A population-based prospective study of optic neuritis
Background:Optic neuritis (ON) is often associated with multiple sclerosis (MS). Early diagnosis is critical to optimal patient management.Objective:To estimate the incidence of acute ON and the rates of conversion to MS and antibody-mediated ON.Method:Population-based prospective study was performe...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 5, 2017
|
| In: |
Multiple sclerosis journal
Year: 2017, Jahrgang: 23, Heft: 14, Pages: 1893-1901 |
| ISSN: | 1477-0970 |
| DOI: | 10.1177/1352458517734070 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1177/1352458517734070
|
| Verfasserangaben: | K. Soelberg, S. Jarius, H.P.B. Skejoe, H. Engberg, J.J. Mehlsen, A.C. Nilsson, J.S. Madsen, M. Reindl, B. Wildemann, J. Grauslund, K.O. Kyvik, T.J. Smith, S.T. Lillevang, F. Paul, B.G. Weinshenker and N. Asgari |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1577628772 | ||
| 003 | DE-627 | ||
| 005 | 20220814192702.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180716s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1177/1352458517734070 |2 doi | |
| 035 | |a (DE-627)1577628772 | ||
| 035 | |a (DE-576)507628772 | ||
| 035 | |a (DE-599)BSZ507628772 | ||
| 035 | |a (OCoLC)1341013735 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Soelberg, Kerstin |e VerfasserIn |0 (DE-588)1162858672 |0 (DE-627)1026954916 |0 (DE-576)507628705 |4 aut | |
| 245 | 1 | 2 | |a A population-based prospective study of optic neuritis |c K. Soelberg, S. Jarius, H.P.B. Skejoe, H. Engberg, J.J. Mehlsen, A.C. Nilsson, J.S. Madsen, M. Reindl, B. Wildemann, J. Grauslund, K.O. Kyvik, T.J. Smith, S.T. Lillevang, F. Paul, B.G. Weinshenker and N. Asgari |
| 264 | 1 | |c October 5, 2017 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 16.07.2018 | ||
| 520 | |a Background:Optic neuritis (ON) is often associated with multiple sclerosis (MS). Early diagnosis is critical to optimal patient management.Objective:To estimate the incidence of acute ON and the rates of conversion to MS and antibody-mediated ON.Method:Population-based prospective study was performed in patients with ON from three ophthalmological departments and 44 practicing ophthalmologists from 2014 to 2016. Ophthalmological and neurological examination, magnetic resonance imaging (MRI), determination of aquaporin-4(AQP4)-IgG and myelin-oligodendrocyte glycoprotein (MOG)-IgG were investigated blindly.Results:In all, 63 patients were evaluated and 51 fulfilled the criteria for ON. All were Caucasian, with female:male ratio of 2.2:1 and a median age of 38?years (16?66); 44 (86%) had a single episode of ON (four bilateral), while 7/51 (14%) had recurrent ON. The overall age-specific incidence was 3.28 (2.44?4.31) per 100,000 person years, 2.02 for men and 4.57 for women. At follow-up, 20 patients met the diagnostic criteria for MS, MRI lesions disseminated in space and time in 17/20 patients. AQP4-IgG was detected in none, MOG-IgG was detected in two patients.Conclusion:The prospective incidence of ON was estimated. MRI enabled a diagnosis of MS in a subgroup of patients. Antibody-mediated ON with specificity for MOG was detected in 4% of cases. | ||
| 700 | 1 | |a Jarius, Sven |e VerfasserIn |0 (DE-588)1054615918 |0 (DE-627)791654818 |0 (DE-576)410367478 |4 aut | |
| 700 | 1 | |a Wildemann, Brigitte |e VerfasserIn |0 (DE-588)110203844 |0 (DE-627)510150004 |0 (DE-576)171831330 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Multiple sclerosis journal |d London : Sage, 1995 |g 23(2017), 14, Seite 1893-1901 |h Online-Ressource |w (DE-627)320468658 |w (DE-600)2008225-3 |w (DE-576)273878239 |x 1477-0970 |7 nnas |a A population-based prospective study of optic neuritis |
| 773 | 1 | 8 | |g volume:23 |g year:2017 |g number:14 |g pages:1893-1901 |g extent:9 |a A population-based prospective study of optic neuritis |
| 856 | 4 | 0 | |u https://doi.org/10.1177/1352458517734070 |x Verlag |x Resolving-System |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180716 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 110203844 |a Wildemann, Brigitte |m 110203844:Wildemann, Brigitte |d 910000 |d 911100 |e 910000PW110203844 |e 911100PW110203844 |k 0/910000/ |k 1/910000/911100/ |p 9 | ||
| 998 | |g 1054615918 |a Jarius, Sven |m 1054615918:Jarius, Sven |d 910000 |d 911100 |e 910000PJ1054615918 |e 911100PJ1054615918 |k 0/910000/ |k 1/910000/911100/ |p 2 | ||
| 999 | |a KXP-PPN1577628772 |e 3017604985 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1577628772","physDesc":[{"extent":"9 S."}],"origin":[{"dateIssuedDisp":"October 5, 2017","dateIssuedKey":"2017"}],"relHost":[{"origin":[{"publisher":"Sage ; Stockton ; Nature ; Arnold","dateIssuedKey":"1995","publisherPlace":"London ; Basingstoke, Hampshire ; Basingstoke, Hampshire ; London","dateIssuedDisp":"1995-"}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 19.01.11"],"title":[{"title":"Multiple sclerosis journal","title_sort":"Multiple sclerosis journal"}],"physDesc":[{"extent":"Online-Ressource"}],"recId":"320468658","disp":"A population-based prospective study of optic neuritisMultiple sclerosis journal","pubHistory":["1.1995 -"],"titleAlt":[{"title":"Multiple sclerosis"}],"id":{"eki":["320468658"],"issn":["1477-0970"],"zdb":["2008225-3"]},"part":{"volume":"23","year":"2017","extent":"9","text":"23(2017), 14, Seite 1893-1901","issue":"14","pages":"1893-1901"}}],"person":[{"display":"Soelberg, Kerstin","family":"Soelberg","role":"aut","given":"Kerstin"},{"display":"Jarius, Sven","given":"Sven","role":"aut","family":"Jarius"},{"given":"Brigitte","role":"aut","family":"Wildemann","display":"Wildemann, Brigitte"}],"title":[{"title_sort":"population-based prospective study of optic neuritis","title":"A population-based prospective study of optic neuritis"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"note":["Gesehen am 16.07.2018"],"name":{"displayForm":["K. Soelberg, S. Jarius, H.P.B. Skejoe, H. Engberg, J.J. Mehlsen, A.C. Nilsson, J.S. Madsen, M. Reindl, B. Wildemann, J. Grauslund, K.O. Kyvik, T.J. Smith, S.T. Lillevang, F. Paul, B.G. Weinshenker and N. Asgari"]},"id":{"doi":["10.1177/1352458517734070"],"eki":["1577628772"]}} | ||
| SRT | |a SOELBERGKEPOPULATION5201 | ||