Glycogen synthase kinase is a regulator of the circadian clock of Neurospora crassa
Timekeeping by circadian clocks relies upon precise adjustment of expression levels of clock proteins. Here we identify glycogen synthase kinase (GSK) as a novel and critical component of the circadian clock of Neurospora crassa that regulates the abundance of its core transcription factor white col...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 6, 2012
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| In: |
The journal of biological chemistry
Year: 2012, Jahrgang: 287, Heft: 44, Pages: 36936-36943 |
| ISSN: | 1083-351X |
| DOI: | 10.1074/jbc.M112.396622 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1074/jbc.M112.396622 Verlag, kostenfrei, Volltext: http://www.jbc.org/content/287/44/36936 
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| Verfasserangaben: | Özgür Tataroğlu, Linda Lauinger, Gencer Sancar, Katharina Jakob, Michael Brunner, and Axel C.R. Diernfellner |
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| 520 | |a Timekeeping by circadian clocks relies upon precise adjustment of expression levels of clock proteins. Here we identify glycogen synthase kinase (GSK) as a novel and critical component of the circadian clock of Neurospora crassa that regulates the abundance of its core transcription factor white collar complex (WCC) on a post-transcriptional level. We show that GSK specifically binds and phosphorylates both subunits of the WCC. Reduced expression of GSK promotes an increased accumulation of WC-1, the limiting factor of the WCC, causing an acceleration of the circadian clock and a shorter free-running period. | ||
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