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The prognostic value of right ventricular long axis strain in non-ischaemic dilated cardiomyopathies using standard cardiac magnetic resonance imaging

OBJECTIVE: To investigate the association of right ventricular long axis strain (RV-LAS), a parameter of longitudinal function, with outcome in patients with non-ischaemic dilated cardiomyopathy (NIDCM). METHODS: In 441 patients with NIDCM, RV-LAS was analysed retrospectively by measuring the length...

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Hauptverfasser: Arenja, Nisha (VerfasserIn) , Riffel, Johannes (VerfasserIn) , Halder, Manuel (VerfasserIn) , Djiokou, Charly N. (VerfasserIn) , Fritz, Thomas (VerfasserIn) , André, Florian (VerfasserIn) , Siepen, Fabian aus dem (VerfasserIn) , Zelniker, Thomas (VerfasserIn) , Meder, Benjamin (VerfasserIn) , Kayvanpour, Elham (VerfasserIn) , Korosoglou, Grigorios (VerfasserIn) , Katus, Hugo (VerfasserIn) , Buß, Sebastian Johannes (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 10 February 2017
In: European radiology
Year: 2017, Jahrgang: 27, Heft: 9, Pages: 3913-3923
ISSN:1432-1084
DOI:10.1007/s00330-016-4729-0
Online-Zugang:Verlag, Volltext: https://doi.org/10.1007/s00330-016-4729-0
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Verfasserangaben:Nisha Arenja, Johannes H. Riffel, Manuel Halder, Charly N. Djiokou, Thomas Fritz, Florian Andre, Fabian Aus dem Siepen, Thomas Zelniker, Benjamin Meder, Elham Kayvanpour, Grigorios Korosoglou, Hugo A. Katus, Sebastian J. Buss
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Zusammenfassung:OBJECTIVE: To investigate the association of right ventricular long axis strain (RV-LAS), a parameter of longitudinal function, with outcome in patients with non-ischaemic dilated cardiomyopathy (NIDCM). METHODS: In 441 patients with NIDCM, RV-LAS was analysed retrospectively by measuring the length between the epicardial border of the left ventricular apex and the middle of a line connecting the origins of the tricuspidal valve leaflets in end-diastole and end-systole on non-contrast standard cine sequences. RESULTS: The primary endpoint (cardiac death or heart transplantation) occurred in 41 patients, whereas 95 reached the combined endpoint (including cardiac decompensation and sustained ventricular arrhythmias) during a median follow-up of 4.2 years. Kaplan-Meier survival curves showed a poor outcome in patients with RV-LAS values below -10% (log-rank, p < 0.0001). In a risk stratification model RV-LAS improved prediction of outcome in addition to RV ejection fraction (RVEF) and presence of late gadolinium enhancement. Assessment of RV-LAS offered incremental information compared to clinical symptoms, biomarkers and RVEF. Even in the subgroup with normal RVEF (>45%, n = 213) reduced RV-LAS was still associated with poor outcome. CONCLUSION: Assessment of RV-LAS is an independent indicator of outcome in patients with NIDCM and offers incremental information beyond clinical and cardiac MR parameters. KEY POINTS: • Impaired right ventricular longitudinal function (RV-LAS) is associated with poorer cardiac outcomes. • Poor outcome is associated with decreased RV-LAS even in patients with RVEF >45%. • Addition of RV-LAS to known risk factors enhances the power prognostic information.
Beschreibung:Gesehen am 19.07.2018
Beschreibung:Online Resource
ISSN:1432-1084
DOI:10.1007/s00330-016-4729-0

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