daniel Hänggi, Marion Dorsch, Mario L. Suvà, Barbara A. Niemeyer, Andreas von Deimling, Wolfgang Wick, Michael Platten
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Summary:An oncometabolite produced by tumor cells acts as a paracrine immunosuppressant dampening antitumor T cell responses in glioma.
Item Description:Gesehen am 11.07.2018
Physical Description:Online Resource
ISSN:1546-170X
DOI:10.1038/s41591-018-0095-6

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