Cyclophosphamide promotes chronic inflammation-dependent immunosuppression and prevents antitumor response in melanoma

Low-dose cyclophosphamide (CP) therapy induces immunogenic tumor cell death and decreases regulatory T cell (Treg) numbers in mice with transplantable tumors. Using the ret transgenic murine melanoma model that resembles human melanoma, we detected no beneficial antitumor effects with such treatment...

Full description

Bibliographic Details

Main Authors:	Sevko, Alexandra (Author) , Michels, Tillmann (Author) , Umansky, Ludmila (Author) , Ramacher, Marcel (Author) , Umansky, Viktor (Author)
Format:	Article (Journal)
Language:	English
Published:	2013
In:	The journal of investigative dermatology Year: 2013, Volume: 133, Issue: 6, Pages: 1610-1619
ISSN:	1523-1747
DOI:	10.1038/jid.2012.444
Online Access:	Verlag, Volltext: http://dx.doi.org/10.1038/jid.2012.444 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0022202X15362989
Author Notes:	Alexandra Sevko, Moshe Sade-Feldman, Julia Kanterman, Tillmann Michels, Christine S. Falk, Ludmila Umansky, Marcel Ramacher, Masashi Kato, Dirk Schadendorf, Michal Baniyash and Viktor Umansky