The shedded ectodomain of Lyve-1 expressed on M2-like tumor-associated macrophages inhibits melanoma cell proliferation
Targeting immune cells that support tumor growth is an effective therapeutic strategy in tumor entities such as melanoma. M2-like tumor-associated macrophages (TAM) sustain tumor growth by secreting anti-inflammatory cytokines, proteases and growth factors. In this study, we show that a protein deri...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 10, 2017
|
| In: |
OncoTarget
Year: 2017, Jahrgang: 8, Heft: 61, Pages: 103682-103692 |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.21771 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.18632/oncotarget.21771 Verlag, Volltext: http://www.oncotarget.com/fulltext/21771 
|
| Verfasserangaben: | Claudia Dollt, Kathrin Becker, Julia Michel, Susanne Melchers, Cleo-Aron Weis, Kai Schledzewski, Andreas Krewer, Loreen Kloss, Christoffer Gebhardt, Jochen Utikal and Astrid Schmieder |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1577533054 | ||
| 003 | DE-627 | ||
| 005 | 20220814191013.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180712s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.18632/oncotarget.21771 |2 doi | |
| 035 | |a (DE-627)1577533054 | ||
| 035 | |a (DE-576)507533054 | ||
| 035 | |a (DE-599)BSZ507533054 | ||
| 035 | |a (OCoLC)1341013472 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Dollt, Claudia |e VerfasserIn |0 (DE-588)112275907X |0 (DE-627)876141807 |0 (DE-576)481477373 |4 aut | |
| 245 | 1 | 4 | |a The shedded ectodomain of Lyve-1 expressed on M2-like tumor-associated macrophages inhibits melanoma cell proliferation |c Claudia Dollt, Kathrin Becker, Julia Michel, Susanne Melchers, Cleo-Aron Weis, Kai Schledzewski, Andreas Krewer, Loreen Kloss, Christoffer Gebhardt, Jochen Utikal and Astrid Schmieder |
| 264 | 1 | |c October 10, 2017 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 12.07.2018 | ||
| 520 | |a Targeting immune cells that support tumor growth is an effective therapeutic strategy in tumor entities such as melanoma. M2-like tumor-associated macrophages (TAM) sustain tumor growth by secreting anti-inflammatory cytokines, proteases and growth factors. In this study, we show that a protein derived from M2-like macrophages namely the shedded ectodomain of Lyve-1 (sLyve-1) decreases human HT144 and murine B16F1 melanoma cell proliferation significantly by acting as a decoy receptor for lowmolecular weight hyaluronic acid (LMW-HA) although the LMW-HA/Lyve-1 interaction on lymphatic endothelial cells has been described to induce lymphangiogenesis. This is in line with our finding that the number of LYVE-1+ TAM decreases in higher human melanoma stages and that the early growth of B16 transplant tumors is enhanced in Lyve-1 knockout mice when compared to wild-type mice due to an increased melanoma cell proliferation. LYVE-1 expressing TAM are however true M2 macrophages as they coexpress typical M2-markers such as CD163 and CD206. The results of the present study highlight the necessity to carefully determine the net effect particular TAM subpopulations have on tumors before establishing a treatment to target these immune cells. | ||
| 700 | 1 | |a Becker, Kathrin |e VerfasserIn |0 (DE-588)1162593520 |0 (DE-627)1026714559 |0 (DE-576)507520505 |4 aut | |
| 700 | 1 | |a Michel, Julia |e VerfasserIn |0 (DE-588)1057943002 |0 (DE-627)795558546 |0 (DE-576)413947505 |4 aut | |
| 700 | 1 | |a Melchers, Susanne |d 1993- |e VerfasserIn |0 (DE-588)1116108151 |0 (DE-627)87018170X |0 (DE-576)478169388 |4 aut | |
| 700 | 1 | |a Weis, Cleo-Aron Thias |d 1985- |e VerfasserIn |0 (DE-588)1062803752 |0 (DE-627)806961198 |0 (DE-576)42022730X |4 aut | |
| 700 | 1 | |a Schledzewski, Kai |d 1967- |e VerfasserIn |0 (DE-588)120249057 |0 (DE-627)696500485 |0 (DE-576)292119127 |4 aut | |
| 700 | 1 | |a Krewer, Andreas |d 1988- |e VerfasserIn |0 (DE-588)116259151X |0 (DE-627)1026712130 |0 (DE-576)507518039 |4 aut | |
| 700 | 1 | |a Kloss, Loreen |e VerfasserIn |0 (DE-588)1162591366 |0 (DE-627)102671186X |0 (DE-576)507518101 |4 aut | |
| 700 | 1 | |a Gebhardt, Christoffer |d 1976- |e VerfasserIn |0 (DE-588)13051151X |0 (DE-627)503031666 |0 (DE-576)298240289 |4 aut | |
| 700 | 1 | |a Utikal, Jochen |d 1974- |e VerfasserIn |0 (DE-588)1026463750 |0 (DE-627)726765015 |0 (DE-576)371816580 |4 aut | |
| 700 | 1 | |a Schmieder, Astrid |d 1979- |e VerfasserIn |0 (DE-588)1034568361 |0 (DE-627)745869769 |0 (DE-576)382211693 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t OncoTarget |d [Erscheinungsort nicht ermittelbar] : Impact Journals LLC, 2010 |g 8(2017), 61, Seite 103682-103692 |h Online-Ressource |w (DE-627)63035975X |w (DE-600)2560162-3 |w (DE-576)325343764 |x 1949-2553 |7 nnas |a The shedded ectodomain of Lyve-1 expressed on M2-like tumor-associated macrophages inhibits melanoma cell proliferation |
| 773 | 1 | 8 | |g volume:8 |g year:2017 |g number:61 |g pages:103682-103692 |g extent:11 |a The shedded ectodomain of Lyve-1 expressed on M2-like tumor-associated macrophages inhibits melanoma cell proliferation |
| 856 | 4 | 0 | |u http://dx.doi.org/10.18632/oncotarget.21771 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.oncotarget.com/fulltext/21771 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180712 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 1034568361 |a Schmieder, Astrid |m 1034568361:Schmieder, Astrid |d 60000 |d 61900 |e 60000PS1034568361 |e 61900PS1034568361 |k 0/60000/ |k 1/60000/61900/ | ||
| 998 | |g 1026463750 |a Utikal, Jochen |m 1026463750:Utikal, Jochen |d 60000 |e 60000PU1026463750 |k 0/60000/ | ||
| 998 | |g 13051151X |a Gebhardt, Christoffer |m 13051151X:Gebhardt, Christoffer |d 60000 |d 61900 |e 60000PG13051151X |e 61900PG13051151X |k 0/60000/ |k 1/60000/61900/ |p 9 | ||
| 998 | |g 1162591366 |a Kloss, Loreen |m 1162591366:Kloss, Loreen |d 140000 |d 140001 |e 140000PK1162591366 |e 140001PK1162591366 |k 0/140000/ |k 1/140000/140001/ | ||
| 998 | |g 116259151X |a Krewer, Andreas |m 116259151X:Krewer, Andreas |d 60000 |e 60000PK116259151X |k 0/60000/ | ||
| 998 | |g 120249057 |a Schledzewski, Kai |m 120249057:Schledzewski, Kai |d 60000 |d 61900 |e 60000PS120249057 |e 61900PS120249057 |k 0/60000/ |k 1/60000/61900/ | ||
| 998 | |g 1062803752 |a Weis, Cleo-Aron Thias |m 1062803752:Weis, Cleo-Aron Thias |d 60000 |d 63400 |e 60000PW1062803752 |e 63400PW1062803752 |k 0/60000/ |k 1/60000/63400/ | ||
| 998 | |g 1116108151 |a Melchers, Susanne |m 1116108151:Melchers, Susanne |d 60000 |e 60000PM1116108151 |k 0/60000/ | ||
| 998 | |g 1057943002 |a Michel, Julia |m 1057943002:Michel, Julia |d 60000 |d 63500 |e 60000PM1057943002 |e 63500PM1057943002 |k 0/60000/ |k 1/60000/63500/ | ||
| 998 | |g 1162593520 |a Becker, Kathrin |m 1162593520:Becker, Kathrin |d 140000 |d 140001 |e 140000PB1162593520 |e 140001PB1162593520 |k 0/140000/ |k 1/140000/140001/ | ||
| 998 | |g 112275907X |a Dollt, Claudia |m 112275907X:Dollt, Claudia |d 140000 |d 140001 |e 140000PD112275907X |e 140001PD112275907X |k 0/140000/ |k 1/140000/140001/ |p 1 |x j | ||
| 999 | |a KXP-PPN1577533054 |e 3017448584 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"title":[{"title_sort":"OncoTarget","title":"OncoTarget","subtitle":"open access impact journal"}],"pubHistory":["1.2010,Mai -"],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 16.08.2018"],"part":{"text":"8(2017), 61, Seite 103682-103692","extent":"11","volume":"8","pages":"103682-103692","issue":"61","year":"2017"},"id":{"issn":["1949-2553"],"zdb":["2560162-3"],"eki":["63035975X"]},"origin":[{"publisherPlace":"[Erscheinungsort nicht ermittelbar]","dateIssuedDisp":"2010-","publisher":"Impact Journals LLC","dateIssuedKey":"2010"}],"disp":"The shedded ectodomain of Lyve-1 expressed on M2-like tumor-associated macrophages inhibits melanoma cell proliferationOncoTarget","recId":"63035975X"}],"note":["Gesehen am 12.07.2018"],"name":{"displayForm":["Claudia Dollt, Kathrin Becker, Julia Michel, Susanne Melchers, Cleo-Aron Weis, Kai Schledzewski, Andreas Krewer, Loreen Kloss, Christoffer Gebhardt, Jochen Utikal and Astrid Schmieder"]},"recId":"1577533054","id":{"doi":["10.18632/oncotarget.21771"],"eki":["1577533054"]},"origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"October 10, 2017"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"physDesc":[{"extent":"11 S."}],"person":[{"display":"Dollt, Claudia","family":"Dollt","given":"Claudia","role":"aut"},{"display":"Becker, Kathrin","given":"Kathrin","role":"aut","family":"Becker"},{"family":"Michel","role":"aut","given":"Julia","display":"Michel, Julia"},{"role":"aut","given":"Susanne","family":"Melchers","display":"Melchers, Susanne"},{"display":"Weis, Cleo-Aron Thias","family":"Weis","role":"aut","given":"Cleo-Aron Thias"},{"family":"Schledzewski","given":"Kai","role":"aut","display":"Schledzewski, Kai"},{"family":"Krewer","given":"Andreas","role":"aut","display":"Krewer, Andreas"},{"display":"Kloss, Loreen","family":"Kloss","role":"aut","given":"Loreen"},{"family":"Gebhardt","given":"Christoffer","role":"aut","display":"Gebhardt, Christoffer"},{"display":"Utikal, Jochen","family":"Utikal","role":"aut","given":"Jochen"},{"display":"Schmieder, Astrid","family":"Schmieder","given":"Astrid","role":"aut"}],"title":[{"title":"The shedded ectodomain of Lyve-1 expressed on M2-like tumor-associated macrophages inhibits melanoma cell proliferation","title_sort":"shedded ectodomain of Lyve-1 expressed on M2-like tumor-associated macrophages inhibits melanoma cell proliferation"}]} | ||
| SRT | |a DOLLTCLAUDSHEDDEDECT1020 | ||