Paternal sepsis induces alterations of the sperm methylome and dampens offspring immune responses: an animal study
Sepsis represents the utmost severe consequence of infection, involving a dysregulated and self-damaging immune response of the host. While different environmental exposures like chronic stress or malnutrition have been well described to reprogram the germline and subsequently offspring attributes,...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
28 June 2018
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| In: |
Clinical epigenetics
Year: 2018, Jahrgang: 10 |
| ISSN: | 1868-7083 |
| DOI: | 10.1186/s13148-018-0522-z |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s13148-018-0522-z Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13148-018-0522-z 
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| Verfasserangaben: | Katharina Bomans, Judith Schenz, Sandra Tamulyte, Dominik Schaack, Markus Alexander Weigand and Florian Uhle |
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| 520 | |a Sepsis represents the utmost severe consequence of infection, involving a dysregulated and self-damaging immune response of the host. While different environmental exposures like chronic stress or malnutrition have been well described to reprogram the germline and subsequently offspring attributes, the intergenerational impact of sepsis as a tremendous immunological stressor has not been examined yet. | ||
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