Saturation-recovery myocardial T 1 -mapping during systole: accurate and robust quantification in the presence of arrhythmia
Myocardial T1-mapping, a cardiac magnetic resonance imaging technique, facilitates a quantitative measure of fibrosis which is linked to numerous cardiovascular symptoms. To overcome the problems of common techniques, including lack of accuracy and robustness against partial-voluming and heart-rate...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
27 March 2018
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| In: |
Scientific reports
Year: 2018, Jahrgang: 8 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-018-23506-z |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/s41598-018-23506-z Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41598-018-23506-z 
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| Verfasserangaben: | Nadja M. Meßner, Johannes Budjan, Dirk Loßnitzer, Theano Papavassiliu, Lothar R. Schad, Sebastian Weingärtner & Frank G. Zöllner |
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| 245 | 1 | 0 | |a Saturation-recovery myocardial T 1 -mapping during systole |b accurate and robust quantification in the presence of arrhythmia |c Nadja M. Meßner, Johannes Budjan, Dirk Loßnitzer, Theano Papavassiliu, Lothar R. Schad, Sebastian Weingärtner & Frank G. Zöllner |
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| 520 | |a Myocardial T1-mapping, a cardiac magnetic resonance imaging technique, facilitates a quantitative measure of fibrosis which is linked to numerous cardiovascular symptoms. To overcome the problems of common techniques, including lack of accuracy and robustness against partial-voluming and heart-rate variability, we introduce a systolic saturation-recovery T1-mapping method. The Saturation-Pulse Prepared Heart-rate independent Inversion-Recovery (SAPPHIRE) T1-mapping method was modified to enable imaging during systole. Phantom measurements were used to evaluate the insensitivity of systolic T1-mapping towards heart-rate variability. In-vivo feasibility and accuracy were demonstrated in ten healthy volunteers with native and post-contrast T1-mappping during systole and diastole. To show benefits in the presence of RR-variability, six arrhythmic patients underwent native T1-mapping. Resulting systolic SAPPHIRE T1-values showed no dependence on arrhythmia in phantom (CoV < 1%). In-vivo, significantly lower T1 (1563 ± 56 ms, precision: 84.8 ms) and ECV-values (0.20 ± 0.03) than during diastole (T1 = 1580 ± 62 ms, p = 0.0124; precision: 60.2 ms, p = 0.03; ECV = 0.21 ± 0.03, p = 0.0098) were measured, with a strong correlation of systolic and diastolic T1 (r = 0.89). In patients, mis-triggering-induced motion caused significant imaging artifacts in diastolic T1-maps, whereas systolic T1-maps displayed resilience to arrythmia. In conclusion, the proposed method enables saturation-recovery T1-mapping during systole, providing increased robustness against partial-voluming compared to diastolic imaging, for the benefit of T1-measurements in arrhythmic patients. | ||
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