Human mesenchymal stromal cells inhibit platelet activation and aggregation involving CD73-converted adenosine
Mesenchymal stromal cells (MSCs) are promising cell therapy candidates. Clinical application is considered safe. However, minor side effects have included thromboembolism and instant blood-mediated inflammatory reactions suggesting an effect of MSC infusion on hemostasis. Previous studies focusing o...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
4 July 2018
|
| In: |
Stem cell research & therapy
Year: 2018, Jahrgang: 9, Pages: 1-17 |
| ISSN: | 1757-6512 |
| DOI: | 10.1186/s13287-018-0936-8 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s13287-018-0936-8 Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13287-018-0936-8 
|
| Verfasserangaben: | P. Netsch, S. Elvers-Hornung, S. Uhlig, H. Klüter, V. Huck, F. Kirschhöfer, G. Brenner-Weiß, K. Janetzko, H. Solz, P. Wuchter, P. Bugert and K. Bieback |
| Zusammenfassung: | Mesenchymal stromal cells (MSCs) are promising cell therapy candidates. Clinical application is considered safe. However, minor side effects have included thromboembolism and instant blood-mediated inflammatory reactions suggesting an effect of MSC infusion on hemostasis. Previous studies focusing on plasmatic coagulation as a secondary hemostasis step detected both procoagulatory and anticoagulatory activities of MSCs. We now focus on primary hemostasis and analyzed whether MSCs can promote or inhibit platelet activation. |
|---|---|
| Beschreibung: | Gesehen am 26.07.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1757-6512 |
| DOI: | 10.1186/s13287-018-0936-8 |