The phosphodiesterase 4 inhibitor apremilast inhibits Th1 but promotes Th17 responses induced by 6-sulfo LacNAc (slan) dendritic cells
Background: The phosphodiesterase 4 (PDE4) inhibitor apremilast increases cellular cAMP levels and has proven effective in the treatment of psoriasis and psoriasis arthritis. We recently described 6-sulfo LacNAc dendritic cells (slanDCs) as immature DCs in blood and as a subset of inflammatory derma...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
20 April 2017
|
| In: |
Journal of dermatological science
Year: 2017, Jahrgang: 87, Heft: 2, Pages: 110-115 |
| ISSN: | 1873-569X |
| DOI: | 10.1016/j.jdermsci.2017.04.005 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.jdermsci.2017.04.005 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0923181116307976 
|
| Verfasserangaben: | Stephanie Oehrl, Hridayesh Prakash, Annette Ebling, Nina Trenkler, Priscila Wölbing, Anja Kunze, Thomas Döbel, Marc Schmitz, Alexander Enk, Knut Schäkel |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1577768345 | ||
| 003 | DE-627 | ||
| 005 | 20231113164623.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180719s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jdermsci.2017.04.005 |2 doi | |
| 035 | |a (DE-627)1577768345 | ||
| 035 | |a (DE-576)507768345 | ||
| 035 | |a (DE-599)BSZ507768345 | ||
| 035 | |a (OCoLC)1341014024 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Oehrl, Stephanie |e VerfasserIn |0 (DE-588)1162983159 |0 (DE-627)1027082181 |0 (DE-576)507734203 |4 aut | |
| 245 | 1 | 4 | |a The phosphodiesterase 4 inhibitor apremilast inhibits Th1 but promotes Th17 responses induced by 6-sulfo LacNAc (slan) dendritic cells |c Stephanie Oehrl, Hridayesh Prakash, Annette Ebling, Nina Trenkler, Priscila Wölbing, Anja Kunze, Thomas Döbel, Marc Schmitz, Alexander Enk, Knut Schäkel |
| 264 | 1 | |c 20 April 2017 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online 20 April 2017 | ||
| 500 | |a Gesehen am 19.07.2018 | ||
| 520 | |a Background: The phosphodiesterase 4 (PDE4) inhibitor apremilast increases cellular cAMP levels and has proven effective in the treatment of psoriasis and psoriasis arthritis. We recently described 6-sulfo LacNAc dendritic cells (slanDCs) as immature DCs in blood and as a subset of inflammatory dermal DCs in psoriasis with a pronounced capacity to produce proinflammatory cytokines and to program Th17/Th1 T cell responses. Objective: The aim of this study was to investigate possible immune regulatory effects of the PDE4 inhibitor apremilast on slanDCs. Methods: In vitro studies were performed analyzing the effects of apremilast on the proinflammatory function of slanDCs and their capacity to induce Th1/Th17-biased T cell responses. Results: Increasing cAMP levels in slanDCs by PDE4 inhibition strongly reduced production of IL-12 and TNF-α. In line with these findings, co-culture experiments with apremilast-pulsed slanDCs and allogeneic T cells either from psoriasis patients or healthy controls, revealed a significant reduction of IFN-γ production and expression of the transcription factor T-bet. In parallel, production of IL-23 and IL-1ß by slanDCs was increased and co-cultured T cells revealed a largely augmented IL-17 production and an upregulated RORyt expression. Conclusions: We here demonstrate anti-inflammatory as well as Th17-promoting effects of apremilast when studying blood precursors of human inflammatory dermal dendritic cells. In the concert of the broad anti-inflammatory effects of apremilast on keratinocytes, fibroblasts and endothelial cells, the dual effect on slan+ inflammatory dermal DCs should be taken into account and may constrain therapeutic responses. | ||
| 650 | 4 | |a Apremilast | |
| 650 | 4 | |a cAMP | |
| 650 | 4 | |a PDE4 inhibitor | |
| 650 | 4 | |a Psoriasis | |
| 650 | 4 | |a slanDCs | |
| 650 | 4 | |a T cell responses | |
| 700 | 1 | |a Prakash, Hridayesh |e VerfasserIn |0 (DE-588)1154890228 |0 (DE-627)1016230605 |0 (DE-576)501296360 |4 aut | |
| 700 | 1 | |a Trenkler, Nina |d 1980- |e VerfasserIn |0 (DE-588)141954094 |0 (DE-627)704105004 |0 (DE-576)325899843 |4 aut | |
| 700 | 1 | |a Wölbing, Priscila |d 1983- |e VerfasserIn |0 (DE-588)1185081593 |0 (DE-627)1664479457 |4 aut | |
| 700 | 1 | |a Kunze, Anja |e VerfasserIn |0 (DE-588)1082431729 |0 (DE-627)84748565X |0 (DE-576)455414009 |4 aut | |
| 700 | 1 | |a Döbel, Thomas |d 1979- |e VerfasserIn |0 (DE-588)1054099197 |0 (DE-627)791033090 |0 (DE-576)409993077 |4 aut | |
| 700 | 1 | |a Enk, Alexander |d 1963- |e VerfasserIn |0 (DE-588)1032757140 |0 (DE-627)739272535 |0 (DE-576)166173517 |4 aut | |
| 700 | 1 | |a Schäkel, Knut |e VerfasserIn |0 (DE-588)1032757418 |0 (DE-627)739272896 |0 (DE-576)251064476 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of dermatological science |d Amsterdam [u.a.] : Elsevier Science, 1990 |g 87(2017), 2, Seite 110-115 |h Online-Ressource |w (DE-627)323606431 |w (DE-600)2026237-1 |w (DE-576)095238042 |x 1873-569X |7 nnas |a The phosphodiesterase 4 inhibitor apremilast inhibits Th1 but promotes Th17 responses induced by 6-sulfo LacNAc (slan) dendritic cells |
| 773 | 1 | 8 | |g volume:87 |g year:2017 |g number:2 |g pages:110-115 |g extent:6 |a The phosphodiesterase 4 inhibitor apremilast inhibits Th1 but promotes Th17 responses induced by 6-sulfo LacNAc (slan) dendritic cells |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.jdermsci.2017.04.005 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0923181116307976 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180719 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 1032757418 |a Schäkel, Knut |m 1032757418:Schäkel, Knut |d 910000 |d 911300 |e 910000PS1032757418 |e 911300PS1032757418 |k 0/910000/ |k 1/910000/911300/ |p 10 |y j | ||
| 998 | |g 1032757140 |a Enk, Alexander |m 1032757140:Enk, Alexander |d 910000 |d 911300 |e 910000PE1032757140 |e 911300PE1032757140 |k 0/910000/ |k 1/910000/911300/ |p 9 | ||
| 998 | |g 1054099197 |a Döbel, Thomas |m 1054099197:Döbel, Thomas |d 910000 |d 911300 |e 910000PD1054099197 |e 911300PD1054099197 |k 0/910000/ |k 1/910000/911300/ |p 7 | ||
| 998 | |g 1082431729 |a Kunze, Anja |m 1082431729:Kunze, Anja |p 6 | ||
| 998 | |g 1185081593 |a Wölbing, Priscila |m 1185081593:Wölbing, Priscila |d 910000 |d 911300 |e 910000PW1185081593 |e 911300PW1185081593 |k 0/910000/ |k 1/910000/911300/ |p 5 | ||
| 998 | |g 141954094 |a Trenkler, Nina |m 141954094:Trenkler, Nina |d 910000 |d 911300 |e 910000PT141954094 |e 911300PT141954094 |k 0/910000/ |k 1/910000/911300/ |p 4 | ||
| 998 | |g 1154890228 |a Prakash, Hridayesh |m 1154890228:Prakash, Hridayesh |d 910000 |d 911300 |e 910000PP1154890228 |e 911300PP1154890228 |k 0/910000/ |k 1/910000/911300/ |p 2 | ||
| 998 | |g 1162983159 |a Oehrl, Stephanie |m 1162983159:Oehrl, Stephanie |d 910000 |d 911300 |e 910000PO1162983159 |e 911300PO1162983159 |k 0/910000/ |k 1/910000/911300/ |p 1 |x j | ||
| 999 | |a KXP-PPN1577768345 |e 3018340485 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"6 S."}],"person":[{"given":"Stephanie","family":"Oehrl","display":"Oehrl, Stephanie","role":"aut"},{"role":"aut","given":"Hridayesh","display":"Prakash, Hridayesh","family":"Prakash"},{"role":"aut","display":"Trenkler, Nina","family":"Trenkler","given":"Nina"},{"role":"aut","given":"Priscila","family":"Wölbing","display":"Wölbing, Priscila"},{"role":"aut","family":"Kunze","display":"Kunze, Anja","given":"Anja"},{"family":"Döbel","display":"Döbel, Thomas","given":"Thomas","role":"aut"},{"display":"Enk, Alexander","family":"Enk","given":"Alexander","role":"aut"},{"given":"Knut","family":"Schäkel","display":"Schäkel, Knut","role":"aut"}],"title":[{"title":"The phosphodiesterase 4 inhibitor apremilast inhibits Th1 but promotes Th17 responses induced by 6-sulfo LacNAc (slan) dendritic cells","title_sort":"phosphodiesterase 4 inhibitor apremilast inhibits Th1 but promotes Th17 responses induced by 6-sulfo LacNAc (slan) dendritic cells"}],"relHost":[{"recId":"323606431","pubHistory":["1.1990 -"],"note":["Gesehen am 18.02.2020"],"disp":"The phosphodiesterase 4 inhibitor apremilast inhibits Th1 but promotes Th17 responses induced by 6-sulfo LacNAc (slan) dendritic cellsJournal of dermatological science","part":{"volume":"87","pages":"110-115","text":"87(2017), 2, Seite 110-115","year":"2017","extent":"6","issue":"2"},"title":[{"title_sort":"Journal of dermatological science","title":"Journal of dermatological science","subtitle":"the official journal of the Japanese Society for Investigative Dermatology"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedKey":"1990","publisher":"Elsevier Science","publisherPlace":"Amsterdam [u.a.]","dateIssuedDisp":"1990-"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"zdb":["2026237-1"],"issn":["1873-569X"],"eki":["323606431"]},"language":["eng"]}],"language":["eng"],"id":{"doi":["10.1016/j.jdermsci.2017.04.005"],"eki":["1577768345"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"20 April 2017"}],"name":{"displayForm":["Stephanie Oehrl, Hridayesh Prakash, Annette Ebling, Nina Trenkler, Priscila Wölbing, Anja Kunze, Thomas Döbel, Marc Schmitz, Alexander Enk, Knut Schäkel"]},"note":["Available online 20 April 2017","Gesehen am 19.07.2018"],"recId":"1577768345"} | ||
| SRT | |a OEHRLSTEPHPHOSPHODIE2020 | ||