Elevated preoperative CEA is associated with worse survival in stage I-III rectal cancer patients
Background:The objective of this investigation was to assess whether preoperative carcinoembryonic antigen (CEA) level is an independent predictor of overall survival in rectal cancer patients.Methods:All patients (n=504) undergoing a resection for stage I-III rectal cancer at the Kantonsspital St G...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
26 June 2012
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| In: |
British journal of cancer
Year: 2012, Volume: 107, Issue: 2, Pages: 266-274 |
| ISSN: | 1532-1827 |
| DOI: | 10.1038/bjc.2012.267 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1038/bjc.2012.267 Verlag, Volltext: https://www.nature.com/articles/bjc2012267 
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| Author Notes: | I. Tarantino, R. Warschkow, M. Worni, K. Merati-Kashani, D. Köberle, B.M. Schmied, S.A. Müller, T. Steffen, T. Cerny and U. Güller |
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| 245 | 1 | 0 | |a Elevated preoperative CEA is associated with worse survival in stage I-III rectal cancer patients |c I. Tarantino, R. Warschkow, M. Worni, K. Merati-Kashani, D. Köberle, B.M. Schmied, S.A. Müller, T. Steffen, T. Cerny and U. Güller |
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| 520 | |a Background:The objective of this investigation was to assess whether preoperative carcinoembryonic antigen (CEA) level is an independent predictor of overall survival in rectal cancer patients.Methods:All patients (n=504) undergoing a resection for stage I-III rectal cancer at the Kantonsspital St Gallen were included into a database between 1991 and 2008. The impact of preoperative CEA level on overall survival was assessed using risk-adjusted Cox proportional hazard regression models and propensity score methods.Results:In risk-adjusted Cox proportional hazard regression analyses, preoperative CEA level (hazard ratio (HR): 1.98, 95% confidence interval (CI): 1.36-2.90, P<0.001), distance from anal verge (<5 cm: HR: 1.93, 95% CI: 1.11-3.37; P=0.039), older age (HR: 1.07, 95% CI: 1.05-1.09; P<0.001), lower body mass index (HR: 0.94, 95% CI: 0.89-0.98; P=0.006), advanced tumour stage (stage II HR: 1.41, 95% CI: 0.85-2.32; stage III HR: 2.08, 95% CI: 1.31-3.31; P=0.004), R 1 resection (HR: 5.65, 95% CI: 1.59-20.1; P=0.005) and chronic kidney disease (HR: 2.28, 95% CI: 1.03-5.04; P=0.049) were all predictors for poor overall survival.Conclusion:This is one of the first investigations based on a large cohort of exclusively rectal cancer patients demonstrating that preoperative CEA level is a strong predictor of decreased overall survival. Preoperative CEA should be used as a prognostic factor in the preoperative assessment of rectal cancer patients. | ||
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